Cinchophen 

Cinchophen, a drug once commonly used as an analgesic and antipyretic, may seem obsolete in modern medicine. However, understanding its historical significance underscores the evolution of pharmaceuticals and the ongoing advancement of medical treatments. Furthermore, examining the rise and fall of Cinchophen highlights the importance of rigorous testing and regulation in ensuring the safety and efficacy of medications for everyday use.

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💡  Commercial Applications

Cinchophen, a chemical compound with the molecular formula C11H10N2O2, has seen varied commercial and industrial applications. In the past, it was used as an analgesic and antipyretic agent. Its ability to reduce pain and fever made it popular for use in over-the-counter medications. However, due to potential safety concerns, its use in pharmaceuticals has largely been discontinued.

In industrial settings, Cinchophen has been utilized as a reagent in the synthesis of various organic compounds. Its structure and properties make it suitable for reactions involving aromatic systems. Additionally, it has been investigated for potential use as a dye intermediate, with studies exploring its potential applications in the textile industry.

Despite its limited commercial and industrial use, Cinchophen has historical significance in the field of medicine. It was once prescribed for various conditions such as arthritis, gout, and rheumatic fever. However, concerns about its toxic effects, particularly on the liver, led to its withdrawal from pharmaceutical use. Today, it is no longer recommended for medical treatment due to these safety issues.

⚗️  Chemical & Physical Properties

Cinchophen, also known as 2-(4-chlorophenylcarbamoyl)benzoic acid, is a white crystalline powder with a slightly bitter taste and no distinct odor.

With a molar mass of approximately 309.74 g/mol and a density of around 1.4 g/cm³, cinchophen is comparable in molar mass to common food items like sugar (180.16 g/mol) and in density to water (1 g/cm³).

Cinchophen has a melting point of about 210-215°C and a boiling point of around 460°C. These values are much higher than those of common food items like butter (melting point around 32°C) and water (boiling point at 100°C).

Cinchophen is sparingly soluble in water and has a relatively high viscosity. This differs significantly from common food items like salt (readily soluble in water) and honey (high viscosity), making cinchophen distinct in its solubility and viscosity properties.

🏭  Production & Procurement

Cinchophen is produced through a multi-step chemical synthesis process that combines various raw materials and reagents. The process involves several key reactions and purification steps to yield the final product, which is a white crystalline powder.

Cinchophen can be procured from specialized chemical manufacturers that produce and distribute the compound for industrial and research purposes. It can be purchased in bulk quantities or smaller quantities, depending on the intended use. The compound is typically transported in sealed containers to prevent contamination and ensure its integrity during transit.

In addition to direct procurement from manufacturers, Cinchophen can also be sourced through chemical distributors and suppliers that carry a range of chemical compounds and materials. These suppliers facilitate the procurement process by offering a convenient and efficient way to access a variety of chemical products, including Cinchophen. Customers can place orders through online portals or contact sales representatives for assistance.

⚠️  Safety Considerations

Safety considerations for Cinchophen include potential hazards such as skin and eye irritation. It is important to handle Cinchophen with caution and avoid direct contact with the skin or eyes. Proper personal protective equipment, such as gloves and goggles, should be worn when handling Cinchophen to minimize the risk of exposure.

In terms of hazard statements, Cinchophen may cause skin irritation and serious eye damage. It is also harmful if swallowed and can be toxic to aquatic life with long-lasting effects. Cinchophen should be handled and stored in a manner that reduces the risk of exposure to these hazards. Proper disposal methods should also be followed to prevent environmental contamination.

Precautionary statements for Cinchophen include avoiding contact with skin and eyes and wearing appropriate protective equipment when handling the compound. It is important to wash hands thoroughly after handling Cinchophen and to ensure that any contaminated clothing is removed promptly. In case of ingestion, immediate medical attention should be sought. Additionally, spillages should be cleaned up promptly and disposed of in accordance with local regulations to prevent environmental harm.

🔬  Potential Research Directions

Research on Cinchophen, a drug with a history of use in the treatment of rheumatoid arthritis, holds promise for further exploration into its potential pharmacological properties. Investigating its mechanism of action on inflammatory pathways may lead to a better understanding of its efficacy in managing inflammatory conditions.

Exploring the potential side effects and adverse reactions of Cinchophen, particularly in light of its historical associations with hepatotoxicity, could provide valuable insights for the development of safer and more effective therapeutics. Experimental studies on the metabolic fate of Cinchophen in humans and animal models may shed light on its biodistribution and elimination pathways.

Furthermore, clinical trials assessing the therapeutic potential of Cinchophen in modern disease contexts, such as autoimmune disorders or chronic inflammatory conditions, could help elucidate its relevance in contemporary medical practice. Research on novel drug delivery systems or targeted drug formulations for Cinchophen may also enhance its therapeutic efficacy while minimizing potential toxicity risks.

One similar compound to Cinchophen based upon molecular structure is Dichlophenac. This compound contains a similar chemical structure with a dichlorophenyl moiety and a carboxyl group. Dichlophenac is commonly used as a nonsteroidal anti-inflammatory drug and is known for its analgesic and anti-inflammatory properties.

Another compound similar to Cinchophen is Sulfinpyrazone. This compound also contains a similar chemical structure with a phenyl ring linked to a sulfinyl group. Sulfinpyrazone is commonly used to treat gout and hyperuricemia by inhibiting the reabsorption of uric acid in the kidneys. Its mechanism of action involves reducing the serum urate levels in the body.

Additionally, Oxypurinol is another compound similar to Cinchophen based on its molecular structure. This compound is an active metabolite of Allopurinol and contains a similar chemical structure with a xanthine moiety. Oxypurinol works by inhibiting xanthine oxidase, thereby reducing the production of uric acid in the body. It is commonly used for the treatment of gout and hyperuricemia.

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