Acetoacetanilide is a compound that is primarily utilized in the pharmaceutical and chemical industries for its various applications. In everyday life, this compound likely does not have direct relevance to the general populace. However, its importance lies in its contributions to the development of pharmaceutical products and other chemical processes that ultimately impact society as a whole. Its role in these industries underscores the significance of chemical compounds in advancing scientific research, healthcare, and technology.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
Acetoacetanilide, also known as acetoacetanilide or N-(phenylacetyl)acetamide, has several commercial and industrial applications. It is commonly used as a precursor in the production of certain dyes and pigments due to its ability to form brightly colored compounds. Additionally, acetoacetanilide is utilized in the manufacturing of various pharmaceuticals and as a chemical intermediate in organic synthesis processes.
In the realm of drug and medication applications, acetoacetanilide is mainly known for its role as a precursor in the production of certain analgesic, anti-inflammatory, and antipyretic drugs. When properly synthesized and formulated, it can be used as an active ingredient in pharmaceutical products designed to alleviate pain, reduce inflammation, and lower fever in patients. Its chemical structure and properties make it a valuable component in the creation of such medications that aim to improve health and well-being.
⚗️ Chemical & Physical Properties
Acetoacetanilide is a white crystalline solid with a slight characteristic odor. It is typically found in the form of fine powder or granules. The odor of acetoacetanilide is often described as faint and not very distinct.
The molar mass of acetoacetanilide is approximately 177.19 g/mol, with a density of around 1.22 g/cm³. In comparison to common food items, acetoacetanilide has a higher molar mass and density. For example, the molar mass of sucrose is 342.30 g/mol and the density of olive oil is 0.92 g/cm³.
Acetoacetanilide has a melting point of approximately 178-181°C and a boiling point of around 385°C. In comparison to common food items, acetoacetanilide has significantly higher melting and boiling points. For example, butter melts at around 32-35°C and water boils at 100°C.
Acetoacetanilide is sparingly soluble in water but readily soluble in organic solvents. It has a low viscosity, making it easy to handle as a chemical compound. In comparison to common food items, acetoacetanilide has lower solubility in water and viscosity. For example, sugar is highly soluble in water and honey has a high viscosity.
🏭 Production & Procurement
Acetoacetanilide, also known as acetoacetanilide, is a compound often synthesized through the Claisen condensation reaction. In this process, ethyl acetoacetate is reacted with aniline in the presence of a base catalyst such as sodium ethoxide to yield Acetoacetanilide.
Acetoacetanilide can be procured from chemical suppliers specializing in organic compounds, or it can be synthesized in a laboratory setting. The compound is typically transported in sealed containers to prevent contamination and ensure its stability during transit.
Once Acetoacetanilide reaches its destination, it should be stored in a cool, dry place away from direct sunlight and moisture. Proper labeling and handling procedures should be followed to minimize the risk of exposure and ensure the compound’s integrity for subsequent use in various chemical reactions.
⚠️ Safety Considerations
Safety considerations for Acetoacetanilide include ensuring proper handling to avoid skin and eye contact, as well as inhalation of its dust or vapors. It is important to work with this compound in a well-ventilated area and wear appropriate personal protective equipment such as gloves and safety goggles. Acetoacetanilide should be stored in a cool, dry place away from incompatible materials to prevent the risk of fire or explosion.
Hazard statements for Acetoacetanilide include its potential to cause skin and eye irritation upon contact, as well as respiratory irritation if inhaled. This compound may also be harmful if swallowed or absorbed through the skin, and can cause allergic skin reactions in some individuals. Additionally, Acetoacetanilide is a combustible dust and poses a fire hazard if exposed to heat or flame.
Precautionary statements for Acetoacetanilide recommend avoiding breathing in dust or vapor, as well as avoiding contact with skin and eyes. It is important to wash hands thoroughly after handling this compound and to seek medical attention immediately if any adverse effects occur. Store Acetoacetanilide in a tightly sealed container away from heat and ignition sources, and ensure proper waste disposal according to local regulations.
🔬 Potential Research Directions
Potential research directions for Acetoacetanilide may include its application as a precursor in organic synthesis for the preparation of various compounds. Chemists may explore its reactivity with different reagents to synthesize novel derivatives with potential biological activities.
Additionally, researchers could investigate the potential medicinal properties of Acetoacetanilide and its derivatives. Studies may focus on its potential anti-inflammatory, analgesic, or antimicrobial activities, which could lead to the development of new pharmaceutical agents for various diseases.
Furthermore, Acetoacetanilide could be studied for its potential use in materials science. The compound’s unique properties may make it suitable for applications in areas such as dye chemistry, polymer synthesis, or as a potential component in the development of new materials with specific properties.
🧪 Related Compounds
One similar compound to Acetoacetanilide based upon molecular structure is Benzoylacetanilide. This compound contains a benzoyl group attached to an acetanilide moiety, similar to how Acetoacetanilide contains an acetoacetyl group attached to an acetanilide moiety. Benzoylacetanilide is often used in the synthesis of various organic compounds due to its reactivity and stability.
Another compound closely related to Acetoacetanilide is Phenylacetoacetamide. This molecule consists of a phenyl group attached to an acetoacetamide moiety, similar to how Acetoacetanilide contains an acetoacetyl group attached to an acetanilide moiety. Phenylacetoacetamide is commonly utilized in the pharmaceutical industry for the synthesis of various drugs and pharmaceutical intermediates due to its versatile functional groups.
One more compound with a comparable structure to Acetoacetanilide is Acetoacetamide. This compound features a simple acetoacetyl functional group without the additional aromatic ring of the acetanilide moiety. Despite this difference, Acetoacetamide shares similar chemical properties and reactivity with Acetoacetanilide, making it a valuable compound in organic synthesis reactions. Acetoacetamide is often used as a precursor in the synthesis of various heterocyclic compounds and pharmaceutical agents.
