7-Methoxycoumarin, a derivative of the natural substance coumarin, plays a crucial role in various industries and applications. Specifically, it is widely used in the production of fragrances, cosmetics, and pharmaceuticals due to its pleasant odor and potential therapeutic properties. In everyday life, consumers may encounter products containing 7-Methoxycoumarin without realizing its presence, highlighting its significance in enhancing sensory experiences and contributing to the efficacy of certain personal care items.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
7-Methoxycoumarin, also known as umbelliferone, has various commercial and industrial applications. It is used in the cosmetic industry as a fragrance ingredient for its pleasant scent. Additionally, it is utilized in the food industry as a flavoring agent due to its sweet and aromatic qualities.
In drug and medication applications, 7-Methoxycoumarin is used in the pharmaceutical industry as a precursor for the synthesis of coumarin derivatives. These derivatives have been found to have anticoagulant and anti-inflammatory properties, making them useful in the treatment of various medical conditions. Furthermore, 7-Methoxycoumarin is used in research laboratories for its fluorescent properties, allowing for the visualization of specific molecules in biological samples.
⚗️ Chemical & Physical Properties
7-Methoxycoumarin is a white crystalline solid with a faint odor. It is typically odorless in pure form, with a slight fragrance when dissolved in solvents.
With a molar mass of 192.19 g/mol and a density of 1.25 g/cm³, 7-Methoxycoumarin is heavier and more compact than common food items like salt and sugar. Its molar mass falls within the range of small organic molecules commonly found in nature.
7-Methoxycoumarin has a melting point of 94-96 °C and a boiling point of 304 °C. Compared to common food items like butter and olive oil, it has a higher melting point and boiling point, indicating a higher level of stability under heat.
This compound is sparingly soluble in water and exhibits low viscosity. When compared to common food items like vinegar and honey, 7-Methoxycoumarin’s solubility and viscosity are lower, making it less likely to form homogeneous mixtures in aqueous environments.
🏭 Production & Procurement
7-Methoxycoumarin is synthesized through the demethylation of 7-Methoxycoumarin acetate using either hydrochloric acid or sulfuric acid as a catalyst. This process involves heating the mixture at a specific temperature under controlled conditions to facilitate the demethylation reaction.
Once 7-Methoxycoumarin is produced, it can be procured through chemical suppliers or pharmaceutical companies specializing in fine chemicals. The compound is typically supplied in a solid form, often as a white to off-white powder, and is packaged in airtight containers to ensure its stability during transportation.
Transportation of 7-Methoxycoumarin typically involves the use of specialized chemical transport companies or courier services equipped to handle hazardous or sensitive materials. Proper labeling and documentation are essential to comply with regulatory requirements and ensure the safe delivery of the compound to the desired destination.
⚠️ Safety Considerations
Safety considerations for 7-Methoxycoumarin must be taken seriously due to its potential hazards. This compound is harmful if swallowed, inhaled, or in contact with skin. It may cause irritation to the respiratory system, skin, and eyes. Additionally, it is flammable and should be stored away from heat sources or open flames. Proper protective equipment, such as gloves, goggles, and a lab coat, should be worn when handling this chemical to minimize the risk of exposure.
Hazard statements for 7-Methoxycoumarin include “Harmful if swallowed, inhaled, or in contact with skin”, “Causes skin, eye, and respiratory tract irritation”, and “May be flammable”. These statements highlight the potential dangers associated with this compound and emphasize the importance of proper handling and storage to prevent accidents or injuries.
Precautionary statements for 7-Methoxycoumarin provide guidance on safe handling practices to minimize risks to human health and the environment. It is recommended to wear protective gloves, clothing, eye protection, and respiratory protection when working with this compound. In case of skin contact, rinse immediately with plenty of water and seek medical advice. Inhalation should be avoided, and if respiratory irritation occurs, move to fresh air. Spills should be cleaned up immediately, and the compound should be stored in a cool, dry place away from heat sources.
🔬 Potential Research Directions
One potential research direction for 7-Methoxycoumarin is its potential use as a fluorescent probe for detecting biomolecules in biological systems.
Another avenue for investigation is exploring the potential therapeutic applications of 7-Methoxycoumarin, such as its anti-inflammatory or antioxidant properties.
Additionally, further research could be directed towards investigating the chemical synthesis of 7-Methoxycoumarin derivatives with enhanced bioactivity or improved pharmacokinetic properties.
Exploring the potential effects of 7-Methoxycoumarin on various cellular processes or pathways could provide valuable insights into its biological mechanisms of action.
🧪 Related Compounds
One similar compound to 7-Methoxycoumarin based on molecular structure is 4-Methoxycoumarin. This compound has a methoxy group attached at the 4-position on the coumarin ring, similar to 7-Methoxycoumarin which has the methoxy group at the 7-position. Despite the difference in position of the methoxy group, both compounds share similar chemical properties due to the presence of the methoxy group on the coumarin ring.
Another related compound is 6-Methoxycoumarin, which bears a methoxy group at the 6-position on the coumarin ring. Similar to 7-Methoxycoumarin, this compound exhibits comparable chemical behavior due to the methoxy group affecting the reactivity and biological activity of the molecule. The positional isomerism of the methoxy group results in differences in physical and chemical properties, but overall, these compounds share structural similarities.
Additionally, 5-Methoxycoumarin is another compound closely related to 7-Methoxycoumarin. With a methoxy group attached at the 5-position on the coumarin ring, this compound shares similar aromatic properties and reactivity. Despite the positional isomerism, 5-Methoxycoumarin is likely to exhibit similar biological activity to 7-Methoxycoumarin due to the presence of the methoxy group on the coumarin scaffold.
