Imidazole acetol-phosphate is a crucial intermediate in the biosynthetic pathway of histidine, an essential amino acid. Histidine plays a pivotal role in various biological processes, including protein synthesis and enzymatic reactions. Therefore, the relevance of imidazole acetol-phosphate lies in its contribution to the production of histidine, ultimately impacting human health and vitality. Its significance extends to everyday life, as histidine is essential for proper growth, tissue repair, and overall physiological function.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
Imidazole acetol-phosphate is a compound primarily utilized in the commercial and industrial sectors for its role as a key intermediate in the biosynthesis of histidine. This important amino acid is essential for protein synthesis and various metabolic processes, making imidazole acetol-phosphate a valuable component in the production of food additives, pharmaceuticals, and other biochemical products.
In the realm of drug and medication applications, imidazole acetol-phosphate plays a critical role in the development of histidine biosynthesis inhibitors. These inhibitors are used in the treatment of certain bacterial infections by targeting the specific metabolic pathway responsible for histidine production. By disrupting this pathway, these inhibitors can effectively inhibit bacterial growth and reproduction, making them valuable in the fight against infectious diseases.
⚗️ Chemical & Physical Properties
Imidazole acetol-phosphate appears as a white crystalline powder with no distinct odor.
It has a molar mass of approximately 217.1 g/mol and a density of about 1.49 g/cm3. In comparison to common household items, Imidazole acetol-phosphate has a higher molar mass and density, making it denser and heavier than most everyday materials.
The melting point of Imidazole acetol-phosphate is around 177-180°C, while the boiling point is approximately 335-340°C. Compared to common household items, its melting and boiling points are much higher, indicating a greater stability under heat.
Imidazole acetol-phosphate is moderately soluble in water and has a low viscosity. When compared to common household items, it has higher solubility in water and lower viscosity, making it easier to dissolve and less thick in texture.
🏭 Production & Procurement
Imidazole acetol-phosphate is primarily produced through enzymatic reactions in living organisms. This molecule is a key intermediate in the histidine biosynthesis pathway, where it is synthesized from phosphoribosyl-ATP and imidazole aldol-phosphate. This process typically occurs within the cells of bacteria, fungi, and plants.
Procurement of Imidazole acetol-phosphate for research purposes can be achieved through chemical synthesis or extraction from biological sources. Chemical synthesis involves the stepwise assembly of the molecule from commercially available starting materials using established organic chemistry techniques. Alternatively, Imidazole acetol-phosphate can be extracted from genetically engineered microorganisms that overproduce the intermediate.
For transport and storage, Imidazole acetol-phosphate must be handled with care due to its sensitivity to light and air. The compound is typically stored in dark, airtight containers at low temperatures to prevent degradation. When transporting Imidazole acetol-phosphate, it is important to ensure that the container is securely sealed and protected from exposure to external elements.
⚠️ Safety Considerations
Safety Considerations for Imidazole acetol-phosphate:
When working with Imidazole acetol-phosphate, it is important to adhere to proper safety precautions to prevent any accidental exposure. This compound should be handled in a well-ventilated area to minimize inhalation and skin contact risks. Personal protective equipment, such as gloves and safety goggles, should be worn at all times when handling Imidazole acetol-phosphate to avoid any potential skin or eye irritation.
It is also crucial to store Imidazole acetol-phosphate in a secure location away from incompatible materials to prevent any accidental reactions. Proper labeling of containers containing this compound is necessary to ensure that individuals are aware of its contents and potential hazards. In case of any accidental exposure or ingestion, it is important to seek medical attention immediately and provide the necessary information about the compound to healthcare professionals.
Pharmacology of Imidazole acetol-phosphate:
Imidazole acetol-phosphate is a key intermediate in the histidine biosynthesis pathway in various organisms, including bacteria and plants. This compound plays a crucial role in the conversion of imidazole acetol-phosphate to histidine, an essential amino acid for protein synthesis. Imidazole acetol-phosphate is involved in regulating the expression of genes related to histidine biosynthesis, making it a vital component in cellular metabolism.
Hazard Statements for Imidazole acetol-phosphate:
Imidazole acetol-phosphate may cause skin irritation and eye irritation upon contact, as well as respiratory irritation if inhaled. This compound is harmful if swallowed and may cause gastrointestinal irritation, nausea, vomiting, and diarrhea. Prolonged or repeated exposure to Imidazole acetol-phosphate may lead to adverse health effects, including allergic reactions or sensitization in certain individuals.
Precautionary Statements for Imidazole acetol-phosphate:
When working with Imidazole acetol-phosphate, it is important to wash hands thoroughly after handling to prevent any potential skin irritation or sensitization. Avoid inhaling the dust or vapor of this compound, as it may cause respiratory irritation. In case of any contact with skin or eyes, rinse thoroughly with water and seek medical attention if irritation persists. Store Imidazole acetol-phosphate in a cool, dry place away from heat sources and direct sunlight to prevent any degradation of the compound.
🔬 Potential Research Directions
One potential research direction for imidazole acetol-phosphate is exploring its role in metabolic pathways and enzymatic reactions. Understanding its biochemical functions can provide insights into its involvement in cellular processes and disease mechanisms.
Another avenue of research could involve investigating the molecular targets and binding interactions of imidazole acetol-phosphate. Identifying specific proteins or compounds that interact with imidazole acetol-phosphate can shed light on its biological significance and potential therapeutic applications.
Furthermore, studying the synthesis and metabolism of imidazole acetol-phosphate in different organisms can offer valuable information on its evolutionary conservation and adaptation. Comparative studies across species can help elucidate the biochemistry and physiological functions of imidazole acetol-phosphate in diverse biological systems.
🧪 Related Compounds
One similar compound to Imidazole acetol-phosphate based upon molecular structure is Imidazole glycerol-phosphate. This compound also contains an imidazole ring and a phosphate group, similar to Imidazole acetol-phosphate. Imidazole glycerol-phosphate plays a crucial role in the biosynthesis of histidine in microorganisms.
Another compound with a similar structure is Imidazole ribotide. Imidazole ribotide is an intermediate in the de novo purine synthesis pathway. It contains an imidazole ring and a ribose unit, similar to Imidazole acetol-phosphate. Imidazole ribotide is involved in the conversion of inosine monophosphate to adenosine monophosphate.
Furthermore, Histidyl-adenylate is another compound related to Imidazole acetol-phosphate based on molecular structure. Histidyl-adenylate contains an imidazole group and an adenosine monophosphate unit. This compound is a key intermediate in histidine biosynthesis, serving as a precursor to histidyl-tRNA. Imidazole acetol-phosphate, Imidazole glycerol-phosphate, Imidazole ribotide, and Histidyl-adenylate are all structurally related compounds involved in various biochemical processes.
