N-tert-Butylacetamide is a chemical compound commonly used in the pharmaceutical industry as a solvent for various drugs and compounds. Its relevance to everyday life lies in its role in the development of medications and pharmaceutical products that affect millions of people worldwide. By serving as a key component in the formulation process, N-tert-Butylacetamide plays a crucial role in the creation of medications that improve health and well-being, demonstrating its significance in our daily lives.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
N-tert-Butylacetamide, also known as N-t-Butylacetamide or NBAM, finds various commercial and industrial applications due to its unique properties. It is commonly used as a solvent in the production of pharmaceuticals, pesticides, and other chemicals. In addition, NBAM is utilized in the manufacturing of lubricants, plastics, and coatings due to its high solvency power and stability.
In the pharmaceutical industry, N-tert-Butylacetamide plays a significant role in drug development and formulation. It is commonly used as a solvent for poorly soluble drugs, aiding in their solubilization and enhancing their bioavailability. Furthermore, NBAM is utilized in the formulation of topical medications, such as creams and ointments, due to its emollient properties and compatibility with various active ingredients. Its low toxicity and favorable skin permeation properties make it a preferred choice for pharmaceutical applications.
⚗️ Chemical & Physical Properties
N-tert-Butylacetamide is a colorless liquid with a faint odor. It is soluble in organic solvents and exhibits a low volatility.
The molar mass of N-tert-Butylacetamide is approximately 131.21 g/mol and its density is around 0.973 g/mL. These properties make it similar in molar mass to common food items such as sucrose (table sugar) while having a lower density compared to most food items.
N-tert-Butylacetamide has a melting point of -11 to -9°C and a boiling point of 203 to 206°C. These values are higher compared to many common food items.
N-tert-Butylacetamide is sparingly soluble in water and has low viscosity. This contrasts with many common food items which are more soluble in water and often exhibit higher viscosity levels.
🏭 Production & Procurement
N-tert-Butylacetamide, a chemical compound utilized in various industries, is typically produced through a multistep synthesis process. The primary starting materials for its production are tert-butanol and acetic anhydride, which undergo a reaction to yield N-tert-Butylacetamide under specific conditions. This process may involve additional steps, such as purification and isolation, to obtain the final product in high purity.
The procurement of N-tert-Butylacetamide involves sourcing the necessary starting materials, which can be acquired from chemical suppliers or manufacturers. Once the compound is synthesized, it may be packaged and stored in suitable containers for transportation. Depending on the quantity required, N-tert-Butylacetamide can be shipped via various methods, including air, sea, or land freight, in compliance with regulations governing the transport of hazardous chemicals.
In the transportation of N-tert-Butylacetamide, proper handling and storage practices are essential to ensure its integrity and safety during transit. It is crucial to adhere to guidelines for the handling of hazardous chemicals, including the use of appropriate packaging, labeling, and documentation. Additionally, precautions should be taken to prevent exposure to moisture or extreme temperatures, which could compromise the quality of the compound.
⚠️ Safety Considerations
Safety considerations for N-tert-Butylacetamide are important to understand in order to handle the substance safely. It is essential to use appropriate personal protective equipment when working with N-tert-Butylacetamide, such as gloves, goggles, and a lab coat, to prevent skin contact and inhalation of the substance. In addition, N-tert-Butylacetamide should be stored in a well-ventilated area away from heat sources and incompatible materials to prevent accidents and chemical reactions.
Hazard statements for N-tert-Butylacetamide include phrases such as “Causes skin irritation,” “Causes serious eye irritation,” and “Harmful if swallowed.” These statements indicate the potential dangers of exposure to N-tert-Butylacetamide and highlight the importance of following proper safety protocols when working with the substance to avoid adverse health effects. It is crucial to be aware of these hazards and take necessary precautions to minimize the risks associated with N-tert-Butylacetamide.
Precautionary statements for N-tert-Butylacetamide advise individuals to wear protective gloves, eye protection, and face protection when handling the substance to prevent skin and eye irritation. It is also recommended to avoid breathing in vapors or mists of N-tert-Butylacetamide and to work in a well-ventilated area to reduce exposure levels. In case of ingestion, individuals should seek medical advice immediately and show the product label or Safety Data Sheet to healthcare professionals for proper treatment. These precautionary measures are crucial in ensuring the safe handling of N-tert-Butylacetamide and protecting individuals from potential harm.
🔬 Potential Research Directions
Research on N-tert-Butylacetamide, a derivative of acetamide, shows potential for further exploration in the field of organic chemistry. Its structural properties and potential reactivity with various functional groups make it a valuable intermediate in the synthesis of complex organic molecules.
The investigation of N-tert-Butylacetamide’s compatibility with various reaction conditions and catalysts could lead to the development of more efficient synthetic routes for the production of pharmaceuticals, agrochemicals, and advanced materials. Moreover, studies on its stereochemistry and chiral resolution may offer insights into asymmetric synthesis strategies.
Exploring the biological activity of N-tert-Butylacetamide and its derivatives could uncover new applications in the pharmaceutical industry. Additionally, understanding its pharmacokinetics and metabolism could provide valuable information for drug development and lead optimization efforts.
🧪 Related Compounds
One similar compound to N-tert-Butylacetamide is N,N-Dimethylacetamide. This compound has a similar molecular structure, with a carbonyl group attached to an amide nitrogen atom. The difference lies in the substituents on the nitrogen atom, with N,N-Dimethylacetamide having two methyl groups instead of a tert-Butyl group.
Another compound with a structure similar to N-tert-Butylacetamide is N-Ethylacetamide. In this compound, the nitrogen atom is attached to an ethyl group instead of a tert-Butyl group. Despite this difference in substituents, N-Ethylacetamide retains the basic structure of an amide compound.
A third similar compound is N-Isobutylacetamide. In this compound, the nitrogen atom is attached to an isobutyl group rather than a tert-Butyl group. This small difference in substituents results in slightly different physical and chemical properties compared to N-tert-Butylacetamide.
