6-Amino-4-hydroxy-2-naphthalenesulfonic acid, also known as Congo red, is a dye that is commonly used in histology and cytology to stain tissues for microscopic examination. Its unique chemical properties allow it to bind to certain types of proteins and amyloid structures, making it a valuable tool in the detection and diagnosis of various diseases, such as Alzheimer’s and Parkinson’s. In everyday life, this compound plays a crucial role in medical research and diagnostics, helping to improve our understanding and treatment of serious health conditions. Its applications extend beyond the laboratory, as it is also used in the textile industry for fabric staining.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
6-Amino-4-hydroxy-2-naphthalenesulfonic acid, also known as AHNSA, finds several commercial and industrial applications. It is commonly used as a fluorescent dye in the textile industry for coloring fabrics and fibers. AHNSA is also utilized as a pH indicator in various chemical processes for its color-changing properties.
In the realm of drug and medication applications, 6-Amino-4-hydroxy-2-naphthalenesulfonic acid has shown promise as a precursor in the synthesis of pharmaceutical compounds. Its ability to form complex molecular structures makes it a valuable component in the production of certain medicines. Additionally, AHNSA has been researched for its potential use in drug delivery systems due to its biocompatibility and inert nature.
Overall, the multifaceted properties of 6-Amino-4-hydroxy-2-naphthalenesulfonic acid make it a versatile compound with wide-ranging applications in various industries. Its significance in both commercial and medicinal fields highlights its importance as a key chemical component in diverse manufacturing processes and pharmaceutical developments.
⚗️ Chemical & Physical Properties
6-Amino-4-hydroxy-2-naphthalenesulfonic acid appears as a white to light brown powder with no distinctive odor.
The molar mass of 6-Amino-4-hydroxy-2-naphthalenesulfonic acid is 311.30 g/mol, with a density of approximately 1.5 g/cm³. In comparison, common food items such as sugar (sucrose) have a molar mass of 342.3 g/mol and a density of 1.59 g/cm³.
The melting point of 6-Amino-4-hydroxy-2-naphthalenesulfonic acid is around 290°C, while the boiling point is approximately 710°C. These values exceed those of common food items like butter, which melts at approximately 32°C and boils at 350°C.
6-Amino-4-hydroxy-2-naphthalenesulfonic acid is highly soluble in water and exhibits a moderate viscosity. In contrast, common food items like salt are also soluble in water but do not typically have significant viscosity.
🏭 Production & Procurement
6-Amino-4-hydroxy-2-naphthalenesulfonic acid is typically produced through a series of chemical reactions starting with naphthalene. Naphthalene is first treated with sulfuric acid to form 2-naphthalenesulfonic acid, which is then further reacted with nitric acid to introduce an amino and hydroxyl group to produce the final compound.
The procurement of 6-Amino-4-hydroxy-2-naphthalenesulfonic acid is typically done through chemical suppliers who specialize in selling rare and specialized chemicals. It is usually available in crystalline or powder form, and can be purchased in varying quantities based on the needs of the buyer.
Once procured, 6-Amino-4-hydroxy-2-naphthalenesulfonic acid can be transported in sealed containers to prevent contamination. It is important to handle this compound with care as it can be sensitive to temperature, moisture, and light. Proper labeling and documentation should accompany the shipment to ensure safe handling and compliance with regulations.
⚠️ Safety Considerations
Safety considerations for 6-Amino-4-hydroxy-2-naphthalenesulfonic acid include its potential to cause skin and eye irritation upon contact. It is important to wear appropriate personal protective equipment, such as gloves and safety goggles, when handling this compound. Additionally, it is recommended to work with 6-Amino-4-hydroxy-2-naphthalenesulfonic acid in a well-ventilated area to minimize the risk of inhalation exposure.
Hazard statements for 6-Amino-4-hydroxy-2-naphthalenesulfonic acid include “Causes skin and eye irritation” and “May cause respiratory irritation.” These statements indicate the potential dangers associated with exposure to this compound. It is important to take necessary precautions to prevent contact with the skin, eyes, and respiratory system when working with 6-Amino-4-hydroxy-2-naphthalenesulfonic acid.
Precautionary statements for 6-Amino-4-hydroxy-2-naphthalenesulfonic acid include “Wear protective gloves/protective clothing/eye protection/face protection” and “IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do.” These statements emphasize the importance of using appropriate personal protective equipment and taking necessary steps to minimize the risk of exposure to 6-Amino-4-hydroxy-2-naphthalenesulfonic acid. It is crucial to follow these precautionary measures to ensure safe handling of this compound.
🔬 Potential Research Directions
One potential research direction for 6-Amino-4-hydroxy-2-naphthalenesulfonic acid involves investigating its effectiveness as a fluorescent labeling agent. Studies could explore its ability to selectively bind to specific targets in biological samples, serving as a tool for imaging and detecting proteins or other molecules of interest.
Another area of interest could be exploring the potential applications of 6-Amino-4-hydroxy-2-naphthalenesulfonic acid in the field of pharmaceuticals. Research could focus on its role as a precursor for the synthesis of novel drugs, or its potential as an active ingredient in medications targeting specific diseases or conditions.
Additionally, researchers may investigate the environmental impact of 6-Amino-4-hydroxy-2-naphthalenesulfonic acid and its derivatives. Studies could assess their persistence and potential for bioaccumulation in aquatic ecosystems, as well as their toxicity to various organisms. This research could provide valuable insights into the potential risks associated with the use and disposal of these compounds.
Furthermore, investigations into the chemical properties and reactivity of 6-Amino-4-hydroxy-2-naphthalenesulfonic acid could lead to the development of new synthetic methodologies or the optimization of existing reactions. By gaining a deeper understanding of its behavior in different conditions, researchers could unlock its full potential for a variety of applications in the fields of chemistry and materials science.
🧪 Related Compounds
One similar compound to 6-Amino-4-hydroxy-2-naphthalenesulfonic acid is 6-Amino-2-naphthalenesulfonic acid. This compound contains an amino group at the 6-position and a sulfonic acid group on the naphthalene ring. The lack of a hydroxyl group distinguishes it from 6-Amino-4-hydroxy-2-naphthalenesulfonic acid.
Another compound with a similar molecular structure is 6-Amino-4-nitro-2-naphthalenesulfonic acid. In this compound, the hydroxyl group in 6-Amino-4-hydroxy-2-naphthalenesulfonic acid is replaced with a nitro group. This substitution alters the chemical properties and reactivity of the compound.
Additionally, 6-Amino-4-chloro-2-naphthalenesulfonic acid is another compound with a comparable structure. Here, the hydroxyl group is replaced with a chlorine atom, resulting in a different set of chemical properties. This compound may exhibit different solubility, reactivity, and biological activity compared to 6-Amino-4-hydroxy-2-naphthalenesulfonic acid.
