Acetanilide, a chemical compound commonly used in the production of pharmaceuticals, dyes, and rubber products, holds relevance in everyday life due to its analgesic properties. The compound has been historically utilized in the synthesis of pain-relieving medications such as paracetamol, making it an integral component in the pharmaceutical industry. Additionally, Acetanilide is integral in the stable and efficient production of dyes and rubber products, contributing to the vibrant colors in textiles and the durability of various rubber goods that individuals encounter in their daily lives. Its versatility and utility in these industries underscore the significance of Acetanilide in modern society.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
Acetanilide, also known as N-phenylacetamide, has various commercial and industrial applications. One of the main uses of acetanilide is as an intermediate in the production of dyes and pharmaceuticals. It is also utilized in the manufacturing of rubber chemicals and antioxidants.
In the realm of drug and medication applications, acetanilide has historically been employed as an analgesic and antipyretic agent. It was one of the first synthetic drugs used for treating fevers and headaches. However, due to its toxic effects on the liver and other organs, acetanilide has largely been replaced by safer alternatives in modern medicine.
Overall, acetanilide remains relevant in the realm of organic chemistry and industrial synthesis. Its versatile properties and chemical structure make it a valuable compound in various industrial processes and pharmaceutical formulations. Despite its historical significance in medicine, its use has diminished due to safety concerns and the availability of more effective and less toxic alternatives.
⚗️ Chemical & Physical Properties
Acetanilide is a white crystalline solid with a faint odor reminiscent of camphor. It is commonly found in its solid form and is sparingly soluble in water. The pure substance has a melting point of approximately 113°C.
With a molar mass of 135.17 g/mol and a density of 1.219 g/cm³, Acetanilide falls within the range of common household items such as baking soda (molar mass of 84.01 g/mol) and sugar (density of 1.59 g/cm³). However, it is significantly denser than water (density of 1 g/cm³).
Acetanilide has a boiling point of approximately 304°C, higher than common household items such as ethanol (boiling point of 78°C) and vinegar (boiling point of 100°C). It exhibits low solubility in water but is soluble in organic solvents.
In terms of viscosity, Acetanilide has a relatively low viscosity compared to common household items like honey or molasses. It forms a clear solution in organic solvents and exhibits some thermal stability at higher temperatures.
🏭 Production & Procurement
Acetanilide, also known as N-phenylacetamide, is produced through the chemical reaction of acetic anhydride with aniline under reflux conditions. This process results in the formation of a crude product, which can be purified by recrystallization to obtain pure Acetanilide in a solid form.
Acetanilide can be procured from chemical suppliers that specialize in providing laboratory reagents and intermediates for organic synthesis. The compound is typically stored and transported in sealed containers to prevent exposure to moisture and other contaminants that may degrade its quality. Due to its low melting point, care must be taken to prevent Acetanilide from solidifying during transit.
In industrial settings, Acetanilide may be obtained through bulk chemical suppliers that produce and distribute large quantities of the compound for various applications, such as in the manufacturing of pharmaceuticals and dyes. The handling and storage of Acetanilide in large quantities require adherence to safety protocols to mitigate the risks associated with its toxicological properties. Overall, the production and procurement of Acetanilide involve careful synthesis and handling to ensure the quality and safety of the compound for its intended uses.
⚠️ Safety Considerations
Safety Considerations for Acetanilide:
Acetanilide is a chemical compound that should be handled with care due to its potential health hazards. It is important to wear appropriate personal protective equipment, such as gloves and goggles, when working with this substance. Additionally, acetanilide should be stored in a cool, dry place away from heat and sources of ignition to prevent the risk of fire or explosion.
Pharmacology of Acetanilide:
Acetanilide is an analgesic and antipyretic drug that inhibits the production of prostaglandins, which are involved in the body’s inflammatory response. By blocking the synthesis of prostaglandins, acetanilide helps to reduce pain and fever. It is commonly used in the treatment of mild to moderate pain and fever, although its use has declined due to safety concerns.
Hazard Statements for Acetanilide:
Acetanilide is classified as harmful if swallowed, inhaled, or in contact with skin. It may cause skin irritation and serious eye damage. Prolonged or repeated exposure to acetanilide may cause damage to organs, particularly the liver and kidneys. It is important to handle this substance with caution and follow appropriate safety protocols to minimize the risk of harm.
Precautionary Statements for Acetanilide:
When working with acetanilide, it is important to wear protective clothing, gloves, and safety goggles to avoid skin contact and inhalation. In case of contact with the skin or eyes, rinse immediately with plenty of water and seek medical advice. Acetanilide should be used in a well-ventilated area to prevent exposure to vapors. It is also essential to wash hands thoroughly after handling this compound and to dispose of any contaminated materials properly.
🔬 Potential Research Directions
Potential research directions for Acetanilide could involve further exploring its pharmaceutical applications, particularly in the development of new analgesic drugs. Studies may also focus on understanding the mechanisms of action and potential side effects of Acetanilide in order to optimize its therapeutic use. Additionally, research could investigate the environmental impact of Acetanilide and explore novel methods for its synthesis that are more sustainable and efficient.
🧪 Related Compounds
One similar compound to Acetanilide based upon molecular structure is Phenacetin. Like Acetanilide, Phenacetin contains an acetamido group attached to a benzene ring. The main difference between the two compounds is that Phenacetin has an ethoxy group attached to the benzene ring, whereas Acetanilide has a methyl group. Phenacetin is often used as a pain reliever and fever reducer.
Another compound with a similar molecular structure to Acetanilide is Paracetamol. Paracetamol, also known as acetaminophen, consists of an acetamido group attached to a benzene ring but lacks the methyl group present in Acetanilide. Paracetamol is widely used as a common over-the-counter pain reliever and fever reducer. Its chemical structure closely resembles that of Acetanilide, making it a comparable compound in terms of molecular structure.