3-Aminoquinoline is a chemical compound that plays a significant role in everyday life, particularly in the field of medicine. It is commonly used in the synthesis of various pharmaceuticals, including antimalarial drugs such as chloroquine. These drugs are essential for treating and preventing malaria, a disease that affects millions of people worldwide. Additionally, 3-Aminoquinoline is also used in the manufacturing of dyes, fluorescence probes, and other chemical products. Its versatile nature and widespread applications make it a crucial ingredient in various industries that contribute to our daily lives.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
3-Aminoquinoline, a compound with a functional amino group attached to a quinoline ring, has various commercial and industrial applications. It is used in the production of dyes and pigments, particularly as a precursor for the synthesis of fluorescent dyes. Additionally, 3-Aminoquinoline is utilized in the manufacture of pharmaceuticals and agrochemicals due to its versatile chemical properties.
In the realm of drug and medication applications, 3-Aminoquinoline has been extensively studied for its antimalarial properties. Chloroquine, a derivative of 3-Aminoquinoline, is a well-known antimalarial drug that has been used for decades. The compound’s ability to inhibit the growth of the malaria parasite has made it a crucial component in the fight against this deadly disease.
Furthermore, 3-Aminoquinoline derivatives have shown promise in the treatment of other diseases, such as cancer and autoimmune disorders. Research has demonstrated their potential as anti-cancer agents by targeting specific pathways in cancer cells. In autoimmune diseases, 3-Aminoquinoline compounds have been studied for their immunomodulatory effects, offering new avenues for therapeutic interventions.
⚗️ Chemical & Physical Properties
3-Aminoquinoline is a crystalline solid with a yellow coloration and a slight odor. Its appearance is characteristic of aromatic compounds, with a defined structure that reflects its chemical composition.
The molar mass of 3-Aminoquinoline is approximately 144.17 g/mol, with a density of about 1.09 g/cm³. In comparison to common food items, 3-Aminoquinoline has a lower molar mass and a higher density, reflecting its chemical structure and properties.
The melting point of 3-Aminoquinoline is around 45-48°C, while its boiling point is approximately 257-259°C. These values are higher than those of common food items, indicating the stability and structure of 3-Aminoquinoline as a chemical compound.
3-Aminoquinoline is sparingly soluble in water and exhibits moderate viscosity. Compared to common food items, it has lower solubility in water and higher viscosity, characteristics that are typical of organic compounds with aromatic structures.
🏭 Production & Procurement
3-Aminoquinoline is typically produced through a synthetic process involving the reaction of aniline with acrolein to form 3-aminocrotonic acid, which is then cyclized to yield 3-Aminoquinoline. This reaction sequence involves multiple steps and requires careful control of reaction conditions to ensure high yield and purity of the final product.
The procurement of 3-Aminoquinoline can be carried out through various chemical suppliers and manufacturers who specialize in providing fine chemicals and intermediates to research and industrial laboratories. Due to its sensitive nature, 3-Aminoquinoline is often supplied in sealed containers to prevent moisture or air exposure, which can degrade the compound. Transportation of 3-Aminoquinoline should be done in compliance with regulations governing the transportation of hazardous chemicals, ensuring proper labeling and handling procedures are followed.
When procuring 3-Aminoquinoline for research or industrial use, it is crucial to verify the quality and purity of the product through analytical testing methods such as HPLC or GC. The storage of 3-Aminoquinoline should be done in a cool, dry place away from direct sunlight to prevent degradation. Proper safety precautions should be taken when handling 3-Aminoquinoline, including the use of personal protective equipment and adherence to safe handling practices to minimize the risk of exposure.
⚠️ Safety Considerations
Safety considerations for 3-Aminoquinoline include its potential to cause skin and eye irritation upon contact. It is also harmful if swallowed or inhaled, with potential effects on the respiratory system. Proper personal protective equipment should be worn, such as gloves and goggles, when handling this chemical to minimize exposure.
Hazard statements for 3-Aminoquinoline indicate that it may cause skin and eye irritation upon contact. It is also harmful if swallowed or inhaled, potentially causing damage to the respiratory system. Precautions should be taken to prevent exposure and ensure proper handling of this substance.
Precautionary statements for 3-Aminoquinoline include wearing protective gloves and eye protection when handling. Avoid breathing in dust or fumes, and wash hands thoroughly after handling. Store in a well-ventilated area and keep away from sources of ignition to prevent potential hazards.
🔬 Potential Research Directions
One potential research direction for 3-Aminoquinoline is its use as a building block in the synthesis of new pharmaceutical compounds. By exploring the diverse chemical reactivity of this compound, researchers can create novel drug candidates with potentially improved pharmacological properties.
Another area of interest lies in investigating the biological activities of 3-Aminoquinoline derivatives. Research can focus on studying their interactions with biological targets, such as enzymes or receptors, to elucidate their mode of action. This could lead to the development of new therapeutic agents for treating various diseases.
Furthermore, the potential anti-malarial properties of 3-Aminoquinoline derivatives can be explored through pharmacological studies. By assessing their efficacy against Plasmodium parasites, researchers can contribute to the development of improved anti-malarial treatments. This research direction could help address the growing problem of drug resistance in malaria.
🧪 Related Compounds
One similar compound to 3-Aminoquinoline is 8-Aminoquinoline, which shares the same basic quinoline structure but differs in the position of the amino group. This compound is also commonly used in various chemical reactions and pharmaceutical applications due to its similar chemical properties to 3-Aminoquinoline. The only difference being the positioning of the amino group on the quinoline ring.
Another related compound is 5-Aminoquinoline, which has the amino group attached to a different carbon atom on the quinoline ring compared to 3-Aminoquinoline. Despite this small structural difference, 5-Aminoquinoline exhibits similar chemical reactivity and biological activity to 3-Aminoquinoline in many cases. This compound is also widely used in organic synthesis and pharmaceutical research due to its close resemblance to 3-Aminoquinoline.
2-Aminoquinoline is another compound closely related to 3-Aminoquinoline, differing only in the position of the amino group on the quinoline ring. Like its counterparts, 2-Aminoquinoline is utilized in various chemical reactions and pharmaceutical applications due to its comparable chemical properties. This compound serves as another valuable tool in organic synthesis and drug discovery efforts, showcasing the versatility of quinoline-based compounds in the field of chemistry.
