8-Amino-7-oxononanoic acid, also known as AONA, is a key component of the biosynthetic pathway for the production of biotin, a vital nutrient essential for human health. Biotin plays a crucial role in various metabolic processes in the body, including glucose utilization, fatty acid synthesis, and amino acid metabolism. From a dietary perspective, adequate intake of biotin is necessary for proper growth, maintenance, and overall well-being. Therefore, understanding the significance of AONA in the synthesis of biotin underscores its relevance to everyday life in maintaining optimal health.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
In commercial and industrial applications, 8-Amino-7-oxononanoic acid is primarily used as a precursor in the production of biodegradable polymers. These polymers have a wide range of applications, including packaging materials, textiles, and medical devices. Additionally, this compound is utilized in the synthesis of pharmaceutical intermediates and as a chelating agent in metal ion removal processes.
In drug and medication applications, 8-Amino-7-oxononanoic acid is used in the production of certain antibiotics and antifungal agents. It serves as a key building block in the synthesis of these drugs, providing structural integrity and biological activity. Furthermore, this compound can be employed in the development of anti-cancer medications and other therapeutic agents due to its ability to target specific cellular processes involved in disease progression.
⚗️ Chemical & Physical Properties
8-Amino-7-oxononanoic acid appears as a white crystalline solid with no distinctive odor.
The molar mass of 8-Amino-7-oxononanoic acid is approximately 189.24 g/mol, and its density is around 1.25 g/cm³. This molar mass and density are similar to common household items like table salt and sugar.
The melting point of 8-Amino-7-oxononanoic acid is approximately 160-165°C, while its boiling point is around 350-360°C. These values are higher compared to common household items like water and cooking oil.
8-Amino-7-oxononanoic acid is slightly soluble in water and has a low viscosity. Its solubility in water and viscosity are lower compared to common household items like salt and honey.
🏭 Production & Procurement
Production of 8-Amino-7-oxononanoic acid involves a series of chemical reactions starting from nonanoic acid. Nonanoic acid is first oxidized to form 8-oxononanoic acid, which is then treated with ammonia to introduce the amino group and yield the final product.
Procurement of 8-Amino-7-oxononanoic acid can be achieved through chemical suppliers or specialized manufacturers. The compound is typically supplied in its solid form, either as a pure substance or as a component of a chemical mixture. Transportation of 8-Amino-7-oxononanoic acid is done in accordance with regulations for handling hazardous chemicals to ensure safety and compliance.
⚠️ Safety Considerations
Safety considerations for 8-Amino-7-oxononanoic acid include proper storage and handling to prevent any accidental exposure. It is important to store this compound in a cool, dry place away from incompatible materials. Personal protective equipment such as gloves, lab coat, and safety goggles should be worn when working with this substance to minimize the risk of skin contact or inhalation of vapors.
The pharmacology of 8-Amino-7-oxononanoic acid involves its role as a precursor in the biosynthesis of the essential neurotransmitter γ-aminobutyric acid (GABA) in the brain. GABA is known for its inhibitory effects in the central nervous system, which play a crucial role in regulating neuronal excitability. Therefore, 8-Amino-7-oxononanoic acid indirectly affects neurotransmission by influencing the availability of GABA, leading to various physiological and pharmacological effects.
The hazard statements for 8-Amino-7-oxononanoic acid include potential skin and eye irritation upon contact. This compound may also cause respiratory irritation if inhaled. It is important to avoid ingestion and to seek medical attention immediately in case of exposure. Additionally, 8-Amino-7-oxononanoic acid may have harmful effects on aquatic organisms, so precautions should be taken to prevent environmental contamination.
Precautionary statements for 8-Amino-7-oxononanoic acid include avoiding direct contact with the substance and utilizing appropriate engineering controls such as fume hoods when handling. Proper ventilation should be maintained in the working area to prevent the accumulation of vapors. In case of accidental exposure, thorough washing of the affected area with water and seeking medical advice is recommended. Proper disposal methods in compliance with local regulations should also be followed to minimize environmental impact.
🔬 Potential Research Directions
One potential research direction for 8-Amino-7-oxononanoic acid is its role in the biosynthesis of biologically active compounds, such as antibiotics or antifungal agents.
Researchers may also investigate the potential therapeutic applications of 8-Amino-7-oxononanoic acid, particularly in targeting specific metabolic pathways or enzymes involved in certain diseases.
Furthermore, studies could focus on the chemical properties and reactivity of 8-Amino-7-oxononanoic acid, exploring its potential use as a building block in organic synthesis or in the development of novel pharmaceutical compounds.
🧪 Related Compounds
One similar compound to 8-Amino-7-oxononanoic acid based on molecular structure is 6-Amino-5-oxoheptanoic acid. This compound consists of a seven-carbon chain with an amino group on the sixth carbon and a ketone group on the fifth carbon. The presence of both amino and keto functional groups makes it structurally similar to 8-Amino-7-oxononanoic acid.
Another compound with a similar structure to 8-Amino-7-oxononanoic acid is 9-Amino-8-oxodecanoic acid. This compound contains a ten-carbon chain with an amino group on the ninth carbon and a ketone group on the eighth carbon. The additional carbon in the chain differentiates it from 8-Amino-7-oxononanoic acid, but the presence of the amino and keto functional groups maintains structural similarity.
A third compound that shares a structural likeness to 8-Amino-7-oxononanoic acid is 5-Amino-4-oxopentanoic acid. This compound features a five-carbon chain with an amino group on the fourth carbon and a ketone group on the third carbon. The shorter carbon chain distinguishes it from 8-Amino-7-oxononanoic acid, but the presence of the same functional groups imparts a similar molecular structure.
