2-Azacyclooctanone, also known as pyrrolidin-2-one, is a chemical compound with various industrial and commercial applications. It is widely used as a building block in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. Its unique molecular structure allows for a wide range of chemical reactions, making it a versatile and valuable compound in the field of organic chemistry. Its relevance to everyday life lies in its contribution to the development of new drugs, pesticides, and other materials that impact various aspects of human health and well-being.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
2-Azacyclooctanone, also known as pyrrolidone, finds commercial and industrial applications as a solvent in the manufacturing of polymers, plastics, and pharmaceuticals. It is commonly used in the production of polyvinylpyrrolidone (PVP), a polymer found in a variety of products such as adhesives, coatings, and cosmetics.
In the drug and medication industry, 2-Azacyclooctanone is used as a pharmaceutical intermediate in the synthesis of various drugs and medications. It is particularly valuable in the production of psychiatric drugs, such as antipsychotics and antidepressants, due to its ability to cross the blood-brain barrier and interact with the central nervous system.
Additionally, 2-Azacyclooctanone has shown promise in the field of drug delivery systems. It has been used to encapsulate and deliver active pharmaceutical ingredients, enhancing their solubility, stability, and bioavailability. This makes it a valuable compound in the development of novel drug formulations with improved therapeutic effects.
⚗️ Chemical & Physical Properties
2-Azacyclooctanone is a white crystalline solid with a faint ammonia-like odor. It typically appears as small, needle-like crystals and has a somewhat bitter taste. Its odor can be detected at low concentrations, making it easily distinguishable in laboratory settings.
The molar mass of 2-Azacyclooctanone is approximately 113.16 g/mol, and its density is around 1.09 g/cm³. This places it in the range of common food items such as table sugar (180.16 g/mol, 1.59 g/cm³) and flour (30.03 g/mol, 0.52 g/cm³), indicating a moderate molar mass and density compared to typical household ingredients.
2-Azacyclooctanone has a melting point of about 75-80°C and a boiling point of around 190-195°C. This places it in the range of common food items like butter (melting point of 30-35°C) and water (boiling point of 100°C), indicating a relatively high melting and boiling point compared to everyday cooking components.
2-Azacyclooctanone is sparingly soluble in water and exhibits low viscosity. This contrasts with common food items like salt (high solubility in water) and honey (high viscosity), suggesting that 2-Azacyclooctanone has limited solubility and low viscosity in comparison to various household staples.
🏭 Production & Procurement
2-Azacyclooctanone, commonly known as 2-ACO, is primarily produced synthetically in laboratory settings. The production process typically involves the condensation of cyclohexanone with hydroxylamine hydrochloride to form the desired compound.
To procure 2-Azacyclooctanone, one must typically turn to specialized chemical suppliers or manufacturers. This compound is not typically found in common consumer products or readily available in local stores. It is often transported in bulk quantities via specialized chemical transportation methods to ensure safety and compliance with regulations.
In some cases, 2-Azacyclooctanone may be available through online chemical suppliers or wholesalers. Proper handling and storage guidelines must be followed when procuring and transporting this compound due to its potential reactivity and hazardous nature. It is essential to work with reputable suppliers to ensure the quality and safety of the product.
⚠️ Safety Considerations
Safety considerations for 2-Azacyclooctanone, also known as oxacyclooctan-2-one or caprolactam, must be taken into account due to its potential hazards. This compound is a strong irritant to the skin, eyes, and respiratory tract. Ingestion or inhalation of 2-Azacyclooctanone can lead to irritation, nausea, and vomiting. Prolonged or repeated exposure may cause sensitization or allergic reactions. Therefore, proper personal protective equipment, such as gloves, goggles, and respiratory protection, should be worn when handling this chemical. Additionally, 2-Azacyclooctanone should be used in a well-ventilated area to minimize exposure to vapors.
The hazard statements for 2-Azacyclooctanone include “Causes skin irritation,” “Causes serious eye irritation,” and “May cause respiratory irritation.” These statements indicate the potential risks associated with exposure to this compound. Skin contact with 2-Azacyclooctanone can result in irritation and inflammation, while contact with the eyes may lead to redness, tearing, and pain. Inhalation of vapors or mists of this chemical can cause irritation to the respiratory tract, leading to symptoms such as coughing, shortness of breath, and sore throat. It is important to handle 2-Azacyclooctanone with caution and take appropriate safety measures to minimize the risks of exposure.
Precautionary statements for 2-Azacyclooctanone include “Wear protective gloves/protective clothing/eye protection/face protection,” “IF ON SKIN: Wash with plenty of soap and water,” and “IF IN EYES: Rinse cautiously with water for several minutes.” These statements emphasize the importance of using personal protective equipment, such as gloves, protective clothing, goggles, and face protection, when handling this chemical. In case of skin contact, the affected area should be washed thoroughly with soap and water. If 2-Azacyclooctanone comes into contact with the eyes, they should be rinsed with water for several minutes to remove the chemical. It is essential to follow these precautionary measures to ensure safe handling and minimize the potential risks associated with 2-Azacyclooctanone.
🔬 Potential Research Directions
One potential research direction for 2-Azacyclooctanone pertains to its use as a building block in drug discovery. Researchers may investigate the synthesis of novel compounds containing 2-Azacyclooctanone as a core structure to explore its potential pharmacological activities.
Another research avenue could involve the study of the reactivity of 2-Azacyclooctanone in various chemical transformations. Understanding the chemical properties of this compound can provide valuable insights into its potential applications in organic synthesis and material science.Researchers may also explore the biological activities of 2-Azacyclooctanone derivatives to evaluate their potential as therapeutic agents for various medical conditions.
Furthermore, investigations into the potential environmental and toxicological effects of 2-Azacyclooctanone and its derivatives could provide valuable information for assessing their safety and potential risks to human health and the environment. Additionally, research on the bioavailability and metabolism of 2-Azacyclooctanone in living organisms can contribute to a better understanding of its biological effects and potential uses.
🧪 Related Compounds
One similar compound to 2-Azacyclooctanone based upon molecular structure is 2-Azabicyclo[2.2.2]octan-2-one. This compound also contains a cyclic amine group with an oxygen atom in the ring structure. The presence of the oxygen atom in the ring imparts similar reactivity and characteristics to 2-Azacyclooctanone.
Another compound that shares a similar molecular structure to 2-Azacyclooctanone is 2-Azabicyclo[3.2.1]octan-2-one. This compound also contains a cyclic amine group with a nitrogen atom in the ring structure. The unique arrangement of atoms in the ring structure of this compound leads to similar chemical properties and behavior as 2-Azacyclooctanone.
A third compound with a molecular structure akin to 2-Azacyclooctanone is 2-Azabicyclo[3.1.0]hexan-2-one. Like 2-Azacyclooctanone, this compound features a cyclic amine group with a nitrogen atom in the ring structure. The arrangement of atoms in the ring structure of this compound contributes to its resemblance in reactivity and properties to 2-Azacyclooctanone.
