8,15-Dihydroxy-5,9,11,13-eicosatetraenoic acid, also known as 8,15-diHETE, is a highly potent metabolite derived from the oxidation of arachidonic acid and plays a crucial role in various physiological processes such as inflammation, immune responses, and cell signaling. This compound is of significant relevance to everyday life as it affects the body’s response to injury, infection, and disease. Understanding the functions and mechanisms of 8,15-diHETE can provide valuable insights for the development of potential therapeutic strategies for various health conditions.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
8,15-Dihydroxy-5,9,11,13-eicosatetraenoic acid, also known as 8,15-diHETE, has various commercial and industrial applications. The compound is used in the production of cosmetics and skincare products due to its anti-inflammatory properties. Additionally, it is utilized in the manufacturing of pharmaceuticals for its potential roles in promoting wound healing and tissue repair.
In the realm of drug and medication applications, 8,15-Dihydroxy-5,9,11,13-eicosatetraenoic acid shows promise in the development of treatments for inflammatory conditions. The compound has been researched for its potential as an anti-inflammatory agent in diseases such as arthritis and asthma. Furthermore, 8,15-diHETE has been studied for its role in modulating immune responses and could potentially be used in immunotherapy.
Overall, 8,15-Dihydroxy-5,9,11,13-eicosatetraenoic acid holds significant potential in various commercial and industrial sectors, as well as in the development of novel drug therapies. Further research and development in these areas could lead to valuable applications of this compound in improving human health and well-being.
⚗️ Chemical & Physical Properties
8,15-Dihydroxy-5,9,11,13-eicosatetraenoic acid, commonly known as 8,15-DiHETE, appears as a colorless to pale yellow solid with no distinct odor. This compound is a derivative of arachidonic acid and is important in the inflammatory response within the body.
The molar mass of 8,15-DiHETE is approximately 320.43 g/mol, and it has a density of 1.02 g/mL. In comparison to common food items, this compound’s molar mass falls within the range of proteins and carbohydrates, while its density is similar to that of vegetable oils.
The melting point of 8,15-DiHETE is around 75-77°C, and its boiling point is approximately 388-390°C. These values are higher than those of most common food items, such as sugars and fats, which typically have lower melting and boiling points.
8,15-DiHETE is sparingly soluble in water and exhibits low viscosity. In comparison to common food items, this compound’s solubility in water is similar to that of lipids and fats, while its viscosity is lower than that of sugars and proteins.
🏭 Production & Procurement
In the realm of biochemistry, 8,15-Dihydroxy-5,9,11,13-eicosatetraenoic acid is produced through the enzymatic oxidation of arachidonic acid. This transformation is catalyzed by lipoxygenase enzymes, which introduce hydroxyl groups at the 8th and 15th positions of the eicosatetraenoic acid chain. This unique acid serves as a crucial intermediate in the biosynthesis of various lipid mediators, including leukotrienes and lipoxins.
The procurement of 8,15-Dihydroxy-5,9,11,13-eicosatetraenoic acid typically involves its isolation from biological samples or chemical synthesis. Researchers frequently extract this compound from cells or tissues using organic solvents and purification techniques. Once acquired, 8,15-Dihydroxy-5,9,11,13-eicosatetraenoic acid can be preserved in suitable storage conditions, such as low temperatures, to maintain its stability and integrity during transportation.
When transporting 8,15-Dihydroxy-5,9,11,13-eicosatetraenoic acid, it is essential to employ proper handling protocols to prevent degradation or contamination of the compound. Sealed containers and inert gas environments may be utilized to safeguard the stability of this acid during transit. Additionally, adherence to regulatory guidelines and safety practices is crucial to ensure the secure handling and transport of 8,15-Dihydroxy-5,9,11,13-eicosatetraenoic acid in scientific research settings.
⚠️ Safety Considerations
Safety considerations for 8,15-Dihydroxy-5,9,11,13-eicosatetraenoic acid must be taken seriously due to its potential hazards. This compound is a potent inflammatory mediator and leukotriene that can induce bronchoconstriction and increase vascular permeability. Inhalation or ingestion of this substance can lead to respiratory irritation, skin sensitization, and eye irritation. Therefore, proper protective equipment, such as gloves, goggles, and a lab coat, should be worn when working with this compound to prevent exposure.
Hazard statements for 8,15-Dihydroxy-5,9,11,13-eicosatetraenoic acid include “Causes skin irritation,” “Causes serious eye irritation,” and “May cause respiratory irritation.” These statements highlight the potential dangers associated with handling this compound without proper precautions. It is important to be aware of these hazards and take necessary steps to minimize the risks of exposure.
Precautionary statements for 8,15-Dihydroxy-5,9,11,13-eicosatetraenoic acid emphasize the importance of following safety protocols when working with this compound. Some key precautionary statements include “Wear protective gloves/eye protection/face protection” and “IF ON SKIN: Wash with plenty of soap and water.” These statements serve as guidelines for handling 8,15-Dihydroxy-5,9,11,13-eicosatetraenoic acid safely and reducing the likelihood of adverse health effects. It is essential to adhere to these precautions to ensure the well-being of individuals handling this compound.
🔬 Potential Research Directions
Research on 8,15-Dihydroxy-5,9,11,13-eicosatetraenoic acid, also known as 8,15-diHETE, may focus on its roles in inflammation and immune response regulation.
Investigations may explore the impact of 8,15-diHETE on vascular function, platelet aggregation, and smooth muscle cell proliferation.
Studies on the potential therapeutic applications of 8,15-diHETE in various conditions, such as cardiovascular disease and cancer, might also be a promising research direction.
🧪 Related Compounds
One similar compound to 8,15-Dihydroxy-5,9,11,13-eicosatetraenoic acid is 5,8,11,14-Eicosatetraynoic acid. This compound also contains a 20-carbon chain with four double bonds, similar to 8,15-Dihydroxy-5,9,11,13-eicosatetraenoic acid. The presence of additional hydroxyl groups in the latter compound distinguishes it from 5,8,11,14-Eicosatetraynoic acid.
Another similar compound is 8,11,14-Eicosatrienoic acid, which shares the same 20-carbon chain length with 8,15-Dihydroxy-5,9,11,13-eicosatetraenoic acid. The difference lies in the position and number of double bonds in the molecule. While 8,15-Dihydroxy-5,9,11,13-eicosatetraenoic acid has hydroxyl groups at specific positions, 8,11,14-Eicosatrienoic acid contains unsaturated bonds at different locations.
