(R)-Piperidine-2-carboxylic acid is a chemical compound that has a variety of applications in pharmaceuticals, agriculture, and materials science. It is used in the synthesis of drugs, such as antiviral and antibacterial agents, as well as in the production of agrochemicals to protect crops from pests and disease. Additionally, (R)-Piperidine-2-carboxylic acid is utilized in the creation of polymers and plastics, contributing to advancements in various industries. This compound plays a crucial role in the development of products that impact our daily lives, from medicines to food production to materials used in everyday objects.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
(R)-Piperidine-2-carboxylic acid, known as L-pipecolic acid, finds commercial and industrial applications as a key intermediate in the synthesis of pharmaceuticals, agrochemicals, and fine chemicals. Its chiral structure allows for its utilization in the production of various drugs, particularly those targeting central nervous system disorders and immunomodulation.
In the realm of drug development and medication, (R)-Piperidine-2-carboxylic acid serves as a critical building block for the manufacture of drugs such as pimozide, an antipsychotic agent, and gabapentin, a medication used to treat epilepsy and neuropathic pain. Moreover, its derivative, N-acylpipecolic acids, have shown significant anti-inflammatory and immune-modulating properties, making them valuable in the pharmaceutical industry for the treatment of autoimmune diseases and inflammatory conditions.
⚗️ Chemical & Physical Properties
(R)-Piperidine-2-carboxylic acid is a white crystalline solid with no distinct odor at room temperature. Its appearance is similar to other organic compounds commonly found in laboratories.
The molar mass of (R)-Piperidine-2-carboxylic acid is approximately 141.17 g/mol, with a density of about 1.094 g/cm³. Compared to common food items like sugar (180.16 g/mol) and salt (58.44 g/mol), (R)-Piperidine-2-carboxylic acid has a lower molar mass and higher density.
The melting point of (R)-Piperidine-2-carboxylic acid is around 248-250°C, while its boiling point is approximately 285-287°C. These values are significantly higher than those of common food items like butter (melting point: 32-35°C) and water (boiling point: 100°C).
(R)-Piperidine-2-carboxylic acid is sparingly soluble in water and has a low viscosity. This contrasts with common food items like sugar and salt, which are highly soluble in water and have a higher viscosity.
🏭 Production & Procurement
(R)-Piperidine-2-carboxylic acid is typically produced through chemical synthesis methods in laboratory settings. This involves the reaction of piperidine with a suitable carboxylic acid derivative, under controlled conditions, to yield the desired product.
In order to procure (R)-Piperidine-2-carboxylic acid, one may contact specialized chemical suppliers or manufacturers who produce and sell this compound. It is important to ensure that the compound meets the required purity standards for the intended application before making a purchase.
Once procured, (R)-Piperidine-2-carboxylic acid can be transported in sealed containers to prevent contamination or degradation. It is essential to follow proper handling and storage procedures to maintain the quality and integrity of the compound during transportation.
⚠️ Safety Considerations
Safety considerations for (R)-Piperidine-2-carboxylic acid include identifying and understanding the potential hazards associated with handling this compound. It is important to wear appropriate personal protective equipment such as gloves, goggles, and a lab coat when working with (R)-Piperidine-2-carboxylic acid to prevent skin contact, eye irritation, or inhalation of the substance. Proper ventilation is also crucial to minimize exposure and prevent any adverse health effects.
Hazard statements for (R)-Piperidine-2-carboxylic acid may include “Causes skin irritation,” “Causes serious eye irritation,” and “Harmful if swallowed.” These statements indicate the potential risks associated with exposure to the compound and emphasize the importance of taking necessary precautions to prevent any harm. It is essential to handle this substance with care and follow safety protocols to avoid any accidents or injuries.
Precautionary statements for (R)-Piperidine-2-carboxylic acid may include “Wear protective gloves/eye protection/face protection,” “IF ON SKIN: Wash with plenty of water,” and “IF IN EYES: Rinse cautiously with water for several minutes.” These statements provide specific instructions on how to handle the compound safely and efficiently in case of accidental exposure. Following these precautionary measures is crucial to ensure the well-being of individuals working with (R)-Piperidine-2-carboxylic acid and to prevent any potential health risks.
🔬 Potential Research Directions
One potential research direction for (R)-Piperidine-2-carboxylic acid is the investigation of its pharmacological properties. Researchers could explore its potential as a therapeutic agent for various conditions, such as neurological disorders or infectious diseases.
Another potential avenue of research could involve the synthesis of novel derivatives of (R)-Piperidine-2-carboxylic acid to enhance its biological activity or improve its pharmacokinetic properties. By modifying the chemical structure of the compound, researchers may discover new compounds with improved efficacy or reduced side effects.
Furthermore, studies could be conducted to elucidate the mechanisms of action of (R)-Piperidine-2-carboxylic acid at the molecular level. By understanding how the compound interacts with its molecular targets, researchers can gain insights into its biological effects and potentially identify new drug targets for therapeutic intervention.
🧪 Related Compounds
One compound that is structurally similar to (R)-Piperidine-2-carboxylic acid is (S)-Piperidine-2-carboxylic acid. This compound also contains a piperidine ring with a carboxylic acid group attached at the 2-position, but with the stereochemistry reversed compared to (R)-Piperidine-2-carboxylic acid. This subtle difference in stereochemistry can have important implications for biological activity and chemical reactivity.
Another compound with a similar molecular structure to (R)-Piperidine-2-carboxylic acid is 2,6-Dibromopiperidine-2-carboxylic acid. This compound retains the piperidine ring and carboxylic acid group at the 2-position, but with the addition of two bromine atoms at the 2 and 6 positions of the piperidine ring. The presence of bromine atoms can alter the physical and chemical properties of the molecule, making it useful for specific applications in organic synthesis and medicinal chemistry.
One more compound that shares structural similarities with (R)-Piperidine-2-carboxylic acid is Piperidine-4-carboxylic acid. In this compound, the carboxylic acid group is attached to the piperidine ring at the 4-position, rather than the 2-position as in (R)-Piperidine-2-carboxylic acid. This difference in substitution pattern can lead to differences in biological activity and pharmacological behavior, highlighting the importance of subtle structural variations in organic molecules.
