Quinoline-4-carboxylic acid plays a crucial role in various industries and applications, including pharmaceuticals, agriculture, and material science. Its unique chemical structure allows it to be used as a key building block in the synthesis of new drugs, agrochemicals, and advanced materials. In the pharmaceutical sector, quinoline-4-carboxylic acid serves as a precursor for the production of antimalarial drugs like chloroquine and quinine. Additionally, it is utilized in the development of cancer treatments and other therapeutics. In agriculture, this compound is used to create pesticides and herbicides that help protect crops from pests and diseases. Furthermore, quinoline-4-carboxylic acid is employed in the production of dyes, pigments, and other specialty chemicals. Overall, the versatility and importance of this compound in various industries make it a significant component in our everyday lives.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
Quinoline-4-carboxylic acid is primarily utilized in various commercial and industrial applications. One of the key functions of this compound is its use as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Additionally, it is employed in the manufacturing of dyes, pigments, and other specialty chemicals.
In the realm of drug and medication applications, quinoline-4-carboxylic acid plays a crucial role as a building block in the synthesis of anti-malarial drugs such as chloroquine and amodiaquine. These medications are essential in the treatment and prevention of malaria, a disease caused by a parasite transmitted through the bite of infected mosquitoes. Quinoline-4-carboxylic acid’s pharmacological properties make it a valuable component in the pharmaceutical industry.
Furthermore, quinoline-4-carboxylic acid is also utilized in the development of drugs targeting tuberculosis, cancer, and other infectious diseases. Its versatile chemical structure allows for modifications that enhance the efficacy and specificity of the resulting pharmaceutical products. This compound’s significance in drug discovery and development underscores its importance in the medical field and underscores its diverse applications in improving human health.
⚗️ Chemical & Physical Properties
Quinoline-4-carboxylic acid is a white crystalline solid with a slight characteristic odor when pure. It has a faint, sweet odor that is not particularly strong or unpleasant.
With a molar mass of 173.15 g/mol and a density of 1.49 g/cm³, quinoline-4-carboxylic acid is similar in weight to common household items like vinegar (60.05 g/mol) but is denser than water (1 g/cm³).
Quinoline-4-carboxylic acid has a melting point of 265-270 °C and a boiling point of approximately 355 °C. Compared to common household items like sugar (melting point of 186 °C) and water (boiling point of 100 °C), it has a higher melting and boiling point.
This compound is sparingly soluble in water, with a solubility of approximately 0.155 g/L at 20°C. It has a relatively low viscosity compared to household items like honey but higher viscosity than water.
🏭 Production & Procurement
Quinoline-4-carboxylic acid is typically produced through the reaction of quinoline with carbon monoxide in the presence of a catalyst. This process, known as the Borch reaction, results in the formation of Quinoline-4-carboxylic acid as a white solid.
In order to procure Quinoline-4-carboxylic acid, one must first identify a reputable chemical supplier that carries the compound. Once the compound is obtained, it must be stored in a cool, dry place away from direct sunlight to prevent degradation. Quinoline-4-carboxylic acid can be transported in sealed containers to prevent spillage or contamination during transit.
The transportation of Quinoline-4-carboxylic acid should adhere to all local and international regulations regarding the handling and transportation of hazardous chemicals. Proper labeling and documentation are vital to ensure the safe and secure transport of Quinoline-4-carboxylic acid from the supplier to the end user. It is advisable to work with experienced professionals when dealing with the procurement and transportation of Quinoline-4-carboxylic acid to minimize risks and ensure compliance with all relevant regulations.
⚠️ Safety Considerations
Safety considerations for Quinoline-4-carboxylic acid include its potential to irritate the skin, eyes, and respiratory tract upon contact or inhalation. Proper personal protective equipment, such as gloves and safety glasses, should be worn when handling this compound. Additionally, Quinoline-4-carboxylic acid should be stored in a well-ventilated area away from incompatible substances to prevent accidental reactions or releases.
The pharmacology of Quinoline-4-carboxylic acid involves its role as a precursor in the synthesis of various pharmaceutical compounds. This organic building block is utilized in the production of antimalarial agents, antifungal medications, and anti-inflammatory drugs. Furthermore, Quinoline-4-carboxylic acid exhibits moderate antimicrobial activity against certain bacteria and fungi, making it a valuable component in the development of novel pharmaceuticals.
Hazard statements for Quinoline-4-carboxylic acid include its classification as a skin and eye irritant, as well as a respiratory sensitizer. Prolonged or repeated exposure to this compound may cause adverse health effects such as dermatitis, eye irritation, and respiratory discomfort. It is important to handle Quinoline-4-carboxylic acid with caution and follow proper safety protocols to minimize the risk of potential hazards.
Precautionary statements for Quinoline-4-carboxylic acid advise users to avoid direct skin contact and inhalation of vapors or dust. In case of contact with eyes or skin, it is recommended to rinse thoroughly with water and seek medical attention if irritation persists. Proper ventilation, containment measures, and personal protective equipment should be utilized to ensure the safe handling and storage of Quinoline-4-carboxylic acid.
🔬 Potential Research Directions
One potential research direction for Quinoline-4-carboxylic acid is its potential as a building block for the synthesis of bioactive compounds. The molecular structure of Quinoline-4-carboxylic acid lends itself to modifications that can lead to the creation of new pharmaceuticals or agrochemicals.
Another potential area of research is investigating the pharmacological properties of Quinoline-4-carboxylic acid and its derivatives. Studies could focus on its potential as an anti-inflammatory, anti-cancer, or antimicrobial agent. Understanding the biological activities of this compound can provide valuable insights for drug discovery efforts.
Furthermore, exploring the synthetic methodologies for Quinoline-4-carboxylic acid derivatives could also be an interesting research direction. Developing efficient and environmentally-friendly routes for the synthesis of these compounds can contribute to the scalability and accessibility of potential new drugs. Additionally, investigating the structural-activity relationship of Quinoline-4-carboxylic acid analogs could lead to the design of more potent and selective compounds for various therapeutic applications.
🧪 Related Compounds
One similar compound to Quinoline-4-carboxylic acid based on molecular structure is Quinoline-2-carboxylic acid. This compound also contains a quinoline ring system, but the carboxylic acid group is attached to the 2-position of the quinoline ring instead of the 4-position. This slight structural difference can result in different chemical properties and biological activities compared to Quinoline-4-carboxylic acid.
Another related compound is Quinoline-3-carboxylic acid, which features a carboxylic acid group attached to the 3-position of the quinoline ring. This subtle alteration in the position of the carboxylic acid functionality can impact the compound’s reactivity and interaction with other molecules. Understanding the similarities and differences between Quinoline-4-carboxylic acid and Quinoline-3-carboxylic acid can provide insights into their potential applications in various fields.
