Salicyluric acid is a metabolite of aspirin that is excreted in the urine. It is relevant to everyday life as it serves as a marker for aspirin consumption and can be used to monitor adherence to medication regimens in individuals taking aspirin for various purposes, such as pain management or cardiovascular health. Additionally, the detection of salicyluric acid in urine can be indicative of aspirin toxicity in cases of overdose. Therefore, understanding the presence of salicyluric acid in the body has practical implications for healthcare providers and patients alike.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
Salicyluric acid, a metabolite of the widely known pain reliever aspirin, has a number of commercial and industrial applications. It is commonly used as a precursor for the synthesis of various pharmaceuticals and dyes. Salicyluric acid also finds use in the production of plastics and other organic compounds due to its chemical properties.
In the realm of drug and medication applications, salicyluric acid serves as a marker for assessing aspirin metabolism in the body. Its presence in urine can indicate the extent to which aspirin has been metabolized and processed by the liver. Additionally, salicyluric acid has potential applications in pharmacokinetic studies to better understand how aspirin is broken down and excreted in the body.
⚗️ Chemical & Physical Properties
Salicyluric acid is a white crystalline solid with no distinct odor. It is often found in the form of small, needle-like crystals.
With a molar mass of 182.2 g/mol and a density of 1.35 g/cm³, salicyluric acid is relatively light compared to common household items such as table salt (molar mass of 58.44 g/mol, density of 2.16 g/cm³).
Salicyluric acid has a melting point of 155-158°C and a boiling point of 322°C. Compared to common household items like sugar (melting point of 186°C, boiling point of 368°C), salicyluric acid has a lower melting point but a slightly higher boiling point.
Salicyluric acid is slightly soluble in water and has a low viscosity. Compared to common household items such as salt and sugar which are highly soluble and have low viscosity, salicyluric acid exhibits moderate solubility and viscosity in water.
🏭 Production & Procurement
Salicyluric acid, also known as 2,5-dihydroxybenzoic acid, is a metabolite of salicylic acid. It is produced in the body when salicylic acid is metabolized by conjugation with glycine. This reaction takes place in the liver and results in the formation of Salicyluric acid, which is then eliminated from the body through urine.
Salicyluric acid can be procured from various sources, including pharmaceutical companies that produce it as a byproduct of salicylic acid metabolism studies. It can also be obtained through chemical synthesis in laboratory settings. Once produced, Salicyluric acid can be transported in its solid form or as a solution in a solvent such as ethanol or water. Proper handling and storage are necessary to prevent degradation and ensure the purity of the compound during transportation.
The procurement and transportation of Salicyluric acid require adherence to safety regulations and guidelines to ensure the integrity of the compound and prevent any potential hazards. Proper labeling and documentation of the compound’s properties are essential for safe handling and transportation. Additionally, the use of appropriate protective equipment and packaging materials is crucial to minimize any risks associated with the transport of Salicyluric acid.
⚠️ Safety Considerations
Safety considerations for Salicyluric acid include ensuring proper handling to avoid skin and eye contact, as well as inhalation. It is advisable to wear appropriate personal protective equipment, such as gloves and safety glasses, when working with the substance. Care should be taken to prevent ingestion of Salicyluric acid, as it may cause irritation or harm if ingested.
Salicyluric acid is a metabolite of salicylic acid formed in the body through conjugation with glycine. It is excreted in urine, and its presence can be used as an indicator of salicylate ingestion. Salicyluric acid is not pharmacologically active and does not contribute to the therapeutic effects of salicylic acid. It is primarily a marker for the metabolism of salicylic acid in the body.
Hazard statements for Salicyluric acid include causing irritation to skin, eyes, and respiratory system upon contact or inhalation. Prolonged or repeated exposure may lead to more severe health effects. Ingestion of Salicyluric acid can also cause gastrointestinal irritation and discomfort. It is important to handle the substance with care and follow proper safety precautions to prevent exposure.
Precautionary statements for Salicyluric acid include avoiding contact with skin, eyes, and clothing. In case of contact, rinse with plenty of water and seek medical advice if irritation persists. It is important to work in a well-ventilated area when handling Salicyluric acid to prevent inhalation of fumes. Store the substance in a cool, dry place away from incompatible materials and sources of ignition. Remember to wash hands thoroughly after handling Salicyluric acid to prevent accidental ingestion.
🔬 Potential Research Directions
Salicyluric acid, a metabolite of salicylic acid formed in the human body, has been of interest in various research fields. One potential research direction is its role in the pharmacokinetics and pharmacodynamics of salicylic acid, particularly in relation to its anti-inflammatory and analgesic effects. Understanding the metabolism of salicyluric acid may provide insights into optimizing dosing regimens and drug interactions involving salicylates.
Furthermore, the potential bioactivity of salicyluric acid itself has also been a subject of exploration. Studying its effects on different biological pathways and its potential therapeutic applications could lead to the development of novel drug candidates or therapies. Investigating the cellular mechanisms of action of salicyluric acid may shed light on its biological effects and physiological relevance.
Moreover, the influence of genetic polymorphisms on the metabolism and disposition of salicyluric acid is an area that warrants further investigation. Identifying genetic variants that affect the formation or elimination of salicyluric acid could have implications for personalized medicine and drug safety. Studying the interindividual variability in salicyluric acid metabolism may also contribute to a better understanding of individual responses to salicylates and related compounds.
🧪 Related Compounds
One similar compound to Salicyluric acid based upon molecular structure is Salicylic acid. Salicylic acid is a monohydroxybenzoic acid that differs from Salicyluric acid by the absence of a uric acid group. It is commonly used in the treatment of acne and various skin conditions due to its keratolytic properties.
Another compound similar to Salicyluric acid is 3-Hydroxybenzoic acid, also known as m-Hydroxybenzoic acid. This compound has a similar molecular structure to Salicyluric acid, with a hydroxyl group located on the meta position of the benzene ring. 3-Hydroxybenzoic acid is used in the synthesis of various pharmaceuticals and dyes.
Additionally, a compound with a molecular structure similar to Salicyluric acid is 2-Hydroxybenzoic acid, also known as o-Hydroxybenzoic acid. This compound differs from Salicyluric acid by the presence of a hydroxyl group on the ortho position of the benzene ring. 2-Hydroxybenzoic acid is commonly used in the production of food preservatives and antiseptics.
