(R)-(-)-1-Amino-2-propanol, commonly known as R-AMIP, is a chemical compound that plays a significant role in various industries and applications. This compound is utilized in the production of pharmaceuticals, agrochemicals, and cosmetics, among other products. Specifically, R-AMIP is considered a key building block in the synthesis of numerous medications, as well as in the formulation of pesticides and personal care items. Given its versatility and importance in these sectors, R-AMIP is an essential component that impacts everyday life through the products that we use and rely on regularly.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
(R)-(-)-1-Amino-2-propanol, commonly known as DHPA, finds several commercial and industrial applications. It is used as a chiral building block in the synthesis of pharmaceuticals, agrochemicals, and fine chemicals due to its optical purity. Additionally, DHPA is utilized as a resolving agent in the separation of enantiomers and as a ligand in catalytic processes.
In drug and medication applications, (R)-(-)-1-Amino-2-propanol plays a significant role as a key intermediate in the synthesis of various active pharmaceutical ingredients (APIs). It is often employed in the production of beta-blockers, anti-depressants, and anti-inflammatory drugs. The chiral nature of DHPA makes it particularly valuable in the pharmaceutical industry for the development of enantiomerically pure compounds.
The unique properties of (R)-(-)-1-Amino-2-propanol make it a versatile compound with diverse applications. In addition to its role in pharmaceuticals, DHPA is utilized in the manufacture of herbicides, pesticides, and other agrochemicals. Its ability to act as a resolving agent also makes it essential in the production of optically pure compounds used in various industries.
⚗️ Chemical & Physical Properties
(R)-(-)-1-Amino-2-propanol is a colorless liquid with a slight ammonia-like odor. It is commonly used in the synthesis of pharmaceuticals and organic compounds due to its chiral properties.
The molar mass of (R)-(-)-1-Amino-2-propanol is approximately 89.14 g/mol, and its density is about 0.92 g/cm³. This places it within the range of molar mass and density of common food items such as sugar, salt, and baking soda.
The melting point of (R)-(-)-1-Amino-2-propanol is around -9.9°C, while its boiling point is about 138°C. Compared to common food items like butter, chocolate, and honey, its melting point is lower and its boiling point is higher.
(R)-(-)-1-Amino-2-propanol is soluble in water and has a relatively low viscosity. When compared to common food items like vinegar, soy sauce, and honey, it exhibits similar solubility in water but lower viscosity.
🏭 Production & Procurement
(R)-(-)-1-Amino-2-propanol, a compound of interest in the chemical industry, is primarily produced through the reductive amination of acetone with ammonia in the presence of a reducing agent such as sodium borohydride. This process yields the desired product with high enantiomeric purity, making it suitable for various applications in pharmaceuticals and organic synthesis.
Procurement of (R)-(-)-1-Amino-2-propanol involves sourcing raw materials such as acetone, ammonia, and a reducing agent from reputable suppliers. These chemicals are then used in a controlled synthesis process to produce the final product. Once synthesized, the compound can be transported in suitable containers to customers or further processing facilities.
Transportation of (R)-(-)-1-Amino-2-propanol is typically done in sealed containers to prevent contamination or evaporation of the compound. Special care must be taken to ensure the stability of the product during transit, as any degradation could impact its quality and usefulness in subsequent applications. Proper labeling and documentation are essential to comply with regulatory requirements and ensure safe handling throughout the supply chain.
⚠️ Safety Considerations
Safety considerations for (R)-(-)-1-Amino-2-propanol should be carefully observed due to its potential hazards. This compound may cause skin and eye irritation upon contact. Inhaling its vapors can lead to respiratory irritation as well. Therefore, proper protective equipment such as gloves, safety goggles, and respiratory protection should be worn when handling this substance to prevent any adverse effects.
In addition to skin and eye irritation, (R)-(-)-1-Amino-2-propanol poses a potential risk of causing serious health hazards. Prolonged or repeated exposure to this compound may result in respiratory sensitization. It may also be harmful if swallowed or inhaled. Therefore, strict adherence to safety protocols and guidelines is essential to minimize the risk of exposure and ensure a safe working environment.
When working with (R)-(-)-1-Amino-2-propanol, it is important to keep in mind the flammability hazards it presents. This compound is flammable and may ignite at high temperatures. Proper storage and handling procedures should be followed to prevent any potential fire hazards. It is also important to keep this substance away from sources of ignition and provide adequate ventilation to reduce the risk of fire or explosion.
The hazard statements for (R)-(-)-1-Amino-2-propanol include “Causes skin and eye irritation,” “May cause respiratory irritation,” and “May cause respiratory sensitization.” These statements highlight the potential risks associated with this compound and emphasize the importance of taking necessary precautions when working with it. It is crucial to handle (R)-(-)-1-Amino-2-propanol with care to avoid any adverse effects on health and safety.
Precautionary statements for (R)-(-)-1-Amino-2-propanol include “Avoid breathing vapors, mist, or gas,” “Wear protective gloves/eye protection/face protection,” and “Use only outdoors or in a well-ventilated area.” These statements provide guidelines on how to safely handle this compound and minimize the risk of exposure. By following these precautionary measures, individuals can reduce the likelihood of experiencing any harmful effects associated with (R)-(-)-1-Amino-2-propanol and ensure a safer working environment.
🔬 Potential Research Directions
Potential research directions for (R)-(-)-1-Amino-2-propanol, a chiral amine compound, may include investigating its applications in asymmetric synthesis as a chiral building block for pharmaceuticals and fine chemicals.
Further studies could explore the enantioselective catalytic reactions involving (R)-(-)-1-Amino-2-propanol, which can potentially lead to the development of new methodologies for the synthesis of enantiopure compounds with high optical purity.
Additionally, research efforts may focus on the development of new synthetic strategies for the preparation of (R)-(-)-1-Amino-2-propanol, including exploring novel synthetic routes and optimizing existing synthetic methodologies to improve efficiency and yield.
🧪 Related Compounds
One similar compound to (R)-(-)-1-Amino-2-propanol based upon molecular structure is (S)-(+)-1-Amino-2-propanol. This compound has the same molecular formula and similar chemical structure to (R)-(-)-1-Amino-2-propanol, but it differs in the stereochemistry at the chiral center. While (R)-(-)-1-Amino-2-propanol has an R configuration at the chiral center, (S)-(+)-1-Amino-2-propanol has an S configuration.
Another similar compound to (R)-(-)-1-Amino-2-propanol is 1-Amino-2-methylpropan-1-ol. This compound has the same molecular formula and similar chemical structure to (R)-(-)-1-Amino-2-propanol, but it differs in the position of the methyl group. Whereas (R)-(-)-1-Amino-2-propanol has a methyl group attached to the chiral center, 1-Amino-2-methylpropan-1-ol has a methyl group attached to the adjacent carbon atom.
A third similar compound to (R)-(-)-1-Amino-2-propanol is 2-Aminomethyl-1-propanol. This compound also shares the same molecular formula and similar chemical structure with (R)-(-)-1-Amino-2-propanol, but it differs in the position of the amino group. While (R)-(-)-1-Amino-2-propanol has the amino group attached to the chiral center, 2-Aminomethyl-1-propanol has the amino group attached to the carbon atom adjacent to the chiral center.
