2-Thiobarbituric acid, while not a household name, holds significance in everyday life due to its role in various scientific fields. This compound is commonly utilized in chemistry labs as a reagent for detecting certain organic compounds, particularly those involving lipid oxidation and rancidity. Additionally, 2-Thiobarbituric acid has been studied for its potential health benefits, such as its antioxidant properties and neuroprotective effects. Overall, the relevance of this compound lies in its contribution to research and practical applications within the realms of chemistry, biology, and health sciences.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
2-Thiobarbituric acid, also known as 2-thioxothiazolidine-4-carboxylic acid, finds various commercial and industrial applications due to its unique chemical properties. It is commonly used as a reagent in chemical analysis, particularly in the detection and quantification of aldehydes and ketones in food products. Additionally, it is utilized in the synthesis of other organic compounds, such as pharmaceutical intermediates and agrochemicals.
In the field of drug development and medication, 2-Thiobarbituric acid plays a significant role as a precursor in the synthesis of barbiturates, a class of sedative-hypnotic drugs. Barbiturates are commonly used for their sedative and anticonvulsant properties in clinical settings. Furthermore, 2-Thiobarbituric acid derivatives have shown potential as inhibitors of various enzymes and receptors, making them promising candidates for drug discovery and development in the pharmaceutical industry.
Overall, 2-Thiobarbituric acid’s versatile nature and chemical reactivity make it a valuable compound in both commercial and industrial applications, ranging from chemical analysis and synthesis to drug development and medication. Its role as a key building block in the synthesis of barbiturates further underscores its importance in the pharmaceutical sector, highlighting its potential for contributing to the advancement of medical treatments and therapies.
⚗️ Chemical & Physical Properties
2-Thiobarbituric acid is a white crystalline solid with a characteristic odor. It is commonly used in analytical chemistry as a reagent for the detection of aldehydes and ketones due to its ability to form colored compounds upon reaction.
The molar mass of 2-Thiobarbituric acid is approximately 164.2 g/mol, with a density of around 1.75 g/cm^3. Compared to common food items, such as sugar or salt, 2-Thiobarbituric acid has a higher molar mass and density, making it more compact and heavier per unit volume.
2-Thiobarbituric acid has a melting point of around 182-183°C and a boiling point of approximately 360°C. Compared to common food items, which generally have lower melting and boiling points, 2-Thiobarbituric acid exhibits higher thermal stability under normal cooking conditions.
2-Thiobarbituric acid is sparingly soluble in water and exhibits relatively low viscosity. Compared to common food items like sugar or salt, which dissolve readily in water and have low viscosity, 2-Thiobarbituric acid has limited solubility and higher viscosity, making it less suitable for culinary applications.
🏭 Production & Procurement
2-Thiobarbituric acid is typically produced through the reaction of thiourea with diethyl malonate in the presence of base, followed by cyclization using a strong acid. This synthesis route allows for the formation of the desired 2-Thiobarbituric acid product with high yield and purity.
The procurement of 2-Thiobarbituric acid can be done through specialized chemical suppliers or custom synthesis services. The compound is typically available in both small-scale quantities for research purposes as well as bulk quantities for industrial applications. Transportation of 2-Thiobarbituric acid is typically done in sealed containers to prevent moisture or impurities from affecting the purity of the compound.
Care must be taken during the transportation of 2-Thiobarbituric acid to ensure that it is not exposed to extreme temperatures or physical damage. Proper labeling and handling instructions should be provided to those involved in the transportation process to ensure the safe delivery of the compound. It is important to adhere to all regulations and guidelines regarding the transportation of hazardous chemicals when dealing with 2-Thiobarbituric acid.
⚠️ Safety Considerations
Safety considerations for 2-Thiobarbituric acid include its potential to cause skin and eye irritation upon contact. It is important to handle this compound with caution, wearing appropriate personal protective equipment such as gloves and safety goggles. In case of ingestion or inhalation, seek medical attention immediately. Proper ventilation is essential when working with 2-Thiobarbituric acid to prevent exposure to harmful fumes.
Hazard statements for 2-Thiobarbituric acid include “Causes skin and eye irritation” and “May cause respiratory irritation.” These statements indicate the potential risks associated with handling this compound. It is important to be aware of these hazards and take appropriate precautions to minimize the likelihood of exposure.
Precautionary statements for 2-Thiobarbituric acid include “Wear protective gloves/eye protection” and “Avoid breathing dust/fume/gas/mist/vapors/spray.” These statements provide guidance on how to safely handle this compound to reduce the risk of adverse effects. It is important to follow these precautions to protect oneself from potential harm while working with 2-Thiobarbituric acid.
🔬 Potential Research Directions
One potential research direction for 2-Thiobarbituric acid involves its use as a building block in the synthesis of novel organic compounds. By exploring its reactivity towards various functional groups, researchers may discover new methods for creating complex molecular structures with potential applications in drug development or materials science.
Another promising avenue of research is the investigation of the biological activities of 2-Thiobarbituric acid and its derivatives. Studies have shown that this compound exhibits antioxidant properties and may have potential therapeutic effects in conditions related to oxidative stress. Further exploration of its pharmacological properties could lead to the development of new therapeutic agents with improved efficacy and reduced side effects.
🧪 Related Compounds
One similar compound to 2-Thiobarbituric acid is Thiobarituric acid. Thiobarbituric acid is a derivative of barbituric acid, where the oxygen atom at the C-2 position is replaced by a sulfur atom. This substitution results in a compound with similar chemical properties but with a sulfur atom instead of an oxygen atom in its structure.
Another similar compound to 2-Thiobarbituric acid is Thiouracil. Thiouracil is a sulfur analog of uracil, with the oxygen atom at the C-2 position replaced by a sulfur atom. This substitution gives Thiouracil similar properties to 2-Thiobarbituric acid, as both compounds contain a sulfur atom in their structures.
A third similar compound to 2-Thiobarbituric acid is Thiophene-2,5-dicarboxylic acid. Thiophene-2,5-dicarboxylic acid is a derivative of thiophene, where two carboxylic acid groups are attached at the 2 and 5 positions. While structurally different from 2-Thiobarbituric acid, Thiophene-2,5-dicarboxylic acid also contains a sulfur atom, giving it similar chemical properties to 2-Thiobarbituric acid.
