N-Methyl-p-toluenesulfonamide is a chemical compound commonly used as a plasticizer in various consumer products such as nail polish, adhesives, and coatings. Its relevance to everyday life lies in its ability to impart flexibility and durability to these products, thus enhancing their performance and longevity. Additionally, N-Methyl-p-toluenesulfonamide is also utilized in pharmaceuticals and as a corrosion inhibitor in industrial applications, further highlighting its importance in modern society.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
N-Methyl-p-toluenesulfonamide, commonly known as Toluenesulfonamide, is widely used in various commercial and industrial applications. It is commonly found in the production of polyurethane adhesives, coatings, and sealants due to its excellent adhesion properties. Additionally, it is used as a plasticizer in PVC formulations to enhance flexibility and durability.
In the pharmaceutical industry, N-Methyl-p-toluenesulfonamide is utilized as a key ingredient in the production of certain medications. It is often used as a component in topical ointments and creams due to its ability to enhance skin penetration and improve drug delivery. Furthermore, it is used as a solubilizing agent in liquid pharmaceutical formulations to increase drug solubility and bioavailability.
The versatile properties of N-Methyl-p-toluenesulfonamide make it a valuable compound in a wide range of applications. Its commercial and industrial uses include being a key additive in plastic manufacturing, adhesives, and sealants. In the pharmaceutical realm, it is utilized for enhancing drug delivery and solubility in various medications and topical formulations.
⚗️ Chemical & Physical Properties
N-Methyl-p-toluenesulfonamide is a white crystalline solid with a slight odor. It is commonly used as a plasticizer in various industries.
The molar mass of N-Methyl-p-toluenesulfonamide is 213.28 g/mol, and its density is 1.24 g/cm3. In comparison, common food items such as sugar and salt have molar masses ranging from 58.44 g/mol to 58.44 g/mol, and densities ranging from 1.59 g/cm3 to 2.16 g/cm3.
The melting point of N-Methyl-p-toluenesulfonamide is 102-103°C, and the boiling point is 102-104°C. In contrast, common food items such as butter have melting points ranging from 30-35°C, while water has a boiling point of 100°C.
N-Methyl-p-toluenesulfonamide is sparingly soluble in water and exhibits low viscosity. This differs from common food items like sugar and salt, which are highly soluble in water and have higher viscosities.
🏭 Production & Procurement
N-Methyl-p-toluenesulfonamide, commonly used as a chemical intermediate in various industries, is produced through a multistep synthesis process. Initially, toluene is reacted with methylamine to form N-Methyl-p-toluenesulfonamide as an intermediate, which is subsequently converted into the final product through additional chemical reactions.
The procurement of N-Methyl-p-toluenesulfonamide typically involves purchasing the compound from chemical suppliers that specialize in providing fine chemicals. It is commonly available in both liquid and solid forms, depending on the specific requirements of the end-user. Once procured, the compound can be transported in sealed containers or drums to ensure safe handling and storage.
Transportation of N-Methyl-p-toluenesulfonamide is typically carried out using standard chemical shipping protocols to minimize any potential risks of exposure or contamination. Depending on the quantity required, the compound may be shipped via ground transportation, air freight, or ocean freight. It is essential to adhere to relevant regulations and guidelines for transporting hazardous chemicals to ensure compliance with safety standards.
⚠️ Safety Considerations
Safety considerations for N-Methyl-p-toluenesulfonamide include the necessity of handling the compound with adequate ventilation to prevent inhalation of vapors, as exposure to high concentrations can lead to respiratory irritation. Additionally, proper personal protective equipment such as gloves and goggles should be worn to minimize skin and eye contact with the substance. Care should also be taken to avoid ingestion or contact with open wounds, as N-Methyl-p-toluenesulfonamide may be harmful if swallowed or absorbed through the skin.
Hazard statements for N-Methyl-p-toluenesulfonamide include “Causes skin irritation” and “Causes serious eye irritation”, reflecting the potential risks associated with direct contact with the compound. These statements serve as warnings for individuals handling N-Methyl-p-toluenesulfonamide to take appropriate precautions to avoid skin and eye exposure, as well as to seek medical attention if contact occurs. It is important to adhere to these hazard statements in order to prevent adverse health effects.
Precautionary statements for N-Methyl-p-toluenesulfonamide emphasize the importance of wearing protective gloves, clothing, and eye/face protection when handling the compound to minimize the risk of skin and eye irritation. Additionally, it is recommended to wash hands thoroughly after handling and before eating, drinking, or using the restroom to prevent inadvertent ingestion of the substance. In case of accidental exposure, it is advised to seek medical advice immediately and provide the doctor with the safety data sheet for N-Methyl-p-toluenesulfonamide to ensure appropriate treatment. Taking these precautionary measures can help mitigate potential hazards associated with the compound.
🔬 Potential Research Directions
One potential research direction for N-Methyl-p-toluenesulfonamide is its application in medicinal chemistry. Investigating its potential as a pharmaceutical intermediate or as a building block for drug discovery could lead to the development of novel therapeutic agents.
Another avenue of research could focus on the environmental impact of N-Methyl-p-toluenesulfonamide. Studying its degradation pathways, toxicological effects, and potential for bioaccumulation could provide valuable information for risk assessment and regulatory guidelines.
Furthermore, exploring the use of N-Methyl-p-toluenesulfonamide in material science applications, such as in the synthesis of polymers or as a stabilizer in industrial processes, could open up new opportunities for innovation and commercialization. Its unique properties may provide advantages in specific applications compared to traditional chemicals.
🧪 Related Compounds
One similar compound to N-Methyl-p-toluenesulfonamide is N-Ethyl-p-toluenesulfonamide. This compound has a similar molecular structure to N-Methyl-p-toluenesulfonamide, with the only difference being the substitution of a methyl group with an ethyl group. N-Ethyl-p-toluenesulfonamide shares similar properties and uses with N-Methyl-p-toluenesulfonamide due to their structural similarity.
Another similar compound is N-Isopropyl-p-toluenesulfonamide, which also has a comparable molecular structure to N-Methyl-p-toluenesulfonamide. In this compound, the methyl group is replaced with an isopropyl group. N-Isopropyl-p-toluenesulfonamide exhibits similar characteristics and applications as N-Methyl-p-toluenesulfonamide, given their structural resemblance.
One more analogous compound is N-tert-Butyl-p-toluenesulfonamide. Like N-Methyl-p-toluenesulfonamide, this compound features a toluenesulfonamide core with a tert-butyl group in place of the methyl group. N-tert-Butyl-p-toluenesulfonamide can be used in similar applications to N-Methyl-p-toluenesulfonamide due to their structural kinship.
