2,4-Dihydroxypyrimidine-5-carboxylic acid is a compound that plays a crucial role in various biological processes in living organisms. It is a building block for the synthesis of nucleic acids, which are essential for the growth and reproduction of cells. This compound is also utilized in the pharmaceutical industry for the development of drugs targeting diseases such as cancer and bacterial infections. In everyday life, the significance of 2,4-Dihydroxypyrimidine-5-carboxylic acid lies in its contribution to the advancement of medicine and the improvement of overall health and well-being.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
2,4-Dihydroxypyrimidine-5-carboxylic acid, also known as uracil-5-carboxylic acid, has several commercial and industrial applications. It is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and fluorescent dyes. Its ability to form various derivatives makes it a versatile compound in organic chemistry.
In the pharmaceutical industry, 2,4-Dihydroxypyrimidine-5-carboxylic acid is utilized in the synthesis of antiviral and anticancer drugs. It serves as a key intermediate in the production of medications used to treat HIV, herpes, and certain types of cancer. Its structural properties make it a valuable component in drug discovery and development.
Medicinally, 2,4-Dihydroxypyrimidine-5-carboxylic acid is also used as a precursor in the synthesis of nucleotide-based drugs, including acyclovir and lamivudine, which are commonly prescribed for viral infections. Its role as a building block in the pharmaceutical industry highlights its importance in drug formulation and design. Its wide range of applications underscores its significance in commercial, industrial, and medicinal sectors.
⚗️ Chemical & Physical Properties
2,4-Dihydroxypyrimidine-5-carboxylic acid is a white crystalline solid with no distinct odor. It is commonly found in the form of fine powder.
With a molar mass of 158.1 g/mol and a density of 1.88 g/cm³, 2,4-Dihydroxypyrimidine-5-carboxylic acid is heavier than most common food items such as sugar or flour. Its density is comparable to that of certain spices or salts.
2,4-Dihydroxypyrimidine-5-carboxylic acid has a melting point of 302-304°C and a boiling point of 487-488°C. These values are significantly higher than those of typical food items, which generally melt or boil at lower temperatures.
This compound is highly soluble in water and exhibits low viscosity. Its solubility and viscosity are quite different from those of most food items, which may have varying degrees of solubility and viscosity in aqueous solutions.
🏭 Production & Procurement
2,4-Dihydroxypyrimidine-5-carboxylic acid is typically produced through chemical synthesis in a laboratory setting. This involves reacting appropriate precursors under controlled conditions to yield the desired compound. Various methods and reaction pathways may be employed, depending on the specific requirements of the production process.
Once synthesized, 2,4-Dihydroxypyrimidine-5-carboxylic acid can be procured from chemical suppliers or pharmaceutical companies that specialize in the production and distribution of fine chemicals. The compound is typically available in the form of a solid or powder, packaged in suitable containers for transportation and storage. Special care must be taken when handling and transporting this compound, as it may be sensitive to light, moisture, or other environmental factors.
Transportation of 2,4-Dihydroxypyrimidine-5-carboxylic acid is typically carried out using standard chemical shipping protocols, which ensure the safe delivery of the compound to its intended destination. This may involve using specialized containers, packaging materials, and labeling to comply with regulations governing the transportation of hazardous materials. It is essential to follow established safety guidelines and procedures to prevent accidents or contamination during transit.
⚠️ Safety Considerations
Safety considerations for 2,4-Dihydroxypyrimidine-5-carboxylic acid, a chemical compound used in various research and industrial applications, include the need for proper handling and storage procedures to prevent accidental exposure. It is essential to use appropriate personal protective equipment such as gloves, goggles, and lab coats when working with this compound to minimize the risk of skin contact, eye irritation, or inhalation of fumes. Additionally, 2,4-Dihydroxypyrimidine-5-carboxylic acid should be stored in a well-ventilated area away from heat sources and incompatible materials to avoid potential fire hazards or chemical reactions.
Hazard statements for 2,4-Dihydroxypyrimidine-5-carboxylic acid include “Causes severe skin burns and eye damage” due to its corrosive nature. Prolonged or repeated exposure to this compound may result in irritation of the respiratory tract or mucous membranes. Inhalation of dust or vapors, as well as ingestion or contact with skin or eyes, should be avoided to prevent potential health hazards.
Precautionary statements for 2,4-Dihydroxypyrimidine-5-carboxylic acid emphasize the importance of wearing protective gloves, clothing, and eye/face protection when handling this chemical. It is recommended to work in a well-ventilated area and avoid breathing dust, fume, gas, mist, vapors, or spray. In case of skin contact, immediate removal of contaminated clothing and rinsing the affected area with plenty of water is advised. If swallowed, the individual should rinse their mouth and seek medical advice immediately.
🔬 Potential Research Directions
One potential research direction for 2,4-Dihydroxypyrimidine-5-carboxylic acid is its role in various biological processes. Studies could investigate its interactions with enzymes and proteins, as well as its potential as a therapeutic agent in disease treatment.
Another area of interest could be the synthesis and modification of 2,4-Dihydroxypyrimidine-5-carboxylic acid derivatives. Researchers could explore different chemical reactions to create new compounds with enhanced properties, such as improved stability or increased bioavailability.
Furthermore, examining the pharmacokinetics and pharmacodynamics of 2,4-Dihydroxypyrimidine-5-carboxylic acid could provide valuable insights into its efficacy and potential side effects. This research could help optimize dosing regimens and guide the development of novel drug delivery systems for improved therapeutic outcomes.
🧪 Related Compounds
1. One similar compound to 2,4-Dihydroxypyrimidine-5-carboxylic acid is Uracil, which is a component of RNA. Uracil is a pyrimidine derivative that contains two keto groups in positions 2 and 4, similar to the hydroxyl groups in 2,4-Dihydroxypyrimidine-5-carboxylic acid. While Uracil lacks the carboxylic acid moiety found in 2,4-Dihydroxypyrimidine-5-carboxylic acid, the structural similarities between the two compounds are noteworthy.
2. Another compound structurally related to 2,4-Dihydroxypyrimidine-5-carboxylic acid is Thymine, one of the four nucleobases in DNA. Thymine contains a methyl group at the fifth position of the pyrimidine ring, differentiating it from 2,4-Dihydroxypyrimidine-5-carboxylic acid. Despite this difference, both compounds share the characteristic pyrimidine ring structure, highlighting their structural resemblance.
3. Cytosine is a nucleobase that bears similarity to 2,4-Dihydroxypyrimidine-5-carboxylic acid due to its pyrimidine ring structure. Cytosine contains an amine group at the fourth position of the pyrimidine ring instead of hydroxyl groups, distinguishing it from 2,4-Dihydroxypyrimidine-5-carboxylic acid. However, the presence of the pyrimidine ring in both compounds underscores their structural relationship.
