Nordihydroguaiaretic acid, also known as NDGA, is a compound found in the resin of the creosote bush. While not commonly discussed in everyday conversations, NDGA has shown promising potential in various scientific studies for its antioxidant and anti-inflammatory properties. These properties make it potentially beneficial for various health conditions, including cancer, diabetes, cardiovascular disease, and age-related illnesses. As research in the field of biochemistry and pharmacology continues to progress, the relevance of NDGA to everyday life may become more apparent as new health products and treatments are developed utilizing its properties.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
Nordihydroguaiaretic acid, also known as NDGA, has various commercial and industrial applications. It is commonly used as an antioxidant in the food industry to prevent food spoilage and extend shelf life. NDGA is also utilized in the cosmetic industry for its preservative properties in skincare products.
In terms of drug and medication applications, Nordihydroguaiaretic acid has been studied for its potential therapeutic benefits. It has demonstrated anti-inflammatory and anti-cancer properties, making it a promising candidate for the development of new pharmaceutical drugs. Additionally, NDGA has shown potential in the treatment of respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD).
⚗️ Chemical & Physical Properties
Nordihydroguaiaretic acid, also known as NDGA, is a white crystalline solid with a faint odor. It is commonly referred to as a potent antioxidant due to its ability to scavenge free radicals.
The molar mass of NDGA is approximately 302.4 g/mol, with a density of around 1.1 g/cm³. This places it in the range of other organic compounds found in food items, such as vitamins and amino acids, in terms of molar mass and density.
NDGA has a melting point of about 140-142°C and a boiling point of approximately 270-275°C. These values are higher compared to many common food ingredients, such as sugars and fats, which typically have lower melting and boiling points.
Nordihydroguaiaretic acid is sparingly soluble in water but dissolves well in organic solvents. It has a relatively low viscosity, making it easy to handle in laboratory settings. In comparison to common food items, NDGA’s solubility in water is lower, and its viscosity may be slightly higher than that of some liquid food products.
🏭 Production & Procurement
Nordihydroguaiaretic acid, also known as NDGA, is typically produced through the extraction of creosote bush (Larrea tridentata) leaves. The leaves are harvested, dried, and processed to isolate the desired compound. This process involves several steps of extraction, purification, and crystallization to obtain pure Nordihydroguaiaretic acid.
Once produced, Nordihydroguaiaretic acid can be procured from specialized chemical suppliers or pharmaceutical companies. It is generally available in the form of a white crystalline powder. Transportation of Nordihydroguaiaretic acid typically occurs in sealed containers to prevent contamination or degradation of the compound. Due to its chemical nature, proper handling and storage are essential during transportation to maintain the integrity of the product.
Procurement of Nordihydroguaiaretic acid for research or industrial purposes may require adherence to specific regulations and guidelines governing the handling of hazardous chemicals. Suppliers and buyers must ensure compliance with safety protocols and environmental regulations to minimize risks associated with the production and transportation of Nordihydroguaiaretic acid. Additionally, proper documentation and labeling are essential to track the movement of the compound and ensure its safe handling throughout the procurement process.
⚠️ Safety Considerations
Safety considerations for Nordihydroguaiaretic acid (NDGA) should include proper handling, storage, and disposal procedures to avoid any potential health risks. NDGA should be kept in a tightly closed container in a cool, dry, well-ventilated area away from incompatible substances. Personal protective equipment such as gloves, goggles, and lab coat should be worn when handling NDGA to prevent contact with skin or eyes. In case of accidental exposure, immediate medical attention should be sought.
Hazard statements for Nordihydroguaiaretic acid include “Causes skin and eye irritation”, “May cause respiratory irritation”, and “Harmful if swallowed”. These statements highlight the potential risks associated with exposure to NDGA, emphasizing the importance of implementing proper safety measures when working with this compound. It is essential to follow stringent safety protocols to minimize the risk of harm to individuals handling NDGA.
Precautionary statements for Nordihydroguaiaretic acid recommend wearing protective gloves, eye protection, and face protection to prevent exposure. It is also advised to wash hands thoroughly after handling NDGA and to avoid breathing in dust, fume, gas, mist, vapors, or spray. In case of skin irritation or rash, medical advice should be sought, and contaminated clothing should be removed and washed before reuse. Proper ventilation should be ensured when working with NDGA to reduce the risk of inhaling harmful vapors.
🔬 Potential Research Directions
Research on Nordihydroguaiaretic acid (NDGA) includes exploring its potential therapeutic effects on various health conditions such as cancer, inflammation, and skin disorders. Studies have shown that NDGA exhibits antioxidant and anti-inflammatory properties, making it a promising candidate for further investigation in the field of medicine.
Furthermore, the potential antibacterial and antiviral properties of NDGA have also sparked interest among researchers. There is ongoing research to evaluate the effectiveness of NDGA in combating various bacterial and viral infections, which could lead to the development of novel antimicrobial agents in the future.
Additionally, the neuroprotective effects of NDGA have been a subject of interest in recent research. Studies have suggested that NDGA may have a protective role in neurodegenerative diseases by reducing oxidative stress and inflammation in the brain. Further exploration into this area may provide valuable insights into the potential therapeutic applications of NDGA in treating neurological disorders.
🧪 Related Compounds
One similar compound to Nordihydroguaiaretic acid based upon molecular structure is Pyrocatechol, also known as catechol. Pyrocatechol has a similar phenolic structure to Nordihydroguaiaretic acid, with two hydroxyl groups attached to a benzene ring. Pyrocatechol is commonly used in the production of pharmaceuticals, dyes, and as a photographic developer due to its antioxidant properties.
Another compound with a molecular structure similar to Nordihydroguaiaretic acid is Resorcinol. Resorcinol, also known as m-dihydroxybenzene, contains two hydroxyl groups attached to a benzene ring, similar to the structure of Nordihydroguaiaretic acid. Resorcinol is used in skincare products, hair dyes, and as a chemical intermediate in the synthesis of pharmaceuticals.
Hydroquinone is another compound that shares a similar molecular structure to Nordihydroguaiaretic acid. Hydroquinone, also known as p-dihydroxybenzene, contains two hydroxyl groups attached to a benzene ring, similar to Nordihydroguaiaretic acid. Hydroquinone is commonly used as a skin-lightening agent in cosmetics and pharmaceuticals due to its ability to inhibit melanin production.