Oxindole is a naturally occurring compound found in certain plants and animals that has gained attention for its potential health benefits. Studies have shown that Oxindole possesses anti-inflammatory and anti-cancer properties, making it a promising area of research in the field of medicine. Furthermore, Oxindole is being investigated for its potential to treat certain neurological disorders, such as Alzheimer’s disease and Parkinson’s disease. As research continues to uncover the potential therapeutic uses of Oxindole, it may become a valuable tool in improving human health and well-being.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
One commercial application of oxindole is as a building block in the synthesis of pharmaceuticals and agrochemicals. Its versatile structure makes it attractive for use in drug discovery and lead optimization in the pharmaceutical industry.
Industrially, oxindole is used as a precursor in the production of dyes and pigments. Its chemical properties allow for the creation of vibrant colors and stable formulations, making it a valuable component in various industrial processes.
In the realm of drug and medication applications, oxindole derivatives have shown promise as potential anticancer agents. Research has indicated their ability to inhibit tumor cell growth and induce cell death, making them valuable candidates for further development in cancer therapy.
⚗️ Chemical & Physical Properties
Oxindole is a white crystalline solid with a faint odor. It is often described as having a slightly bitter taste.
The molar mass of Oxindole is approximately 147.15 g/mol, and its density is around 1.34 g/cm³. In comparison, common food items such as sugar and salt have molar masses closer to 180 g/mol and densities around 2 g/cm³, respectively.
Oxindole has a melting point of about 102-104°C and a boiling point of approximately 290-295°C. This differs from common food items such as butter, which melts around 32-35°C, and water, which boils at 100°C.
Oxindole has limited solubility in water and is relatively viscous. In contrast, common food items like sugar are highly soluble in water, and oils are less viscous.
🏭 Production & Procurement
Oxindole is produced through various synthetic methods in the laboratory setting. One common method involves the condensation of aniline and ethyl glyoxalate followed by cyclization to form the oxindole ring. Alternatively, the Fischer indole synthesis can also be employed to produce Oxindole from aniline and a suitable substituent.
Oxindole can be procured through various chemical suppliers who specialize in the distribution of fine chemicals. It is typically available in both bulk quantities for industrial use and smaller amounts for research purposes. Due to its stable nature, Oxindole can be transported via standard shipping methods without requiring special handling procedures.
In terms of transportation, Oxindole is typically shipped in sealed containers to prevent exposure to moisture and contaminants. It is important to store Oxindole in a cool, dry place away from direct sunlight to maintain its stability. Additionally, proper labeling and documentation are required when transporting Oxindole to ensure compliance with regulations governing the transport of hazardous materials.
⚠️ Safety Considerations
Safety considerations for Oxindole include handling the compound with appropriate personal protective equipment, such as gloves and safety glasses, to prevent skin and eye irritation. It is important to work with Oxindole in a well-ventilated area or use a fume hood to avoid inhaling the vapors. In case of accidental ingestion, seek immediate medical attention and do not induce vomiting.
Hazard statements for Oxindole include “May cause respiratory irritation” and “Causes skin irritation.” These statements indicate the potential risks associated with exposure to the compound, highlighting the need for proper precautionary measures when working with Oxindole. It is important to minimize direct contact with the skin and ensure adequate ventilation to reduce the risk of respiratory irritation.
Precautionary statements for Oxindole advise to wear protective gloves, eye protection, and face protection when handling the compound to prevent skin and eye irritation. Avoid breathing in vapors or dust, as it may cause respiratory irritation. In case of skin contact, wash with soap and water, and in case of eye contact, rinse cautiously with water for several minutes while removing contact lenses, if present.
🔬 Potential Research Directions
One potential research direction for oxindole is its role in anti-cancer therapy. Studies have shown that oxindole derivatives exhibit promising cytotoxic effects on various cancer cell lines, making them a potential candidate for the development of new cancer treatments.
Another promising area of research is the neuroprotective properties of oxindole. Oxindole derivatives have been found to possess antioxidant and anti-inflammatory properties, which may be beneficial in the treatment of neurodegenerative diseases such as Alzheimer’s and Parkinson’s.
Furthermore, the potential use of oxindole in the field of drug discovery is an interesting avenue for research. By exploring the diverse pharmacological activities of oxindole derivatives, scientists may uncover new drug candidates for a range of therapeutic applications, including cardiovascular diseases, infectious diseases, and autoimmune disorders.
🧪 Related Compounds
One similar compound to Oxindole based upon molecular structure is Indole-3-carbinol. This compound is a derivative of Indole and consists of a substituted indole ring with a carbinol functional group added. Indole-3-carbinol has been studied for its potential anti-cancer properties and is found in cruciferous vegetables such as broccoli and cabbage.
Another compound similar to Oxindole is Indoline. Indoline is a bicyclic compound with a five-membered ring containing a nitrogen atom. It is structurally related to Oxindole as both contain a carbonyl group adjacent to a nitrogen atom in a five-membered ring. Indoline is used in the synthesis of various pharmaceuticals and has been investigated for its potential biological activities.
One more compound with a molecular structure similar to Oxindole is Isatin. Isatin is a fused heterocyclic compound containing a benzene ring fused to a five-membered nitrogen-containing ring. Like Oxindole, Isatin contains a ketone group adjacent to a nitrogen atom in a five-membered ring. Isatin is a versatile precursor in the synthesis of various bioactive molecules and has shown promising pharmacological activities in research studies.
