Methyl trifluoromethanesulfonate, a chemical compound commonly used as a reagent in organic synthesis, may not have direct relevance to everyday life for the average individual. However, its importance lies in its role in the pharmaceutical industry, where it is utilized in the production of various drugs and medicines. Additionally, methyl trifluoromethanesulfonate has applications in the fields of agrochemicals and materials science, contributing to advancements in agriculture and technology. While not a household name, this compound plays a critical role in driving innovation and progress in key industries that impact society as a whole.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
Methyl trifluoromethanesulfonate, an organofluorine compound, finds various commercial and industrial applications due to its unique chemical properties. One of its primary uses is as a fluorination reagent in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. Additionally, it is utilized in the manufacturing of specialty chemicals, such as dyes and surfactants, due to its high reactivity.
In the realm of drug and medication applications, Methyl trifluoromethanesulfonate plays a crucial role in the synthesis of fluorinated pharmaceuticals. This compound is often employed in the introduction of fluorine atoms into drug molecules to enhance their bioavailability, metabolic stability, and pharmacological properties. Furthermore, its use in medicinal chemistry has led to the development of novel therapeutic agents with improved efficacy and reduced side effects.
⚗️ Chemical & Physical Properties
Methyl trifluoromethanesulfonate appears as a colorless liquid with a distinct odor. It is a highly reactive compound commonly used in organic synthesis.
The molar mass of Methyl trifluoromethanesulfonate is approximately 174.09 g/mol, and its density is 1.521 g/cm³. When compared to common food items, such as water with a molar mass of 18.015 g/mol and a density of 1.00 g/cm³, Methyl trifluoromethanesulfonate is significantly heavier and denser.
Methyl trifluoromethanesulfonate has a melting point of -28 °C and a boiling point of 104-106 °C. These values are much lower than those of common food items like sugar, which has a melting point of 186 °C and a boiling point above 320 °C.
Methyl trifluoromethanesulfonate is sparingly soluble in water and exhibits low viscosity. Compared to common food items like salt, which is highly soluble in water, and honey, which has high viscosity, Methyl trifluoromethanesulfonate shows different solubility and viscosity properties.
🏭 Production & Procurement
Methyl trifluoromethanesulfonate (MTS) is commonly produced through the reaction of methyl iodide with sodium trifluoromethanesulfinate. This reaction typically takes place in an organic solvent and under carefully controlled conditions to ensure high yields and purity of the final product.
Once produced, Methyl trifluoromethanesulfonate can be procured from chemical suppliers who specialize in providing specialty reagents and intermediates to research laboratories and industrial facilities. The compound is typically packaged and shipped in sealed containers to prevent exposure to moisture and air, which can lead to degradation.
Transportation of Methyl trifluoromethanesulfonate is usually handled by specialized chemical transportation companies that are equipped to handle hazardous materials. The compound is categorized as a hazardous material due to its potential reactivity and toxicity, so strict safety regulations must be followed during transportation to prevent accidents and ensure the safety of handlers and the public.
⚠️ Safety Considerations
Safety considerations for Methyl trifluoromethanesulfonate must be taken into account due to its potential hazards. This chemical is corrosive and causes severe skin burns and eye damage. Inhalation of Methyl trifluoromethanesulfonate can lead to respiratory irritation and damage as well. Additionally, this compound is harmful if swallowed or absorbed through the skin, with potential long-term health effects.
Hazard statements for Methyl trifluoromethanesulfonate include “causes severe skin burns and eye damage” and “may be corrosive to metals.” It is also labeled as harmful if swallowed or inhaled, and may cause respiratory irritation. Moreover, this chemical is toxic to aquatic life with long-lasting effects.
Precautionary statements for Methyl trifluoromethanesulfonate recommend wearing protective gloves, clothing, eye protection, and face protection. It is advised to avoid breathing in the fumes, as well as avoiding release to the environment. In case of skin contact, it is important to rinse with water and seek medical advice. Additionally, caution should be exercised when handling this substance to prevent adverse effects on human health and the environment.
🔬 Potential Research Directions
Potential research directions for Methyl trifluoromethanesulfonate (MeOTf) include its application as a reagent in organic synthesis reactions, particularly in the installation of the trifluoromethylsulfonyl group.
Studies may also focus on the optimization of reaction conditions to enhance the efficiency and selectivity of MeOTf-mediated transformations, thereby expanding its utility in various chemical transformations.
Furthermore, research could explore the mechanism of the trifluoromethanesulfonylation reactions catalyzed by MeOTf, providing valuable insights into the reaction pathways and facilitating the development of new synthetic methodologies.
🧪 Related Compounds
One similar compound to Methyl trifluoromethanesulfonate is Ethyl trifluoromethanesulfonate. This compound has a similar molecular structure, with a trifluoromethanesulfonyl group attached to an ethyl group. Ethyl trifluoromethanesulfonate is commonly used as a reagent in various organic synthesis reactions.
Another compound with a similar structure is Isopropyl trifluoromethanesulfonate. This compound contains a trifluoromethanesulfonyl group attached to an isopropyl group. Isopropyl trifluoromethanesulfonate is often employed in organic reactions for its ability to act as a mild electrophile.
A third comparable compound is Propyl trifluoromethanesulfonate. This compound features a trifluoromethanesulfonyl group attached to a propyl group. Propyl trifluoromethanesulfonate is utilized in organic synthesis as a reagent for various transformations due to its unique chemical properties.
