7-Aminoquinoline may not be a household name, but its impact on everyday life is significant. This compound is widely used in the pharmaceutical industry, where it serves as a building block for the synthesis of several important drugs, including antimalarials and antitumor agents. Additionally, 7-Aminoquinoline plays a crucial role in the field of organic chemistry, where it is utilized in various reactions to create new compounds with diverse applications. As such, the relevance of 7-Aminoquinoline extends beyond the confines of the laboratory, influencing the development of medicines and materials that impact our daily lives.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
7-Aminoquinoline, a derivative of quinoline, has several commercial and industrial applications. It is commonly used as a building block for the synthesis of various pharmaceuticals, agrochemicals, and dyes. Additionally, 7-Aminoquinoline is utilized in the manufacturing of certain specialty chemicals and as a reagent in chemical analysis processes.
In terms of drug and medication applications, 7-Aminoquinoline is primarily known for its antimalarial properties. It is an important component in the production of antimalarial drugs such as chloroquine and amodiaquine. These medications have been instrumental in the treatment and prevention of malaria, a deadly disease caused by the Plasmodium parasite transmitted through mosquito bites.
⚗️ Chemical & Physical Properties
In its pure form, 7-Aminoquinoline appears as a white crystalline solid with no distinct odor.
The molar mass of 7-Aminoquinoline is approximately 144.18 g/mol, and its density is around 1.154 g/cm^3. In comparison to common food items, 7-Aminoquinoline has a lower molar mass and higher density.
7-Aminoquinoline has a melting point of 121-124°C and a boiling point of 292-295°C. These values are significantly higher than those of common food items, which typically have much lower melting and boiling points.
7-Aminoquinoline is sparingly soluble in water and has a relatively low viscosity. In contrast, common food items are often highly soluble in water and have viscosities that vary widely.
🏭 Production & Procurement
7-Aminoquinoline is typically produced through the reaction of 4-chloroquinoline with aqueous ammonia at elevated temperatures. This process results in the formation of 7-Aminoquinoline along with ammonium chloride as a byproduct. Various purification techniques can be employed to isolate the desired product in its pure form.
7-Aminoquinoline can be procured through chemical suppliers or pharmaceutical companies that specialize in the production of fine chemicals. The compound is commonly available in both bulk quantities and smaller quantities suitable for research purposes. Transportation of 7-Aminoquinoline can be done using standard shipping methods, ensuring compliance with all relevant regulations and safety precautions.
Upon procurement, 7-Aminoquinoline should be stored in a cool, dry place away from direct sunlight and moisture to maintain its stability and shelf life. Proper labeling and handling procedures should be followed to minimize the risk of accidental exposure or contamination. It is essential to adhere to all storage and handling guidelines provided by the supplier to ensure the quality and integrity of the compound.
⚠️ Safety Considerations
Safety considerations for 7-Aminoquinoline involve handling the chemical with care due to its potential hazards. It is important to wear appropriate personal protective equipment, such as gloves and goggles, when working with 7-Aminoquinoline to prevent skin and eye irritation. Additionally, the chemical should be stored in a well-ventilated area away from incompatible substances to avoid potential reactions or accidents.
Hazard statements for 7-Aminoquinoline include the chemical being harmful if swallowed, causing skin irritation, and potentially causing serious eye damage. It is also considered toxic to aquatic life with long-lasting effects. Therefore, it is crucial to handle 7-Aminoquinoline with caution and implement appropriate safety measures to prevent exposure.
Precautionary statements for 7-Aminoquinoline involve avoiding ingestion, inhalation, and skin contact with the chemical. If handling 7-Aminoquinoline, it is recommended to wear protective gloves, clothing, and eye protection to minimize the risk of exposure. In case of accidental exposure, it is important to seek medical attention immediately and provide the relevant information about the chemical for proper treatment.
🔬 Potential Research Directions
Research on 7-Aminoquinoline has potential directions in various fields, including medicinal chemistry and pharmaceutical science. Studies may focus on exploring the biological activities and pharmacological properties of this compound, especially in the development of new drugs for the treatment of infectious diseases or cancer.
Further investigations could delve into the synthesis and modification of 7-Aminoquinoline derivatives to enhance their efficacy and specificity. Structural optimization studies may aim to improve the pharmacokinetic profiles and reduce potential toxicity of these compounds, paving the way for future drug development.
Additionally, research on the mechanisms of action of 7-Aminoquinoline and its derivatives could shed light on their interaction with molecular targets and signal transduction pathways. Understanding these aspects may provide insights into new therapeutic strategies and potential applications in personalized medicine.
🧪 Related Compounds
One similar compound to 7-Aminoquinoline based upon molecular structure is Chloroquine. Chloroquine contains a quinoline ring structure like 7-Aminoquinoline but has a chloro substituent at the 4-position of the quinoline ring. This compound is used as an antimalarial medication due to its ability to interfere with the growth of parasites in the red blood cells of infected individuals.
Another related compound is Amodiaquine, which is an aminoquinoline derivative with similar antimalarial properties to Chloroquine. Amodiaquine contains an additional amino group on the side chain, leading to enhanced biological activity against malaria parasites. This compound is used in combination therapy for the treatment of malaria, particularly in regions where parasites have developed resistance to other antimalarial drugs.
Mefloquine is another compound with a structure similar to 7-Aminoquinoline, featuring a quinoline ring fused to a piperidine ring. Mefloquine is also used as an antimalarial medication due to its ability to disrupt the growth and reproduction of malaria parasites in the body. This compound is often prescribed for prevention and treatment of malaria in travelers to regions where the disease is prevalent.
Primaquine is an additional compound related to 7-Aminoquinoline, containing a quinoline ring structure with an additional side chain. Primaquine is used for the treatment and prevention of relapses of malaria caused by Plasmodium vivax and Plasmodium ovale parasites. This compound is particularly effective at eliminating the dormant liver forms of the parasite, helping to prevent future malaria infections.
