Anthranilic acid, also known as 2-aminobenzoic acid, holds significant relevance in everyday life due to its various applications in industries such as pharmaceuticals, dyes, and food additives. It serves as a precursor in the synthesis of essential chemicals like saccharin, indigo, and certain pharmaceutical drugs. Additionally, anthranilic acid is utilized as a flavor enhancer in the food industry and plays a crucial role in the development of various fragrances. Its versatile properties and wide-ranging applications highlight the importance of this compound in various aspects of daily life.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
Anthranilic acid, also known as 2-aminobenzoic acid, has various commercial and industrial applications. It is commonly used in the production of dyes, perfumes, and pharmaceuticals due to its aromatic properties. Anthranilic acid is also utilized in the synthesis of UV stabilizers for plastics and polymers, as well as in the manufacture of certain agrochemicals.
In the realm of drug and medication applications, Anthranilic acid is a key building block in the synthesis of a variety of pharmaceuticals. It is used in the production of antimalarial drugs such as chloroquine, as well as in the synthesis of certain nonsteroidal anti-inflammatory drugs (NSAIDs) like mefenamic acid. Additionally, Anthranilic acid serves as a precursor in the formulation of Amiloride, a medication commonly used to treat high blood pressure and heart failure.
⚗️ Chemical & Physical Properties
Anthranilic acid, also known as 2-aminobenzoic acid, appears as a white crystalline solid with a slight odor. It is commonly used in the manufacturing of dyes and pharmaceuticals due to its chemical properties.
The molar mass of Anthranilic acid is approximately 137.14 g/mol, while its density is around 1.41 g/cm3. This places Anthranilic acid in the range of typical organic compounds in terms of molar mass and density, similar to substances found in common household items.
Anthranilic acid has a melting point of 144-145°C and a boiling point of 362-364°C. These values are higher than those of many common household items, such as sugar or salt, which typically have lower melting and boiling points.
Anthranilic acid is sparingly soluble in water, with a viscosity similar to that of other organic compounds. This level of solubility in water and viscosity is comparable to substances found in common household items, such as certain organic solvents or oils.
🏭 Production & Procurement
Anthranilic acid is typically produced through the process of nitration and reduction of phthalic anhydride. Phthalic anhydride undergoes nitration to form phthalic acid, which is then reduced to anthranilic acid using a reducing agent like iron or tin. This method yields high purity anthranilic acid suitable for various industrial applications.
Anthranilic acid can be procured from chemical suppliers who specialize in providing a wide range of organic compounds. It is commonly available in crystalline form as a white to slightly yellow powder. The compound is typically transported in sealed containers to prevent contamination and degradation during handling and storage. Proper labeling and Hazard Communication Standard compliance are essential for safe transportation of anthranilic acid.
In addition to purchasing anthranilic acid from chemical suppliers, it can also be synthesized in-house by skilled chemists in research laboratories or manufacturing facilities. This approach allows for greater control over the production process and quality of the final product. Specialized equipment and expertise are required to carry out the nitration and reduction reactions efficiently and safely. Overall, both procurement and production methods play a vital role in ensuring a steady supply of anthranilic acid for various applications.
⚠️ Safety Considerations
Safety considerations for Anthranilic acid primarily revolve around its potential for causing irritation to the skin, eyes, and respiratory tract. It is important to handle the compound with care, wearing appropriate personal protective equipment such as gloves and goggles. In case of exposure, it is recommended to rinse affected areas with water and seek medical attention if necessary. Additionally, Anthranilic acid should be stored in a cool, dry place away from incompatible materials to prevent accidents.
The pharmacology of Anthranilic acid involves its role as a precursor in the synthesis of pharmaceuticals and dyes. It is commonly used in the production of anti-inflammatory drugs, antispasmodics, and analgesics. Anthranilic acid has been studied for its potential therapeutic effects in various conditions, including cancer and neurological disorders. Its pharmacological properties make it a valuable compound in the field of drug development.
Hazard statements related to Anthranilic acid include its classification as a skin irritant and eye irritant. Prolonged or repeated exposure to the compound may cause damage to the skin and eyes. In case of contact, it is important to wash the affected area thoroughly and seek medical advice if irritation persists. Handling Anthranilic acid without proper precautions may lead to adverse health effects and should be avoided.
Precautionary statements for Anthranilic acid include the recommendation to wear protective clothing, gloves, and eye protection when handling the compound. Adequate ventilation should be ensured in work areas to prevent inhalation of vapors or dust. It is also important to avoid ingestion and to wash hands thoroughly after handling Anthranilic acid. Spills should be cleaned up promptly, and contaminated clothing should be removed and washed before reuse. Regular training on safe handling practices should be provided to individuals working with Anthranilic acid to minimize the risk of exposure.
🔬 Potential Research Directions
One potential research direction for Anthranilic acid is its role in pharmaceutical development. Studies have shown that Anthranilic acid derivatives have various pharmacological activities, such as anti-inflammatory and analgesic properties. Further research could explore the potential therapeutic applications of these derivatives.
Another avenue for research on Anthranilic acid is its use in the synthesis of various organic compounds. Anthranilic acid is a versatile building block in organic chemistry, and its derivatives can be used to create a wide range of molecules with diverse functionalities. Investigating new synthetic routes involving Anthranilic acid could lead to the discovery of novel compounds with valuable properties.
Additionally, Anthranilic acid has been implicated in different biological processes, including its role as a precursor in the biosynthesis of tryptophan. Given its biological significance, further studies could focus on understanding the mechanisms of Anthranilic acid metabolism and its interactions with other biomolecules. Exploring the biochemical pathways involving Anthranilic acid may provide insights into its functions in living organisms.
🧪 Related Compounds
One compound similar to Anthranilic acid is Phthalimide, which has the same molecular structure as Anthranilic acid, except it has an additional carbonyl group attached to the nitrogen atom. This compound is commonly used in the synthesis of various pharmaceuticals and agricultural chemicals due to its versatile reactivity. Phthalimide is a white solid that is soluble in water and exhibits amphoteric behavior in aqueous solutions.
Another compound with a similar structure to Anthranilic acid is Benzamide, which has a benzene ring connected to an amide functional group. Benzamide is commonly utilized as a building block in various chemical syntheses due to its stability and reactivity. This compound is a colorless solid that is soluble in polar organic solvents and exhibits weakly acidic behavior in aqueous solutions.
An additional compound akin to Anthranilic acid is Naphthalene-1,5-diamine, which contains two amino groups attached to a naphthalene ring. This compound is used in the production of various dyes, particularly azo dyes, due to its ability to form colored complexes. Naphthalene-1,5-diamine is a solid material that is sparingly soluble in water but more soluble in organic solvents, making it suitable for diverse applications in the chemical industry.
