2,6-Di-tert-butyl-4-methoxyphenol, commonly known as BHT, is a chemical compound widely used as an antioxidant in various industries, including food and cosmetics. This compound helps prevent oxidation and rancidity in food products, extending their shelf life. In addition, BHT is also used in cosmetic products to prevent degradation and maintain the quality of the product. Its relevance to everyday life lies in its role in preserving the freshness and quality of food and cosmetic products consumed by the general public.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
2,6-DI-Tert-butyl-4-methoxyphenol, also known as BHT, is commonly used as an antioxidant in commercial and industrial applications. It is often added to food products, such as oils and fats, to prevent them from rancidity and extend their shelf life. In addition, BHT is also used in the manufacturing of cosmetics, pharmaceuticals, and rubber products.
In the field of drug and medication applications, 2,6-DI-Tert-butyl-4-methoxyphenol is utilized as an antioxidant in pharmaceutical formulations. It helps to stabilize medications and prevent degradation, ensuring their potency and effectiveness over time. BHT is commonly used in the production of vitamin supplements, as well as in various topical creams and ointments.
Overall, 2,6-DI-Tert-butyl-4-methoxyphenol plays a crucial role in various commercial and industrial settings, as well as in the pharmaceutical industry. Its antioxidant properties make it a valuable ingredient in a wide range of products, helping to maintain their quality and stability.
⚗️ Chemical & Physical Properties
2,6-DI-Tert-butyl-4-methoxyphenol appears as a white crystalline solid with a faint odor. It is commonly used as an antioxidant in various industrial applications.
With a molar mass of 224.31 g/mol and a density of 1.017 g/cm³, 2,6-DI-Tert-butyl-4-methoxyphenol is heavier than common food items such as water (18.015 g/mol) and sugar (342.3 g/mol) but lighter than oil (about 900 g/mol).
The compound has a melting point of 113-115°C and a boiling point of 162-164°C. In comparison, common food items like butter (melting point around 32°C) and water (boiling point at 100°C) have significantly lower melting and boiling points.
2,6-DI-Tert-butyl-4-methoxyphenol is sparingly soluble in water and has a low viscosity. This is in contrast to common food items like salt and sugar, which are highly soluble in water, and honey and syrup, which have high viscosity.
🏭 Production & Procurement
2,6-DI-Tert-butyl-4-methoxyphenol, also known as BHT-4, is typically produced through a multi-step synthesis process. The first step involves the reaction of 2,6-di-tert-butylphenol with methanol and hydrochloric acid to form the corresponding methyl ether. Subsequently, the methyl ether is hydrogenated over a palladium catalyst to yield 2,6-DI-Tert-butyl-4-methoxyphenol.
2,6-DI-Tert-butyl-4-methoxyphenol can be procured from chemical suppliers specializing in antioxidants and preservatives. It is commonly available in bulk quantities in the form of white crystalline powder or granules. The compound can be transported in sealed containers to prevent exposure to moisture and ensure its stability during transit.
When procuring 2,6-DI-Tert-butyl-4-methoxyphenol, it is essential to adhere to handling and storage guidelines to maintain its efficacy and prolong its shelf life. Proper labeling, documentation, and compliance with safety regulations are necessary to ensure the safe transport and storage of the compound. Additionally, it is recommended to source the compound from reputable suppliers to guarantee its purity and quality for various industrial applications.
⚠️ Safety Considerations
Safety considerations for 2,6-DI-Tert-butyl-4-methoxyphenol should be taken seriously due to its potential hazards. This chemical should be handled with care to avoid skin and eye contact, inhalation, or ingestion. Proper personal protective equipment such as gloves, goggles, and a lab coat should be worn when working with this substance to minimize the risk of exposure.
Additionally, precautions should be taken when storing 2,6-DI-Tert-butyl-4-methoxyphenol to prevent any accidents or spills. The chemical should be kept in a tightly sealed container in a well-ventilated area away from sources of ignition. It is important to follow all recommended storage guidelines provided by the manufacturer to ensure the safety of the laboratory and those working with the substance.
Hazard statements for 2,6-DI-Tert-butyl-4-methoxyphenol include the potential for causing skin and eye irritation, as well as respiratory irritation if inhaled. This chemical may also be harmful if swallowed, and could cause damage to organs with prolonged or repeated exposure. It is important to handle 2,6-DI-Tert-butyl-4-methoxyphenol with caution and to follow all recommended safety protocols to minimize the risk of adverse health effects.
Precautionary statements for 2,6-DI-Tert-butyl-4-methoxyphenol include the need to wear appropriate personal protective equipment when working with the substance, such as gloves, goggles, and a lab coat. It is important to avoid skin and eye contact, as well as inhalation or ingestion of the chemical. In case of accidental exposure, it is recommended to seek medical attention immediately and to have the Safety Data Sheet readily available for reference.
🔬 Potential Research Directions
One potential research direction for 2,6-DI-Tert-butyl-4-methoxyphenol is its antioxidant properties. Studies could focus on investigating the compound’s ability to prevent oxidative damage and its potential use in various industries such as food preservation and cosmetics. Additionally, research could explore the mechanism of action by which 2,6-DI-Tert-butyl-4-methoxyphenol scavenges free radicals and protects against oxidative stress.
Another potential research direction for 2,6-DI-Tert-butyl-4-methoxyphenol is its potential applications in pharmaceuticals. Investigations could be conducted to assess the compound’s efficacy in treating conditions associated with oxidative stress, such as neurodegenerative diseases and cardiovascular disorders. Furthermore, research could delve into the pharmacokinetics and pharmacodynamics of 2,6-DI-Tert-butyl-4-methoxyphenol to determine its safety profile and optimal dosage for therapeutic use.
🧪 Related Compounds
One compound that is structurally similar to 2,6-DI-Tert-butyl-4-methoxyphenol is 2,6-Di-Tert-butyl-4-ethylphenol. This compound shares the same basic structure of a phenol ring with two bulky Tert-butyl groups attached at the 2 and 6 positions. However, in this compound, the methoxy group is replaced with an ethyl group, leading to a slightly different chemical and physical properties.
Another compound with similar structure is 2,6-Di-Tert-butyl-4-hydroxyphenylacetic acid. In this compound, the methoxy group is replaced with a carboxylic acid group, resulting in an acidic compound. The Tert-butyl groups still provide steric hindrance, affecting the compound’s reactivity and solubility properties, similar to 2,6-DI-Tert-butyl-4-methoxyphenol.
A third structurally similar compound is 2,6-Di-Tert-butyl-4-chlorophenol. In this compound, the methoxy group is replaced with a chlorine atom, altering the compound’s electronic properties. The Tert-butyl groups still provide steric hindrance, impacting the compound’s stability and reactivity, similar to 2,6-DI-Tert-butyl-4-methoxyphenol.
