Ethanesulfonyl chloride, a chemical compound commonly used in organic synthesis and in the pharmaceutical industry, plays a significant role in everyday life through its various applications. It is utilized in the manufacturing of pharmaceuticals, agrochemicals, and plastics, among other products. Its versatile properties make it a crucial component in the production of a wide range of consumer goods, thus highlighting its relevance to everyday life.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
Ethanesulfonyl chloride, also known as methanesulfonyl chloride, has several commercial and industrial applications. It is commonly used as a reagent in the synthesis of various organic compounds, such as sulfonamides, sulfonate esters, and sulfonic acids. This compound is also utilized in the production of pharmaceuticals, pesticides, and dyes due to its ability to introduce the sulfonamide group into molecules.
In addition to its commercial and industrial uses, ethanesulfonyl chloride is employed in the pharmaceutical industry for drug and medication applications. It serves as a valuable building block for the synthesis of sulfonamides, which are used in the development of various pharmaceutical products. This compound is crucial in the preparation of sulfa drugs, which are antibiotics that inhibit the growth of bacteria by interfering with the synthesis of folic acid.
Overall, ethanesulfonyl chloride plays a significant role in both commercial and industrial sectors, as well as in drug and medication applications. Its versatile nature as a reagent for organic synthesis and pharmaceutical production highlights its importance in various fields. Whether used for creating new organic compounds or developing essential medications, this compound remains a valuable resource for researchers and manufacturers alike.
⚗️ Chemical & Physical Properties
Ethanesulfonyl chloride is a colorless liquid that has a sharp, pungent odor. It is highly reactive and is used in various chemical processes as a sulfonylating agent.
With a molar mass of 116.5 g/mol and a density of 1.21 g/cm3, ethanesulfonyl chloride is heavier than common food items such as water (molar mass: 18.0 g/mol, density: 1.0 g/cm3) and table salt (molar mass: 58.44 g/mol, density: 2.16 g/cm3).
Ethanesulfonyl chloride has a melting point of -66°C and a boiling point of 162-164°C, which are significantly higher compared to common food items like butter (melting point: 32-35°C) and vegetable oil (boiling point: ~320°C).
Ethanesulfonyl chloride is not soluble in water but is miscible in various organic solvents. It has a low viscosity, similar to common food items like vinegar. However, its solubility and viscosity properties differ significantly from water, which is highly soluble and has a low viscosity.
🏭 Production & Procurement
Ethanesulfonyl chloride, also known as ethylsulfonyl chloride or ESCl, is primarily produced through the chlorosulfonation of ethane. This process involves the reaction of ethylene with sulfuric acid and chlorine gas at high temperatures. The resulting Ethanesulfonyl chloride is then separated and purified through distillation.
Ethanesulfonyl chloride can be procured from chemical suppliers or manufacturers, who typically produce it in large quantities for industrial use. It is commonly available in liquid form and is stored and transported in sealed containers to prevent evaporation or leakage. Ethanesulfonyl chloride is a reactive compound that must be handled with care due to its corrosive and toxic nature.
When transporting Ethanesulfonyl chloride, precautions must be taken to ensure the safety of the handlers and prevent accidental exposure. It is typically shipped in specialized containers designed to withstand the corrosive properties of the compound. Proper labeling and documentation are required to comply with regulations governing the transportation of hazardous materials. Regulatory guidelines should be followed to minimize risks and ensure the safe handling of Ethanesulfonyl chloride throughout the supply chain.
⚠️ Safety Considerations
Safety considerations for Ethanesulfonyl chloride should be taken seriously due to its potential hazards. This compound is corrosive and can cause severe skin burns and eye damage upon contact. It is also harmful if inhaled or swallowed, leading to respiratory tract irritation and gastrointestinal issues. Ethanesulfonyl chloride should be handled with care in a well-ventilated area, using appropriate personal protective equipment such as gloves, goggles, and a lab coat.
Hazard statements for Ethanesulfonyl chloride include “causes severe skin burns and eye damage” and “may be corrosive to metals.” These statements highlight the compound’s potential to cause harm upon contact, emphasizing the importance of proper handling and storage procedures. It is crucial to minimize exposure to Ethanesulfonyl chloride to prevent accidents and ensure the safety of individuals working with this chemical.
Precautionary statements for handling Ethanesulfonyl chloride include wearing protective gloves, clothing, and eye/face protection. It is important to work in a well-ventilated area and avoid breathing in the compound’s fumes. In case of skin contact, immediate removal of contaminated clothing and thorough washing of the affected area is recommended. If exposed to Ethanesulfonyl chloride, seek medical attention and provide the relevant safety data sheet to healthcare professionals for proper treatment. These precautions are essential in preventing accidents and minimizing the risks associated with working with Ethanesulfonyl chloride.
🔬 Potential Research Directions
One potential research direction for Ethanesulfonyl chloride could be its exploration as a key intermediate in the synthesis of pharmaceutical compounds, agrochemicals, and materials for industrial applications.
Researchers may also investigate its reactivity and potential for functionalization, leading to the development of novel organic transformations and synthetic methodologies.
Furthermore, studies on the environmental impact of Ethanesulfonyl chloride during its production, use, and disposal could shed light on its sustainability and guide the development of greener synthetic routes.
🧪 Related Compounds
One similar compound to Ethanesulfonyl chloride based upon molecular structure is Methanesulfonyl chloride. This compound contains a methyl group attached to a sulfonyl chloride functional group, similar to Ethanesulfonyl chloride. Methanesulfonyl chloride is commonly used as a reagent in organic synthesis for various transformations.
Another compound with a similar structure is Propanesulfonyl chloride. This compound contains a longer alkyl chain compared to Ethanesulfonyl chloride, with a propyl group attached to a sulfonyl chloride functional group. Propanesulfonyl chloride shares similar reactivity and uses in organic chemistry as Ethanesulfonyl chloride.
A compound with a slightly different structure but similar reactivity is Benzenesulfonyl chloride. This compound contains a benzene ring attached to a sulfonyl chloride group, providing aromatic character to the molecule. Benzenesulfonyl chloride is commonly used as a protecting group in organic synthesis and as a reagent in various transformations.