2,2,2-Trichloro-1-phenylethyl acetate, commonly known as Clofedanol, is a chemical compound that has relevance in everyday life due to its use as an antitussive agent in cough and cold medications. This compound works by suppressing the cough reflex in the brain, providing relief from cough symptoms. As coughs are a common ailment experienced by individuals of all ages, the availability of medications containing Clofedanol plays a significant role in alleviating cough symptoms and improving overall quality of life. Additionally, the use of Clofedanol highlights the ongoing efforts in the pharmaceutical industry to develop effective treatments for common health issues.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
2,2,2-Trichloro-1-phenylethyl acetate, also known as ethyl trichloroacetate, finds commercial and industrial applications as a starting material in the synthesis of various pharmaceuticals, agrochemicals, and fragrances. This compound is commonly utilized in organic synthesis due to its ability to undergo various reactions such as esterification, alkylation, and acylation, making it a versatile building block for the creation of complex molecules.
In the realm of drug and medication applications, 2,2,2-Trichloro-1-phenylethyl acetate is used to synthesize active pharmaceutical ingredients (APIs) for a range of therapeutic purposes. Its chemical structure allows for modification and derivatization to create compounds with desired biological activities. The compound is often employed in the pharmaceutical industry to produce medications for treating various diseases and conditions.
Moreover, 2,2,2-Trichloro-1-phenylethyl acetate serves as a valuable intermediate in the production of pesticides, herbicides, and insecticides used in agriculture. Its incorporation into pesticide formulations enhances their effectiveness in controlling pests and diseases in crops. This compound plays a crucial role in the agricultural sector by contributing to the development of safer and more efficient crop protection products.
⚗️ Chemical & Physical Properties
2,2,2-Trichloro-1-phenylethyl acetate is a colorless liquid with a sweet, fruity odor. It is typically used as a flavoring agent or fragrance in various consumer products.
The molar mass of 2,2,2-Trichloro-1-phenylethyl acetate is 267.54 g/mol, and its density is 1.437 g/cm³. When compared to common food items, such as sugar (molar mass of 342.30 g/mol) and water (density of 1.00 g/cm³), 2,2,2-Trichloro-1-phenylethyl acetate has a lower molar mass and higher density.
2,2,2-Trichloro-1-phenylethyl acetate has a melting point of -25°C and a boiling point of 84°C. In contrast, common food items like sugar have a melting point of 186°C and a boiling point of 460°C. This indicates that 2,2,2-Trichloro-1-phenylethyl acetate has lower melting and boiling points compared to typical food items.
2,2,2-Trichloro-1-phenylethyl acetate is slightly soluble in water and has a low viscosity. When compared to common food items like salt (highly soluble in water) and honey (high viscosity), 2,2,2-Trichloro-1-phenylethyl acetate exhibits lower solubility and viscosity in aqueous solutions.
🏭 Production & Procurement
2,2,2-Trichloro-1-phenylethyl acetate is primarily produced through a multistep synthesis process involving the reaction of 1-phenylethanol with phosgene and thionyl chloride to form 2,2,2-trichloro-1-phenylethanone. This intermediate is then reacted with acetic acid in the presence of a base catalyst to yield the final product, 2,2,2-Trichloro-1-phenylethyl acetate.
To procure 2,2,2-Trichloro-1-phenylethyl acetate, one must typically turn to specialized chemical suppliers that carry the compound in its pure form. Due to its hazardous nature and potential for misuse, strict regulations govern the transportation of 2,2,2-Trichloro-1-phenylethyl acetate, requiring adherence to safety protocols and certification for handling hazardous materials.
Transportation of 2,2,2-Trichloro-1-phenylethyl acetate is typically carried out using specialized containers designed for hazardous chemicals, such as drums or tanks. Proper labeling and documentation are essential for ensuring compliance with regulations and safe handling during transit. It is recommended to consult with experts in chemical transportation to ensure the proper procedures are followed.
⚠️ Safety Considerations
Safety considerations for 2,2,2-Trichloro-1-phenylethyl acetate involve handling the compound with caution due to its potential hazards. It is important to use appropriate personal protective equipment such as gloves, goggles, and a lab coat when working with this chemical. Additionally, proper ventilation should be maintained to minimize exposure to the vapors.
It is essential to store 2,2,2-Trichloro-1-phenylethyl acetate in a cool, dry place away from incompatible substances such as strong acids or bases. The chemical should be kept in a tightly sealed container to prevent spills or leaks. In case of ingestion, inhalation, or skin contact, immediate medical attention should be sought, and the relevant safety data sheet should be consulted for further guidance.
The hazard statements for 2,2,2-Trichloro-1-phenylethyl acetate include “Causes skin irritation,” “May cause respiratory irritation,” and “Toxic to aquatic life with long-lasting effects.” These statements highlight the potential dangers associated with exposure to this compound and emphasize the need for proper handling and safety precautions to prevent adverse effects on human health and the environment.
Precautionary statements for 2,2,2-Trichloro-1-phenylethyl acetate advise wearing protective gloves, clothing, and eye protection when handling the chemical. It is recommended to wash hands thoroughly after handling and avoid release into the environment. In case of skin irritation or respiratory difficulties, it is advised to seek medical advice immediately and provide the doctor with the safety data sheet or product label for proper treatment guidance. Following these precautionary measures can help minimize the risks associated with working with 2,2,2-Trichloro-1-phenylethyl acetate.
🔬 Potential Research Directions
One potential area of research for 2,2,2-Trichloro-1-phenylethyl acetate involves exploring its potential applications in the field of organic synthesis due to its unique chemical structure and properties.
Another direction of research could involve studying the environmental impact of 2,2,2-Trichloro-1-phenylethyl acetate, particularly its persistence and potential for bioaccumulation in aquatic and terrestrial ecosystems.
Additionally, investigations into the pharmacological effects of 2,2,2-Trichloro-1-phenylethyl acetate may reveal its potential as a therapeutic agent or its toxicity profile in different biological systems.
🧪 Related Compounds
One similar compound to 2,2,2-Trichloro-1-phenylethyl acetate is 2,2,2-Trichloroethyl acetate. This compound also contains a trichloroethyl group, but instead of being attached to a phenyl ring, it is attached to an ethyl group. The presence of the acetate functional group remains the same, providing similar reactivity.
Another analogous compound is 2,2,2-Trichloro-1-phenylethyl propionate. In this compound, the acetate functional group is replaced with a propionate group, while still maintaining the trichloro-substituted phenylethyl moiety. The change in the ester group alters the chemical properties and reactivity of the compound.
A further related compound is 2,2,2-Trichloro-1-phenylethyl benzoate. This compound features a benzoate functional group instead of an acetate group, while preserving the trichloro-1-phenylethyl moiety. The change in the ester group introduces new structural and chemical characteristics to the molecule, impacting its potential applications and interactions.
