N-(2-Ethoxyphenyl)acetamide, also known as acetaminophen, is a commonly used medication for relieving minor aches and pains, as well as reducing fever. Its relevance to everyday life lies in its widespread availability over-the-counter, making it easily accessible for individuals seeking relief from common ailments such as headaches, muscle aches, and fevers. Moreover, acetaminophen’s effectiveness and mild side effects profile make it a popular choice for managing everyday discomfort, contributing to its significance in many households and workplaces.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
N-(2-Ethoxyphenyl)acetamide, also known as phenacetin, has a variety of commercial and industrial applications. It is commonly used as an intermediate in the production of pharmaceuticals and dyes. Additionally, it is utilized as a precursor in the synthesis of other organic compounds.
In the field of medicine, N-(2-Ethoxyphenyl)acetamide has been historically used as an analgesic and antipyretic drug. It was commonly found in combination with other medications for pain relief and fever reduction. However, due to concerns about its potential for causing kidney damage and cancer, phenacetin was banned in many countries for use in medications.
Despite its ban in medication, N-(2-Ethoxyphenyl)acetamide still finds applications in research and development as a chemical reagent. Its properties make it useful in various organic chemistry reactions, allowing for the synthesis of new molecules for potential pharmaceutical or industrial use. Researchers continue to explore the potential of phenacetin derivatives in different fields, contributing to the advancement of science and technology.
⚗️ Chemical & Physical Properties
N-(2-Ethoxyphenyl)acetamide is a white crystalline solid with no distinct odor. It is commonly used as an intermediate in the synthesis of pharmaceutical compounds due to its stability and reactivity.
The molar mass of N-(2-Ethoxyphenyl)acetamide is approximately 179.21 g/mol, and its density is around 1.1 g/cm3. In comparison to common food items, N-(2-Ethoxyphenyl)acetamide has a higher molar mass and density than most organic compounds found in food.
The melting point of N-(2-Ethoxyphenyl)acetamide is around 50-55°C, while its boiling point is approximately 300-310°C. In contrast to common food items, N-(2-Ethoxyphenyl)acetamide has a higher melting point and boiling point than substances like sugar or salt.
N-(2-Ethoxyphenyl)acetamide is sparingly soluble in water and exhibits low viscosity. Compared to common food items, this compound’s solubility in water is lower, and its viscosity is higher than substances like vinegar or sugar syrup.
🏭 Production & Procurement
N-(2-Ethoxyphenyl)acetamide, also known as Phenacetin, is primarily synthesized through the esterification of para-ethoxyacetophenone with acetic anhydride. This reaction is typically catalyzed by sulfuric acid at elevated temperatures, resulting in the formation of N-(2-Ethoxyphenyl)acetamide as the final product.
The procurement of N-(2-Ethoxyphenyl)acetamide involves either purchasing it from chemical suppliers or manufacturing it in-house through the aforementioned synthetic route. The compound can be transported in solid form or as a solution in a suitable solvent, with proper handling precautions to ensure its stability during transit.
Due to its classification as a controlled substance in some jurisdictions, the procurement and transportation of N-(2-Ethoxyphenyl)acetamide may require adherence to regulatory requirements and licensing procedures. Careful consideration of safety measures and compliance with legal guidelines are essential in the handling and distribution of this compound.
⚠️ Safety Considerations
Safety Considerations for N-(2-Ethoxyphenyl)acetamide:
When handling N-(2-Ethoxyphenyl)acetamide, it is important to take necessary safety precautions to prevent potential harm. This chemical should be stored in a cool, dry place away from direct sunlight and heat sources. It is also important to wear appropriate personal protective equipment such as gloves, goggles, and a lab coat when working with this compound. In case of accidental contact with skin or eyes, immediate medical attention should be sought.
Hazard Statements for N-(2-Ethoxyphenyl)acetamide:
The hazard statements for N-(2-Ethoxyphenyl)acetamide include “Causes serious eye irritation” and “May cause respiratory irritation.” These statements indicate potential risks associated with exposure to this chemical, highlighting the importance of taking appropriate safety precautions when handling it. It is crucial to follow guidelines for safe storage, handling, and disposal to minimize the risk of harm.
Precautionary Statements for N-(2-Ethoxyphenyl)acetamide:
Precautionary statements for N-(2-Ethoxyphenyl)acetamide include “Wear protective gloves/eye protection” and “Avoid breathing dust/fume/gas/mist/vapors/spray.” These statements emphasize the importance of wearing appropriate personal protective equipment and ensuring adequate ventilation when working with this chemical. It is crucial to follow recommended safety practices to avoid potential hazards and protect against harmful effects.
🔬 Potential Research Directions
Research on N-(2-Ethoxyphenyl)acetamide could explore its potential applications as a novel drug compound for various medical conditions. Studies may investigate its pharmacological properties, including its efficacy, safety, and bioavailability in preclinical and clinical trials.
Furthermore, research could focus on elucidating the molecular mechanisms by which N-(2-Ethoxyphenyl)acetamide exerts its therapeutic effects. This could involve examining its interactions with specific biological targets, such as enzymes or receptors, to better understand its mode of action and potential side effects.
Additionally, investigations into the synthesis and optimization of N-(2-Ethoxyphenyl)acetamide derivatives may be pursued to enhance its pharmaceutical properties, such as solubility, stability, and target selectivity. This could lead to the development of more potent and effective analogs with improved bioavailability and reduced toxicity.
🧪 Related Compounds
One similar compound to N-(2-Ethoxyphenyl)acetamide based upon molecular structure is N-(2-Methoxyphenyl)acetamide. In this compound, the ethoxy group in N-(2-Ethoxyphenyl)acetamide is replaced with a methoxy group, resulting in a similar chemical structure. This substitution affects the compound’s physical and chemical properties, leading to differences in reactivity and biological activity.
Another compound with a similar structure to N-(2-Ethoxyphenyl)acetamide is N-(2-Hydroxyphenyl)acetamide. In this compound, the ethoxy group is replaced with a hydroxy group, resulting in a different functional group attached to the phenyl ring. This substitution can lead to changes in the compound’s solubility, stability, and interaction with other molecules, impacting its pharmacological properties.
One more compound akin to N-(2-Ethoxyphenyl)acetamide in terms of molecular structure is N-(2-Chlorophenyl)acetamide. In this compound, the ethoxy group is substituted with a chloro group, altering the compound’s electronic properties and reactivity. This modification can affect the compound’s biological activity and toxicity profile, highlighting the importance of structural variations in chemical compounds.