Estra-1,3,5(10)-triene-3,17-diol (17beta)-, 3-benzoate, also known as estradiol benzoate, is a synthetic form of the hormone estrogen. This compound is commonly used in hormone replacement therapy to treat symptoms of menopause, such as hot flashes and vaginal dryness. It can also be used to regulate the menstrual cycle and treat certain types of cancer. While estradiol benzoate may not directly impact the daily lives of most individuals, its importance lies in its ability to improve the quality of life for those experiencing hormonal imbalances or related health conditions.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
Estra-1,3,5(10)-triene-3,17-diol (17beta)-, 3-benzoate, commonly known as estradiol benzoate, is a synthetic form of the hormone estradiol. This compound is predominantly used in commercial and industrial applications as a hormone supplement in livestock, particularly in the dairy and meat industries. It is commonly used to regulate the reproductive cycle and improve growth rates in animals, leading to increased milk production and weight gain.
In addition to its commercial and industrial applications, estradiol benzoate also has important drug and medication applications. In the medical field, this compound is used as a hormone replacement therapy in women experiencing menopausal symptoms. It helps to alleviate symptoms such as hot flashes, vaginal dryness, and mood swings. Furthermore, estradiol benzoate is also used in certain hormone therapies for transgender individuals undergoing gender transition, helping to facilitate the development of secondary sexual characteristics.
The pharmaceutical industry also utilizes estradiol benzoate in the production of certain medications. It is commonly found in hormone replacement therapies, contraceptive pills, and treatments for breast and prostate cancers. The compound’s ability to mimic the effects of natural estrogen makes it a valuable component in various pharmaceutical products aimed at regulating hormonal imbalances and managing hormone-related conditions.
⚗️ Chemical & Physical Properties
Estra-1,3,5(10)-triene-3,17-diol (17beta)-, 3-benzoate is a white, crystalline solid with no distinct odor. Its appearance is similar to that of a typical powder substance found in a science laboratory.
With a molar mass of approximately 364.45 g/mol and a density of about 1.24 g/cm³, Estra-1,3,5(10)-triene-3,17-diol (17beta)-, 3-benzoate is heavier and denser than common food items like sugar and salt.
The compound has a melting point of around 158-162°C and a boiling point of approximately 520-525°C. These values are significantly higher than those of most common food items, such as butter and chocolate.
Estra-1,3,5(10)-triene-3,17-diol (17beta)-, 3-benzoate is sparingly soluble in water and exhibits a relatively low viscosity. This contrasts with many common food items that are highly soluble in water and have varying viscosities depending on their composition.
🏭 Production & Procurement
Estra-1,3,5(10)-triene-3,17-diol (17beta)-, 3-benzoate is typically produced through a series of chemical reactions involving esterification of 3-hydroxyestra-1,3,5(10)-triene with benzoic acid. This process is carried out under controlled conditions to ensure optimal yields and purity of the final product.
In order to procure Estra-1,3,5(10)-triene-3,17-diol (17beta)-, 3-benzoate, one must source the necessary starting materials (3-hydroxyestra-1,3,5(10)-triene and benzoic acid) from reputable chemical suppliers. Once the materials are obtained, they can be combined in the appropriate ratio and subjected to the esterification process, which typically requires the use of specialized equipment and expertise.
After the production process is complete, Estra-1,3,5(10)-triene-3,17-diol (17beta)-, 3-benzoate can be transported in sealed containers to prevent contamination or degradation of the compound. Proper labeling and documentation of the shipment are essential to ensure compliance with regulatory requirements and safe handling practices throughout the transportation process.
⚠️ Safety Considerations
Safety considerations for Estra-1,3,5(10)-triene-3,17-diol (17beta)-, 3-benzoate include the need for proper ventilation when handling the substance, as inhaling its vapors may result in respiratory irritation or other adverse effects. It is important to wear appropriate personal protective equipment, such as gloves and safety goggles, to prevent skin contact and eye irritation. Additionally, the substance should be stored in a cool, dry place away from sources of ignition to minimize the risk of fire or explosion.
The hazard statements for Estra-1,3,5(10)-triene-3,17-diol (17beta)-, 3-benzoate typically include warnings about its potential to cause skin and eye irritation, as well as respiratory effects if inhaled. It may also be harmful if swallowed or if it comes into contact with mucous membranes. Furthermore, the substance may have long-term health effects if exposure is prolonged or repeated, so caution is advised when handling and using it.
Precautionary statements for Estra-1,3,5(10)-triene-3,17-diol (17beta)-, 3-benzoate emphasize the importance of avoiding skin and eye contact by wearing appropriate protective clothing and equipment. It is recommended to wash hands thoroughly after handling the substance and to avoid eating, drinking, or smoking in the area where it is being used. In case of accidental exposure or ingestion, medical advice should be sought immediately, and the container label should be kept for reference.
🔬 Potential Research Directions
One potential research direction for Estra-1,3,5(10)-triene-3,17-diol (17beta)-, 3-benzoate could involve exploring its potential as a treatment for hormone-related conditions such as menopausal symptoms, osteoporosis, or breast cancer.
Additionally, researchers may be interested in investigating the pharmacokinetics and metabolism of this compound to better understand its bioavailability and potential interactions with other medications.
Furthermore, studies could be conducted to evaluate the potential side effects and safety profile of Estra-1,3,5(10)-triene-3,17-diol (17beta)-, 3-benzoate in order to assess its viability as a pharmaceutical agent for clinical use.
🧪 Related Compounds
One similar compound to Estra-1,3,5(10)-triene-3,17-diol (17beta)-, 3-benzoate is Estra-1,3,5(10)-triene-3,17-dione (17beta)-, 3-benzoate. This compound is a derivative of the original structure with the hydroxyl group at carbon 17 oxidized to a keto group. This change in functional group alters the biological activity of the compound, affecting its pharmaceutical properties.
Another similar compound is Estra-1,3,5(10)-triene-3-methanol, 17beta-benzoate. In this compound, the hydroxyl group at carbon 17 is replaced with a methyl group attached to a benzoate ester. This modification can impact the compound’s solubility, stability, and lipophilicity, influencing its pharmacokinetic and pharmacodynamic properties.
Additionally, Estra-1,3,5(10)-triene-3-benzoate-17-one is another related compound. In this structure, the hydroxyl group at carbon 17 is replaced by a ketone group attached to a benzoate ester. This alteration may result in changes in the compound’s reactivity, metabolism, and mode of action within biological systems. Such variations in structure can lead to differences in the compound’s efficacy and potential side effects when used in therapeutic applications.
