Heptafluorobutyramide, a fluorinated amide compound, may not be a common household name, but its relevance extends to various industries and everyday life. This chemical is commonly used as a solvent in organic synthesis and as a derivatization reagent in analytical chemistry. In the pharmaceutical industry, Heptafluorobutyramide plays a crucial role in the synthesis of certain drug molecules. Additionally, it is employed in the production of coatings, adhesives, and other specialty chemicals. Its unique properties make it valuable in research and development, paving the way for advancements in various sectors that ultimately impact our daily lives.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
Heptafluorobutyramide, also known as HFBA, has several commercial and industrial applications due to its unique properties. It is commonly used as a derivatization reagent in gas chromatography-mass spectrometry (GC-MS) analysis for the determination of various compounds. HFBA is also utilized as a coupling agent in peptide synthesis and as a reagent for the determination of alcohols and carboxylic acids.
In addition to its commercial and industrial applications, Heptafluorobutyramide has found utility in the field of drug and medication analysis. It is commonly used as a derivatization reagent for the analysis of drugs and metabolites in biological samples. HFBA can improve the sensitivity and selectivity of analytical methods, making it a valuable tool in pharmaceutical research and development.
Overall, Heptafluorobutyramide plays a crucial role in various industries and scientific fields due to its versatility and effectiveness as a derivatization reagent. Its applications in gas chromatography, peptide synthesis, and drug analysis highlight its importance as a valuable chemical reagent in modern research and development.
⚗️ Chemical & Physical Properties
Heptafluorobutyramide is a white crystalline solid with a slight, characteristic odor. It is synthesized through the reaction of heptafluorobutyric anhydride with ammonia, resulting in a compound with a flake-like appearance and a subtle scent.
With a molar mass of 233.07 g/mol and a density of approximately 1.292 g/cm³, heptafluorobutyramide is heavier than common food items like water (18.02 g/mol) and sugar (342.3 g/mol), but less dense than many oils and fats. This gives it unique physical properties in comparison to everyday substances found in the kitchen.
Heptafluorobutyramide has a melting point of around 58-60°C and a boiling point of approximately 208-210°C. These values lie within a range that is higher than most common food items such as sugar (m.p. 160-186°C) and water (b.p. 100°C), highlighting the compound’s thermodynamic stability and resistance to changes in temperature.
Heptafluorobutyramide exhibits low solubility in water but is readily soluble in organic solvents like acetone and ethanol. It has a high viscosity at room temperature, similar to thick syrups or oils, making it distinct from common food items that often have lower viscosities and higher water solubilities.
🏭 Production & Procurement
Heptafluorobutyramide, a chemical compound utilized in various industrial applications, is typically produced through a multistep synthesis process. The synthesis involves reactions between heptafluorobutyric acid and various amine derivatives, resulting in the formation of Heptafluorobutyramide.
To procure Heptafluorobutyramide, one can generally turn to chemical suppliers or manufacturers specializing in the production and distribution of specialty chemicals. The compound is typically available in varying purities and quantities, depending on the specific requirements of the end user.
Once procured, Heptafluorobutyramide can be transported in sealed containers to ensure its stability and prevent contamination. The compound should be handled with care and stored in a cool, dry place to maintain its integrity and avoid degradation during transportation and storage.
⚠️ Safety Considerations
Safety considerations for Heptafluorobutyramide should include its potential for irritation to the skin, eyes, and respiratory tract upon contact or inhalation. It is recommended to handle this compound with gloves, safety goggles, and a lab coat to prevent direct exposure. Additionally, proper ventilation in the laboratory or workspace is crucial to minimize the risk of inhalation of vapors.
The hazard statements for Heptafluorobutyramide typically include warnings about its potential for skin and eye irritation, as well as respiratory irritation if inhaled. It may also pose a risk of harm to aquatic life if released into the environment. Therefore, it is important to handle this compound with care and follow proper safety protocols to prevent any adverse effects on human health and the environment.
Precautionary statements for Heptafluorobutyramide may include advice to avoid direct contact with skin, eyes, and clothing to prevent irritation. It is also recommended to use this compound in a well-ventilated area to minimize the risk of inhalation. Proper storage in a cool, dry place away from incompatible substances is essential to prevent any potential reactions or accidents. Additionally, it is advised to dispose of any unused or waste material in accordance with local regulations to ensure proper handling and containment.
🔬 Potential Research Directions
Potential research directions for Heptafluorobutyramide include its use as a fluorinated building block in organic synthesis. Researchers may also investigate its potential as a reagent in various chemical reactions, such as amidation and acylation processes. Additionally, studies could explore its applications in drug discovery and material science due to its unique chemical properties.
Further research could focus on the development of new methods for the synthesis of Heptafluorobutyramide, such as improving the efficiency and yield of current synthetic routes. Investigations into the reactivity and stability of Heptafluorobutyramide under various conditions could also provide valuable insights for its practical applications. Additionally, studies on the toxicity and environmental impact of Heptafluorobutyramide may be necessary for its safe handling and disposal.
Exploring the potential use of Heptafluorobutyramide in catalysis, particularly in asymmetric reactions, could open up new avenues for its application in the field of organic chemistry. Investigations into the functional group compatibility of Heptafluorobutyramide with other reagents and substrates could also lead to the development of novel synthetic methodologies. Moreover, studies on the mechanism of reactions involving Heptafluorobutyramide could provide a deeper understanding of its reactivity and potential limitations.
🧪 Related Compounds
One similar compound to Heptafluorobutyramide based on molecular structure is Heptafluorobutyronitrile. This compound, like Heptafluorobutyramide, contains a butyryl functional group with seven fluorine atoms attached to the carbon backbone. Heptafluorobutyronitrile is used as a solvent, reagent, and intermediate in organic synthesis.
Another compound with a similar structure to Heptafluorobutyramide is Heptafluorobutyraldehyde. This compound also contains a butyryl functional group with seven fluorine atoms attached to the carbon chain. Heptafluorobutyraldehyde is commonly used in the manufacture of pharmaceuticals, agrochemicals, and as a solvent in various chemical reactions.
A further compound that shares a similar molecular structure with Heptafluorobutyramide is Heptafluorobutyric acid. This compound contains a butyryl group with seven fluorine atoms attached to the carbon chain, similar to Heptafluorobutyramide. Heptafluorobutyric acid is utilized in various industries as a solvent, corrosion inhibitor, and as a precursor in the synthesis of other fluorinated compounds.
