N-Cyclohexylformamide is a chemical compound commonly used in the pharmaceutical industry and in the manufacturing of certain types of resins. While not a household name, this compound plays a significant role in the production of various medications and materials that may impact individuals’ everyday lives. Its importance lies in its versatility and wide range of applications, making it a crucial component in many industries that contribute to societal advancements and improvements in daily living.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
N-Cyclohexylformamide is commonly used in commercial and industrial applications as a solvent for resins, coatings, and dyes. It is also utilized as a chemical intermediate in the production of pharmaceuticals, agrochemicals, and other specialty chemicals. Due to its high boiling point and ability to dissolve a wide range of organic compounds, N-Cyclohexylformamide is a versatile ingredient in various manufacturing processes.
In the realm of drug and medication applications, N-Cyclohexylformamide is utilized as a key intermediate in the synthesis of pharmaceutical compounds. It is known to exhibit pharmacological properties and has been studied for its potential therapeutic uses. The chemical structure and properties of N-Cyclohexylformamide make it suitable for pharmaceutical development, particularly in the creation of new drugs for various medical conditions.
Overall, the commercial and industrial applications of N-Cyclohexylformamide are diverse and essential for various manufacturing processes. Its role as a solvent and chemical intermediate makes it a valuable component in the production of a wide range of products, from coatings and dyes to pharmaceuticals and agrochemicals. Its unique properties and versatility make it a crucial ingredient in numerous industries.
⚗️ Chemical & Physical Properties
N-Cyclohexylformamide is a colorless liquid with a distinct odor. It has a slight sweet smell similar to that of cyclohexane or benzaldehyde, but with a slightly mustier undertone.
With a molar mass of 141.21 g/mol and a density of 0.994 g/cm³ at 20°C, N-Cyclohexylformamide is heavier than common food items such as water (18.015 g/mol, 0.998 g/cm³) and ethanol (46.07 g/mol, 0.789 g/cm³).
N-Cyclohexylformamide has a melting point of -43°C and a boiling point of 240°C. This distinguishes it from common food items like sugar (melting point of 186°C) and butter (boiling point of 160°C), which have significantly different melting and boiling points.
N-Cyclohexylformamide is sparingly soluble in water and possesses a moderate viscosity. When compared to common food items like salt (very soluble in water) and honey (high viscosity), N-Cyclohexylformamide falls somewhere in between in terms of solubility and viscosity.
🏭 Production & Procurement
In the production of N-Cyclohexylformamide, the key starting material is cyclohexylamine. This is typically reacted with formic acid in the presence of a catalyst, such as para-toluenesulfonic acid, to form N-Cyclohexylformamide. The reaction commonly occurs under reflux conditions to ensure maximum conversion.
N-Cyclohexylformamide can be procured from chemical suppliers specializing in fine chemicals or specialty intermediates. It is typically available in liquid form and stored in sealed containers to prevent exposure to air and moisture. Transportation of N-Cyclohexylformamide is typically done in sealed drums or containers compliant with transportation regulations for hazardous materials.
When procuring N-Cyclohexylformamide, it is important to ensure compliance with safety regulations regarding handling and storage. Proper labeling and documentation are crucial when transporting the compound to prevent any mix-ups or accidents. Quality control measures should also be in place to verify the purity and consistency of the product before use in further chemical reactions.
⚠️ Safety Considerations
Safety considerations for N-Cyclohexylformamide should be taken seriously due to its potential hazards. The substance may cause skin irritation and eye irritation upon contact. Inhalation of vapors or dust may also lead to respiratory irritation. It is important to handle N-Cyclohexylformamide in a well-ventilated area and wear appropriate personal protective equipment, such as gloves and safety goggles, to minimize risks of exposure.
Hazard statements for N-Cyclohexylformamide include “Causes skin irritation” and “Causes serious eye irritation.” These statements indicate the potential hazards associated with direct contact with the substance. It is important to exercise caution when handling N-Cyclohexylformamide to avoid skin and eye irritation. Additionally, inhalation of vapors or dust should be prevented to minimize respiratory irritation.
Precautionary statements for N-Cyclohexylformamide include “Wear protective gloves/eye protection” and “Avoid breathing dust/fume/gas/mist/vapors/spray.” These statements emphasize the importance of using appropriate personal protective equipment when handling the substance. It is crucial to wear gloves and safety goggles to protect the skin and eyes from irritation. Adequate ventilation should also be provided to minimize inhalation of vapors or dust.
🔬 Potential Research Directions
Research on N-Cyclohexylformamide is still in its early stages, but there are several potential directions for further study. One area of interest could be the synthesis and characterization of novel derivatives of this compound, exploring their chemical and physical properties. Another avenue for research could focus on the development of new synthetic methodologies using N-Cyclohexylformamide as a key building block. Additionally, investigations into the biological activities and potential applications of N-Cyclohexylformamide derivatives could also be an exciting area of study.
Further studies could encompass the investigation of the reactivity and stability of N-Cyclohexylformamide in different chemical environments, which could provide valuable insights into its potential uses in various industrial processes. Additionally, exploring the potential applications of N-Cyclohexylformamide as a solvent or reagent in organic synthesis could lead to the development of more efficient and sustainable chemical reactions. Moreover, research on the environmental impact and toxicity profile of N-Cyclohexylformamide and its derivatives could also be important for assessing their safety and potential risks in various applications.
Furthermore, research on the potential catalytic capabilities of N-Cyclohexylformamide and its derivatives could open up opportunities for the development of new catalytic systems for organic transformations. Additionally, exploring the potential use of N-Cyclohexylformamide as a chiral auxiliary in asymmetric synthesis could lead to the development of more efficient methods for the synthesis of enantiopure compounds. Overall, the diverse range of potential research directions for N-Cyclohexylformamide highlights its versatility as a valuable building block in organic chemistry and underscores the importance of further investigations into its properties and applications.
🧪 Related Compounds
One similar compound to N-Cyclohexylformamide based upon molecular structure is N-Cyclopentylformamide. In this compound, the cyclohexane ring is replaced with a cyclopentane ring, resulting in a slightly smaller molecule with similar properties. N-Cyclopentylformamide may exhibit similar solubility, reactivity, and biological activity to N-Cyclohexylformamide due to the presence of the formamide functional group.
Another compound closely related to N-Cyclohexylformamide is N-Cyclooctylformamide. In this compound, the cyclohexane ring is replaced with a cyclooctane ring, leading to a larger molecule with similar structural characteristics. N-Cyclooctylformamide may share similar physical and chemical properties with N-Cyclohexylformamide, such as boiling point, melting point, and solubility, due to their comparable molecular structures.
N-Methylcyclohexylformamide is another compound similar to N-Cyclohexylformamide. In this compound, a methyl group is attached to the nitrogen atom of the formamide group, resulting in a slight modification to the molecular structure. N-Methylcyclohexylformamide may exhibit similar interactions with other molecules, enzymes, or receptors as N-Cyclohexylformamide due to the presence of the formamide moiety and the cyclohexyl group.
