2-Methyl-4-nitroaniline is a chemical compound that is used in the production of dyes, pharmaceuticals, and agricultural chemicals. Despite its technical nature, this compound plays a crucial role in everyday life through its contribution to the creation of colored products, medicines, and pesticides. The versatility of 2-Methyl-4-nitroaniline underscores its relevance in various industries and ultimately impacts consumers in their daily interactions with dyed goods, medications, and agricultural products.
Table of Contents:
Commercial Applications
Chemical & Physical Properties
Production & Procurement
Safety Considerations
Potential Research Directions
Related Compounds
Commercial Applications
Firstly, 2-Methyl-4-nitroaniline, also known as DAPSA, has various commercial and industrial applications. It is commonly used as a precursor in the production of dyes, pigments, and pharmaceuticals due to its chemical properties. Additionally, it is utilized in the synthesis of rubber chemicals and antioxidants for the manufacturing industry.
Moreover, 2-Methyl-4-nitroaniline has found applications in the production of certain drugs and medications. It is a key intermediate in the synthesis of pharmaceutical compounds such as anti-tuberculosis drugs and anti-inflammatory agents. Its ability to undergo diverse chemical reactions makes it a valuable building block in the pharmaceutical industry for creating novel drug molecules.
In conclusion, the diverse chemical properties of 2-Methyl-4-nitroaniline make it a versatile compound with significant commercial, industrial, and pharmaceutical applications. Its role as a precursor in the synthesis of dyes, pigments, pharmaceuticals, and rubber chemicals highlights its importance in various sectors. Additionally, its use in the production of drugs and medications demonstrates its potential in contributing to the development of new therapeutic agents.
Chemical & Physical Properties
2-Methyl-4-nitroaniline is a yellow crystalline solid with a faint odor. Its appearance is similar to powdered mustard and its odor can be described as slightly pungent.
The molar mass of 2-Methyl-4-nitroaniline is approximately 154.15 g/mol, with a density of 1.282 g/cm³. This places it in the same range as common food items such as sugar (molar mass around 342.3 g/mol) and flour (density around 0.5-0.6 g/cm³).
The melting point of 2-Methyl-4-nitroaniline is around 75-77°C, while its boiling point is approximately 276-277°C. These values are higher than most common food items, as sugar melts at around 160-186°C and water boils at 100°C.
2-Methyl-4-nitroaniline is sparingly soluble in water and has a low viscosity. This is in contrast to common food items like salt and sugar, which are highly soluble in water and have a higher viscosity.
Production & Procurement
2-Methyl-4-nitroaniline is produced through a multistep chemical synthesis process involving the reaction of 4-nitroaniline with acetic anhydride and concentrated sulfuric acid, followed by methylation with dimethyl sulfate. The resulting product is then purified through recrystallization to obtain 2-Methyl-4-nitroaniline in high purity.
2-Methyl-4-nitroaniline can be procured from chemical suppliers specializing in aromatic amines and related compounds. The compound is typically available in both bulk quantities for industrial use and smaller quantities for research and laboratory purposes. Transportation of 2-Methyl-4-nitroaniline is regulated due to its classification as a hazardous material, requiring adherence to strict safety guidelines and protocols.
Once procured, 2-Methyl-4-nitroaniline is typically transported in sealed containers or drums to prevent exposure to moisture and air, which can cause degradation of the compound. Proper labeling and documentation are required for the shipment of 2-Methyl-4-nitroaniline to ensure compliance with regulatory requirements. Storage of the compound should be in a cool, dry, and well-ventilated area away from sources of heat or ignition.
Safety Considerations
Safety considerations for 2-Methyl-4-nitroaniline, also known as MNMA, include its classification as a toxic substance that may cause harm if swallowed, inhaled, or in contact with skin. It is important to handle MNMA with care, wearing appropriate protective equipment such as gloves, goggles, and a lab coat. Additionally, this chemical should be stored in a well-ventilated area away from heat sources and incompatible materials to minimize the risk of accidents or exposure.
Hazard statements for 2-Methyl-4-nitroaniline include “Causes skin irritation,” “May cause an allergic skin reaction,” “Harmful if swallowed,” and “Toxic to aquatic life with long lasting effects.” These statements indicate the potential dangers associated with MNMA and emphasize the need for proper handling and disposal procedures to protect both human health and the environment from harm.
Precautionary statements for 2-Methyl-4-nitroaniline include “Wear protective gloves/protective clothing/eye protection/face protection,” “IF SWALLOWED: Rinse mouth. Do NOT induce vomiting,” “Dispose of contents/container to an approved waste disposal plant,” and “Avoid release to the environment.” These statements outline specific actions to take when working with MNMA to minimize the risk of exposure and ensure safe handling practices are followed to prevent accidents or environmental contamination.
Potential Research Directions
Potential research directions for 2-Methyl-4-nitroaniline include investigating its use as an intermediate in the synthesis of various organic compounds. This compound has shown potential for applications in the pharmaceutical, agricultural, and dye industries due to its unique chemical properties.
Furthermore, studies could be conducted to explore the toxicological effects of 2-Methyl-4-nitroaniline on both humans and the environment. Understanding the potential hazards associated with this compound is essential for ensuring its safe handling and use in industrial processes.
Additionally, research could focus on developing new methods for the synthesis of 2-Methyl-4-nitroaniline that are more efficient and environmentally friendly. Exploring alternative synthetic routes could lead to improved yields and reduced waste production, ultimately benefiting both the industry and the environment.
Related Compounds
One similar compound to 2-Methyl-4-nitroaniline is 2-Methyl-4-nitrophenol. This compound also contains a nitro group and a methyl group attached to a benzene ring, similar to 2-Methyl-4-nitroaniline. The primary difference is the presence of a phenolic hydroxyl group in 2-Methyl-4-nitrophenol, replacing the amino group in 2-Methyl-4-nitroaniline.
Another compound with a similar structure to 2-Methyl-4-nitroaniline is 2-Methyl-4-nitrobenzoic acid. This compound shares the nitro and methyl substituents on a benzene ring, but it also contains a carboxylic acid group. The presence of this functional group differentiates 2-Methyl-4-nitrobenzoic acid from 2-Methyl-4-nitroaniline.
2-Methyl-4-nitrotoluene is another compound closely related to 2-Methyl-4-nitroaniline. In this compound, a methyl group is attached to a benzene ring bearing a nitro group. The absence of an amino group distinguishes 2-Methyl-4-nitrotoluene from 2-Methyl-4-nitroaniline, highlighting the importance of functional groups in determining chemical properties.
