1-Methylpyrrole is a chemical compound that has importance in various areas of everyday life. It is a key building block in the production of pharmaceuticals, particularly in the synthesis of certain medications used to treat central nervous system disorders. Additionally, 1-Methylpyrrole is utilized in the manufacture of dyes, antioxidants, and fragrances. Its versatile properties make it a valuable component in numerous consumer products and industrial processes.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
1-Methylpyrrole has various commercial and industrial applications due to its properties. It is commonly used as a solvent in the manufacturing of pharmaceuticals, pesticides, and polymers. Additionally, 1-Methylpyrrole is utilized in the synthesis of organic compounds, such as dyes and fragrances.
In the realm of drug and medication applications, 1-Methylpyrrole plays a significant role. It is a key intermediate in the production of several pharmaceutical compounds, including antipsychotic drugs and antidepressants. Due to its versatility and stability, 1-Methylpyrrole is often favored in the pharmaceutical industry for its efficacy in drug synthesis.
Moreover, 1-Methylpyrrole is employed in the manufacturing of medicinally active compounds. It is used as a building block in the synthesis of anti-inflammatory drugs, anti-cancer agents, and other therapeutic compounds. The versatility of 1-Methylpyrrole in drug development makes it a valuable component in the pharmaceutical field.
⚗️ Chemical & Physical Properties
1-Methylpyrrole is a colorless liquid with a faint odor that is reminiscent of pyridine.
With a molar mass of approximately 81.11 g/mol and a density of about 0.974 g/cm³ at room temperature, 1-Methylpyrrole is lighter than common food items like sugar (molar mass: 342.30 g/mol, density: 1.59 g/cm³).
1-Methylpyrrole has a melting point of -27 °C and a boiling point of 111 °C, which are significantly lower than those of common food items such as butter (melting point: 32-35°C, boiling point: 150-200°C).
This compound is sparingly soluble in water but miscible in organic solvents, and it exhibits a low viscosity compared to common food items. For example, honey is highly soluble in water and has a higher viscosity than 1-Methylpyrrole.
🏭 Production & Procurement
1-Methylpyrrole is typically produced through a multistep process starting with the reaction of butanone with aniline to form an intermediate, which is subsequently cyclized to yield the desired product. This method of synthesis is commonly employed in industrial settings due to its efficiency and reproducibility.
The procurement of 1-Methylpyrrole can be achieved through various chemical suppliers and manufacturers who specialize in the production of organic compounds. Depending on the quantity needed, the compound can be obtained in bulk quantities or smaller amounts for research purposes. Transportation of 1-Methylpyrrole is typically done in sealed containers to prevent contamination and ensure its stability during transit.
For larger quantities, 1-Methylpyrrole can be shipped in drums or tankers, while smaller amounts may be packaged in bottles or vials for ease of handling. It is important to ensure that proper safety measures are taken during the handling and transport of 1-Methylpyrrole due to its potential hazards. Compliance with regulations regarding the transportation of hazardous chemicals is essential to prevent accidents and ensure the safe delivery of the compound to its intended destination.
⚠️ Safety Considerations
Safety considerations for 1-Methylpyrrole should be taken seriously due to its potential health hazards. 1-Methylpyrrole is a flammable liquid and vapor, and can cause skin and eye irritation upon contact. It can also cause respiratory irritation if inhaled, and ingestion may result in nausea, vomiting, and abdominal pain. Proper handling, storage, and disposal of 1-Methylpyrrole is essential to prevent accidents and exposure.
Hazard statements for 1-Methylpyrrole include the following: Highly flammable liquid and vapor (H225), Causes skin irritation (H315), Causes serious eye irritation (H319), May cause respiratory irritation (H335), and Harmful if swallowed (H302). These hazard statements highlight the potential dangers associated with 1-Methylpyrrole exposure, emphasizing the need for proper safety measures when handling this chemical.
Precautionary statements for 1-Methylpyrrole include wearing protective gloves, clothing, and eye protection (P280), keeping away from heat, sparks, and open flames (P210), avoiding breathing vapors, mists, or spray (P271), and washing hands thoroughly after handling (P264). Additionally, precautions such as storing in a well-ventilated place and keeping container tightly closed are recommended to minimize the risks associated with 1-Methylpyrrole. These precautionary statements serve as guidelines for safe handling practices to protect individuals from potential harm when working with this chemical.
🔬 Potential Research Directions
1-Methylpyrrole, a heterocyclic compound consisting of a pyrrole ring with a methyl group attached at the 1-position, has shown promise in various research areas. One potential research direction is the investigation of its pharmacological properties, as pyrrole derivatives have demonstrated biological activities such as antimicrobial and antitumor effects.
Furthermore, the synthesis and modification of 1-Methylpyrrole could be explored for the development of novel drug candidates. By altering its structural features, researchers may be able to enhance its efficacy and selectivity for specific biological targets. This could lead to the discovery of new therapeutic agents with improved pharmacokinetic profiles.
Additionally, the study of 1-Methylpyrrole as a building block in organic synthesis holds potential for the development of new methodologies and strategies in chemical synthesis. Its unique reactivity and versatility make it a valuable substrate for the construction of complex molecules, opening up avenues for the synthesis of compounds with diverse properties and applications.
🧪 Related Compounds
1-Methylindole is a compound similar to 1-Methylpyrrole in terms of molecular structure. Both compounds contain a five-membered aromatic ring with a nitrogen atom, but in 1-Methylindole, the nitrogen atom is attached to a carbon atom in the ring. This difference results in slightly different chemical properties and reactivity compared to 1-Methylpyrrole.
1-Methylimidazole is another compound with a similar molecular structure to 1-Methylpyrrole. Both compounds contain a five-membered aromatic ring with a nitrogen atom, but in 1-Methylimidazole, the nitrogen atom is part of a three-membered ring attached to the main ring. This difference in ring structure can affect the compound’s physical and chemical properties, leading to differences in reactivity and biological activity compared to 1-Methylpyrrole.
1-Methylbenzimidazole is a compound that shares structural similarities with 1-Methylpyrrole. Both compounds contain a five-membered aromatic ring with a nitrogen atom, but in 1-Methylbenzimidazole, the nitrogen atom is part of a fused ring system with a benzene ring. This fused ring structure can impact the compound’s stability and interactions with other molecules, leading to differences in chemical reactivity and biological activity compared to 1-Methylpyrrole.
