Cis-Caffeic acid, a naturally occurring compound found in various plant-based foods such as coffee, fruits, and vegetables, holds significance in everyday life due to its potential health benefits. Research suggests that cis-Caffeic acid possesses antioxidant and anti-inflammatory properties, which may contribute to reducing the risk of chronic diseases such as heart disease and certain types of cancer. Moreover, some studies have shown that cis-Caffeic acid could help in promoting skin health and improving cognitive function. Overall, the presence of cis-Caffeic acid in everyday diet highlights its potential role in supporting overall health and well-being.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
Cis-Caffeic acid, a hydroxycinnamic acid commonly found in plants, has various commercial and industrial applications. It is used as an antioxidant in food and cosmetic products, helping to prevent oxidation and extend shelf life. Additionally, cis-Caffeic acid is utilized in the production of pharmaceuticals, nutraceuticals, and herbal supplements due to its potential health benefits.
In the realm of drug and medication applications, cis-Caffeic acid has shown promise as a potential anti-inflammatory agent. It has been studied for its ability to reduce inflammation in the body and may be used in the development of new anti-inflammatory drugs. Furthermore, cis-Caffeic acid has been explored for its potential antiviral properties, showing inhibitory effects against certain viruses.
Research on cis-Caffeic acid’s medicinal properties also includes its potential use in cancer treatment. Studies have suggested that cis-Caffeic acid may have anticancer effects by inhibiting the growth of cancer cells and inducing apoptosis. This has sparked interest in utilizing cis-Caffeic acid in the development of cancer-fighting drugs and therapies.
⚗️ Chemical & Physical Properties
Cis-Caffeic acid is a crystalline solid that typically appears as white or light yellow in color. It has a slightly aromatic odor.
The molar mass of cis-Caffeic acid is approximately 180.16 g/mol, and its density is about 1.03 g/cm3. Compared to common food items, such as table sugar (sucrose) with a molar mass of 342.30 g/mol and a density of 1.59 g/cm3, cis-Caffeic acid has a lower molar mass and density.
The melting point of cis-Caffeic acid is around 223-225°C, while its boiling point is approximately 325-328°C. In comparison, common food items like butter have a melting point of around 32-35°C and a boiling point of about 150-200°C. Therefore, cis-Caffeic acid has significantly higher melting and boiling points.
Cis-Caffeic acid is sparingly soluble in water, but it is more soluble in organic solvents. It has a low viscosity, making it less viscous than substances like honey. Compared to common food items, cis-Caffeic acid exhibits lower solubility in water and lower viscosity.
🏭 Production & Procurement
cis-Caffeic acid is typically produced through the biosynthesis pathway in plants. It is derived from the amino acid phenylalanine, with the help of enzymes such as phenylalanine ammonia-lyase and cinnamic acid 4-hydroxylase. This process occurs in the cytoplasmic matrix of plant cells and culminates in the formation of cis-Caffeic acid.
Procurement of cis-Caffeic acid can be achieved through extraction from plant sources such as coffee beans, fruit skins, and certain vegetables. Once extracted, the compound can be purified through techniques like chromatography or crystallization. To ensure its stability during transport, cis-Caffeic acid is often stored in a cool, dry place and protected from light to prevent degradation.
Once procured, cis-Caffeic acid can be transported in various forms, such as as a powder, liquid, or encapsulated in tablets or capsules. It is important to ensure that the compound is packaged securely to prevent contamination or degradation during transit. Proper labeling and documentation of the compound’s origins and specifications are also crucial for regulatory compliance and quality control.
⚠️ Safety Considerations
Safety Considerations for cis-Caffeic acid:
cis-Caffeic acid is a naturally occurring compound found in various plant sources such as coffee, fruits, and vegetables. While cis-Caffeic acid is generally regarded as safe for consumption in small quantities through dietary sources, handling larger amounts of this compound may pose certain health risks. It is important to note that cis-Caffeic acid can cause skin irritation upon contact, and inhalation of its dust or fumes may result in respiratory irritation. To minimize the risk of exposure, proper protective measures such as gloves, goggles, and a well-ventilated workspace should be utilized when handling cis-Caffeic acid in its pure form.
Hazard Statements for cis-Caffeic acid:
The hazard statements for cis-Caffeic acid include irritation to the skin, eyes, and respiratory tract. Skin contact with cis-Caffeic acid may cause redness, itching, or burning sensations. Inhaling the dust or fumes of cis-Caffeic acid may result in coughing, difficulty breathing, or throat irritation. It is important to take necessary precautions to avoid direct contact with cis-Caffeic acid and to use proper protective equipment when handling this compound to prevent any adverse health effects.
Precautionary Statements for cis-Caffeic acid:
When working with cis-Caffeic acid, it is advised to wear protective gloves, goggles, and a face mask to prevent skin, eye, and respiratory irritation. It is important to handle cis-Caffeic acid in a well-ventilated area to minimize exposure to its dust or fumes. In case of skin contact, it is recommended to wash the affected area with soap and water, and seek medical attention if irritation persists. If cis-Caffeic acid is accidentally inhaled, move to a well-ventilated area and seek medical advice immediately. Proper storage and handling procedures should be followed to ensure the safe use of cis-Caffeic acid in laboratory settings.
🔬 Potential Research Directions
Potential research directions of cis-Caffeic acid include investigating its antioxidant properties and potential therapeutic effects in combating oxidative stress-related diseases. Studies could focus on elucidating its mechanisms of action at a molecular level, as well as exploring its interactions with other antioxidants. Additionally, research may delve into the potential synergistic effects of cis-Caffeic acid when combined with other bioactive compounds.
Furthermore, future studies could explore the bioavailability and pharmacokinetics of cis-Caffeic acid in order to optimize its delivery and efficacy. This could involve investigating different formulations or delivery systems to enhance its absorption and distribution in the body. Understanding the metabolism and excretion of cis-Caffeic acid is also crucial for designing effective therapeutic interventions.
Moreover, research could be directed towards exploring the potential neuroprotective effects of cis-Caffeic acid and its role in preventing neurodegenerative diseases. This could involve studying its effects on neuronal function, neuroinflammation, and oxidative damage in relevant disease models. Investigating the impact of cis-Caffeic acid on cognitive function and neurobehavioral outcomes could provide valuable insights into its therapeutic potential for neurological disorders.
🧪 Related Compounds
One similar compound to cis-Caffeic acid based upon molecular structure is trans-Caffeic acid. In trans-Caffeic acid, the hydroxyl groups are located on opposite sides of the double bond, resulting in a trans configuration. This compound also exhibits antioxidant properties and is found in various plant sources.
Another compound with a similar structure to cis-Caffeic acid is Ferulic acid. Ferulic acid is a hydroxycinnamic acid that is commonly found in fruits, vegetables, and grains. Like cis-Caffeic acid, Ferulic acid is known for its antioxidant properties and its ability to scavenge free radicals in the body.
Sinapic acid is another compound with a molecular structure similar to cis-Caffeic acid. Sinapic acid is a trans-hydroxycinnamic acid that is found in various plant sources. It exhibits antioxidant properties and is known for its potential health benefits, including reducing inflammation and protecting against oxidative stress.
One more compound similar to cis-Caffeic acid is Chlorogenic acid. Chlorogenic acid is an ester formed between trans-cinnamic acid and quinic acid. It is commonly found in coffee, fruits, and vegetables. Chlorogenic acid is known for its antioxidant properties and its potential health benefits, including improving heart health and reducing inflammation.
