N,N-Dimethylbenzamide, a chemical compound with numerous industrial applications, plays a crucial role in various sectors of everyday life. This compound is commonly utilized as an intermediate in the production of pharmaceuticals, fragrance ingredients, and plastics. Its properties make it an essential ingredient in the synthesis of a wide range of products that we encounter in our daily lives, contributing significantly to the development of various consumer goods and essential materials.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
N,N-Dimethylbenzamide, also known as DMB, is widely used in various commercial and industrial applications. It is commonly utilized as a solvent in the production of polymers, resins, and coatings. Its high solvency power and stability make it a valuable ingredient in the manufacturing of adhesives, dyes, and insecticides.
Furthermore, N,N-Dimethylbenzamide is often employed as a corrosion inhibitor in metalworking fluids and lubricants. Its ability to protect metals from degradation and extend the lifespan of industrial equipment makes it a popular choice in the manufacturing and automotive industries. Additionally, it is utilized in the synthesis of pharmaceuticals and agricultural chemicals due to its versatile chemical properties.
In the realm of drug and medication applications, N,N-Dimethylbenzamide is primarily used as a topical analgesic in pain relief creams and ointments. Its numbing effects on the skin make it an effective ingredient in over-the-counter products designed to alleviate minor aches and pains. Additionally, it is occasionally included in skincare formulations for its soothing and cooling properties.
⚗️ Chemical & Physical Properties
N,N-Dimethylbenzamide is a colorless to pale yellow liquid with a faint odor. It is commonly used as a reagent in organic synthesis and as a solvent in various chemical reactions. The odor of N,N-Dimethylbenzamide is not easily detectable at low concentrations, making it relatively odorless compared to other organic compounds.
With a molar mass of 135.18 g/mol and a density of 1.01 g/cm³, N,N-Dimethylbenzamide is heavier than common food items such as water (molar mass of 18.02 g/mol, density of 1 g/cm³) and sugar (molar mass of 342.30 g/mol, density of 1.59 g/cm³). This indicates that N,N-Dimethylbenzamide is more dense and has a higher molecular weight compared to these common food items, making it a relatively heavy organic compound.
N,N-Dimethylbenzamide has a melting point of 10-12°C and a boiling point of 194-195°C. In comparison, water has a melting point of 0°C and a boiling point of 100°C, while sugar has a melting point of 186°C and does not have a specific boiling point. This shows that N,N-Dimethylbenzamide has a relatively low melting point compared to sugar but a higher boiling point than both water and sugar.
N,N-Dimethylbenzamide is sparingly soluble in water, forming a clear solution at low concentrations. It has a viscosity higher than water but lower than sugar solutions, indicating that it has moderate flow characteristics. This solubility and viscosity profile makes N,N-Dimethylbenzamide different from common food items, which are typically more soluble and less viscous in water.
🏭 Production & Procurement
N,N-Dimethylbenzamide is typically produced through a reaction between dimethylamine and benzoyl chloride in the presence of a base such as triethylamine. This process results in the formation of the desired product, N,N-Dimethylbenzamide, which can be isolated and purified through standard laboratory techniques.
Once produced, N,N-Dimethylbenzamide can be procured from chemical suppliers or manufacturers specializing in fine chemicals. The compound is commonly available for purchase in various quantities, ranging from small quantities for research purposes to bulk quantities for industrial applications. N,N-Dimethylbenzamide can be transported in sealed containers and stored in a cool, dry place to maintain its stability and quality.
Alternatively, N,N-Dimethylbenzamide can also be synthesized in-house by laboratories equipped with the necessary chemical reagents and equipment. This allows for greater control over the production process and ensures a reliable supply of the compound for ongoing research or industrial activities. Diligent handling and adherence to safety protocols are essential when working with N,N-Dimethylbenzamide to prevent any potential hazards or accidents.
⚠️ Safety Considerations
Safety considerations for N,N-Dimethylbenzamide include its potential as a skin and eye irritant, as well as its harmful effects if ingested or inhaled. It is important to handle this substance with caution and use appropriate personal protective equipment such as gloves, goggles, and a lab coat. Additionally, N,N-Dimethylbenzamide should be stored in a well-ventilated area away from heat sources and incompatible materials to prevent accidents or chemical reactions.
Hazard statements for N,N-Dimethylbenzamide include “Causes skin irritation,” “Causes serious eye irritation,” and “Harmful if swallowed.” These statements indicate the potential dangers associated with this substance and emphasize the importance of handling it with care to minimize the risk of adverse health effects. Individuals working with N,N-Dimethylbenzamide should be aware of these hazards and take appropriate safety precautions to protect themselves and others.
Precautionary statements for N,N-Dimethylbenzamide include “Wash hands thoroughly after handling,” “Wear protective gloves/eye protection/face protection,” and “IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.” These statements outline specific actions that should be taken to minimize the risks associated with this substance and provide guidelines for responding to potential exposure incidents. By following these precautionary measures, individuals can reduce the likelihood of accidents and ensure their safety when working with N,N-Dimethylbenzamide.
🔬 Potential Research Directions
Research on N,N-Dimethylbenzamide has shown its potential as a versatile building block in organic synthesis. Its unique structure and reactivity make it an interesting target for investigating new synthetic methodologies and developing innovative chemical transformations.
One exciting research direction for N,N-Dimethylbenzamide is the development of novel catalytic methods for its functionalization. By exploring new catalytic systems and reaction conditions, researchers can unlock the full potential of this compound for the synthesis of complex molecules with diverse applications in pharmaceuticals, materials science, and other fields.
Another promising area of research is the study of the biological activities of N,N-Dimethylbenzamide and its derivatives. Understanding the interaction of these compounds with biological systems could lead to the development of new drugs with enhanced efficacy and reduced side effects. Additionally, exploring the potential for N,N-Dimethylbenzamide as a prodrug or targeting moiety in drug delivery systems could open up new possibilities for improving drug delivery and therapeutic outcomes.
🧪 Related Compounds
One similar compound to N,N-Dimethylbenzamide is N,N-Diethylbenzamide, which features two ethyl groups attached to the nitrogen atom of the benzamide core. This compound shares a similar structure to N,N-Dimethylbenzamide but differs in the substitution of methyl groups for ethyl groups. N,N-Diethylbenzamide is commonly used as an insect repellent due to its strong odor and potential toxicity to pests.
Another related compound is N,N-Dipropylbenzamide, which contains two propyl groups attached to the nitrogen atom of the benzamide core. This compound is structurally similar to N,N-Dimethylbenzamide but features longer alkyl chains. N,N-Dipropylbenzamide is utilized in various industries as a fragrance ingredient, as the propyl groups contribute to its distinct scent profile and volatility.
N,N-Diisopropylbenzamide is yet another analogous compound to N,N-Dimethylbenzamide, with two isopropyl groups attached to the nitrogen atom of the benzamide core. This compound shares a comparable structure with N,N-Dimethylbenzamide but exhibits different chemical properties due to the presence of bulkier isopropyl groups. N,N-Diisopropylbenzamide is commonly employed in the formulation of personal care products and perfumes for its unique odor characteristics and solubility in various solvents.
