2-Hydroxy-3-Methoxybenzaldehyde, commonly known as guaiacol, is a compound with a variety of practical applications in everyday life. It is often used as a flavoring agent in foods and beverages, imparting a smoky or medicinal taste. Guaiacol is also utilized in the fragrance industry, adding a distinct aroma to perfumes and colognes. Additionally, this compound has antiseptic properties and is an ingredient in some over-the-counter medications. Overall, 2-Hydroxy-3-Methoxybenzaldehyde plays a significant role in enhancing the sensory experience and promoting wellness in our daily lives.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
2-Hydroxy-3-Methoxybenzaldehyde, also known as Vanillin Salicylaldehyde, has various commercial and industrial applications. Its pleasant vanilla-like aroma makes it a popular fragrance in perfumes, soaps, and detergents. Additionally, it is used as a flavoring agent in food and beverages due to its sweet, creamy taste.
In the pharmaceutical industry, 2-Hydroxy-3-Methoxybenzaldehyde is utilized for its antibacterial and anti-inflammatory properties. It is commonly incorporated into topical creams and ointments to treat skin conditions such as eczema and psoriasis. Moreover, its antioxidant properties make it a valuable ingredient in anti-aging skincare products.
In the field of drug development, 2-Hydroxy-3-Methoxybenzaldehyde is being studied for its potential therapeutic effects in treating neurological disorders such as Alzheimer’s disease. Its ability to inhibit the formation of amyloid plaques in the brain has sparked interest in its use as a neuroprotective agent. Further research is ongoing to explore its full range of medicinal applications.
⚗️ Chemical & Physical Properties
2-Hydroxy-3-Methoxybenzaldehyde is a white crystalline solid with a sweet, floral odor.
The molar mass of 2-Hydroxy-3-Methoxybenzaldehyde is 166.16 g/mol, and its density is 1.18 g/cm3. This compound has a similar molar mass to glucose and a lower density compared to olive oil.
2-Hydroxy-3-Methoxybenzaldehyde has a melting point of 61-63°C and a boiling point of 288-289°C. These values are higher than those of water and lower than those of butter.
This compound is sparingly soluble in water and has a low viscosity. Its solubility is comparable to that of sucrose, and its viscosity is lower than that of honey.
🏭 Production & Procurement
2-Hydroxy-3-Methoxybenzaldehyde, also known as guaiacol, is produced through the methylation of 3-hydroxy-4-methoxybenzaldehyde using dimethyl sulfate in the presence of potassium hydroxide. This process facilitates the introduction of a methoxy group to the aldehyde functional group, resulting in the formation of 2-Hydroxy-3-Methoxybenzaldehyde.
The procurement of 2-Hydroxy-3-Methoxybenzaldehyde involves sourcing the precursor chemicals, including 3-hydroxy-4-methoxybenzaldehyde, dimethyl sulfate, and potassium hydroxide. These chemicals can be obtained through chemical suppliers and manufacturers, ensuring that they meet the required purity criteria for the production process. Once the synthesis is complete, the 2-Hydroxy-3-Methoxybenzaldehyde product can be transported in sealed containers to avoid contamination and degradation during transit.
Transporting 2-Hydroxy-3-Methoxybenzaldehyde requires adherence to regulations governing the handling and transportation of hazardous chemicals. Proper labeling and packaging are essential to ensure the safety of personnel involved in handling the product. Additionally, transport containers must be compatible with the chemical properties of 2-Hydroxy-3-Methoxybenzaldehyde to prevent leaks or spills during transit.
⚠️ Safety Considerations
Safety considerations for 2-Hydroxy-3-Methoxybenzaldehyde should be taken seriously due to its hazardous properties. This compound is a skin irritant and can cause irritation to the eyes and respiratory tract upon contact or inhalation. It is also flammable and should be handled with appropriate safety measures to prevent accidents or fires. Additionally, exposure to 2-Hydroxy-3-Methoxybenzaldehyde should be avoided by pregnant women or individuals with respiratory conditions due to its potential harmful effects.
Hazard statements for 2-Hydroxy-3-Methoxybenzaldehyde include: harmful if swallowed, causes skin irritation, causes serious eye irritation, and may cause respiratory irritation. These hazard statements indicate the potential risks associated with exposure to this compound and emphasize the importance of following safety protocols when handling it. Proper personal protective equipment should be worn to minimize contact with the skin, eyes, and respiratory system.
Precautionary statements for 2-Hydroxy-3-Methoxybenzaldehyde include: avoid breathing dust/fume/gas/mist/vapors/spray, wear protective gloves/protective clothing/eye protection/face protection, and wash hands thoroughly after handling. These precautionary statements provide guidance on how to safely handle and use 2-Hydroxy-3-Methoxybenzaldehyde to reduce the risk of exposure and minimize potential harm. Following these precautions is essential to protect oneself and others from the hazardous effects of this compound.
🔬 Potential Research Directions
One potential research direction for 2-Hydroxy-3-Methoxybenzaldehyde involves its use as a precursor in the synthesis of various biologically active compounds. By exploring different reaction pathways and optimizing synthetic methods, researchers can potentially access novel derivatives with improved pharmacological properties.
Another avenue of research for 2-Hydroxy-3-Methoxybenzaldehyde lies in its potential applications in the field of materials science. By studying its chemical properties and reactivity, researchers can investigate its potential as a building block for the design and synthesis of new materials with desirable properties, such as improved thermal stability or enhanced electrical conductivity.
Furthermore, 2-Hydroxy-3-Methoxybenzaldehyde may also be of interest in the field of organic chemistry for its role as a versatile building block in the synthesis of complex natural products and pharmaceuticals. By exploring different functional group transformations and exploring new synthetic methodologies, researchers can potentially access structurally diverse molecules with interesting biological activities.
🧪 Related Compounds
2-Hydroxy-3-Methoxybenzaldehyde, also known as Vanillin, is a compound with a molecular structure very similar to other aromatic aldehydes. One such compound is 2-Hydroxy-5-Methoxybenzaldehyde, which also possesses a hydroxyl group and a methoxy group attached to a benzene ring. This compound is commonly used in the flavor and fragrance industry as a food additive and flavoring agent.
Another similar compound to 2-Hydroxy-3-Methoxybenzaldehyde is 2-Hydroxy-4-Methoxybenzaldehyde, also known as Vanillic aldehyde. This compound differs from Vanillin by the position of the methoxy group on the benzene ring. Vanillic aldehyde is often used in the production of pharmaceuticals, as well as in the synthesis of various aromatic compounds.
2-Hydroxy-3-Methoxybenzaldehyde is also structurally similar to 3-Hydroxy-4-Methoxybenzaldehyde, which is commonly referred to as Protocatechuic aldehyde. This compound is widely used in the pharmaceutical industry due to its antioxidant properties and potential health benefits. Protocatechuic aldehyde is also a key intermediate in the synthesis of various bioactive molecules.
