6-Hydroxynicotinic acid is a compound with significance in the pharmaceutical industry due to its potential therapeutic applications. It has been studied for its potential as an anti-inflammatory and antioxidant agent, as well as for its possible role in treating neurological disorders. Research on this compound could ultimately lead to the development of new medications with a wide range of health benefits for individuals in everyday life.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
6-Hydroxynicotinic acid, also known as 6-HNA, is a compound with various commercial and industrial applications. It is commonly used as a precursor in the synthesis of pharmaceuticals, agrochemicals, and fluorescent dyes. Its ability to act as a chelating agent also makes it useful in metal ion detection and separation processes.
In drug and medication applications, 6-Hydroxynicotinic acid is utilized in the development of antitumor agents and anti-inflammatory drugs. Its antioxidant properties make it valuable in the prevention of cellular damage and oxidative stress-related diseases. Additionally, 6-HNA has shown promise in the treatment of neurological disorders such as Alzheimer’s disease and Parkinson’s disease.
Overall, 6-Hydroxynicotinic acid plays a significant role in both commercial and pharmaceutical industries. Its versatile properties make it a valuable compound for various applications, ranging from industrial processes to drug development. Researchers continue to explore its potential uses in different fields, highlighting its importance as a key component in modern chemistry and medicine.
⚗️ Chemical & Physical Properties
6-Hydroxynicotinic acid is a white crystalline solid that has no distinct odor. Its appearance is similar to other organic acids commonly found in nature.
With a molar mass of 167.13 g/mol and a density of 1.46 g/cm^3, 6-Hydroxynicotinic acid falls within the range of molar mass and density of many common food items, such as sugars and organic acids.
6-Hydroxynicotinic acid has a melting point of 220-223°C and a boiling point of 530-532°C. These values are significantly higher than those of most common food items, which typically have lower melting and boiling points.
6-Hydroxynicotinic acid is highly soluble in water and has a low viscosity. In comparison to common food items, it exhibits greater solubility in water and lower viscosity, making it easier to dissolve and mix in aqueous solutions.
🏭 Production & Procurement
In the production of 6-Hydroxynicotinic acid, it is typically synthesized through the hydroxylation of nicotinic acid. This process involves the reaction of nicotinic acid with a suitable oxidant, such as hydrogen peroxide, under specific conditions to introduce a hydroxyl group at the 6-position of the pyridine ring.
6-Hydroxynicotinic acid can be procured from various chemical suppliers or manufacturers who specialize in the production of organic acids and derivatives. It is typically available in the form of a white crystalline powder or solid, and can be purchased in bulk quantities for industrial or research purposes. Following procurement, the compound can be transported via standard shipping methods, such as ground or air freight, in accordance with regulations governing the transport of hazardous or sensitive materials.
Alternatively, 6-Hydroxynicotinic acid can be synthesized in a laboratory setting using the appropriate reagents and equipment. Researchers or chemists may opt to produce the compound in-house to ensure its purity and quality for specific applications or experiments. The synthesis of 6-Hydroxynicotinic acid from nicotinic acid involves several steps and reaction conditions that must be carefully controlled to yield the desired product efficiently and with high purity.
⚠️ Safety Considerations
Safety considerations for 6-Hydroxynicotinic acid include potential skin and eye irritation upon contact. It is important to wear appropriate personal protective equipment such as gloves and goggles when handling this compound. Additionally, good ventilation should be maintained to prevent inhalation of any vapors that may be released.
Furthermore, 6-Hydroxynicotinic acid should be stored in a cool, dry place away from direct sunlight and incompatible materials. It is essential to follow proper storage guidelines to avoid any potential chemical reactions or degradation of the compound. In case of spills, it is important to clean up promptly using appropriate containment and disposal methods to prevent any environmental contamination or harm.
Hazard statements for 6-Hydroxynicotinic acid may include “Causes skin irritation” and “Causes serious eye irritation.” These statements indicate the potential risks associated with direct contact with the compound. It is important to take necessary precautions to avoid skin and eye exposure, such as wearing protective clothing and eyewear when handling 6-Hydroxynicotinic acid. In case of contact, it is advisable to rinse affected areas thoroughly with water and seek medical attention if necessary.
Precautionary statements for 6-Hydroxynicotinic acid may include “Avoid breathing dust/fume/gas/mist/vapors/spray” and “Wash hands and face thoroughly after handling.” These statements emphasize the importance of taking preventive measures to minimize exposure to the compound. It is crucial to work in a well-ventilated area and wash hands and face after handling 6-Hydroxynicotinic acid to prevent any potential health risks. Following these precautionary statements can help ensure safe handling of the compound and reduce the likelihood of adverse effects.
🔬 Potential Research Directions
Research on 6-Hydroxynicotinic acid is a promising area due to its potential therapeutic applications. Studies could explore its antioxidant properties and its ability to combat oxidative stress-related diseases.
Further research directions may involve investigating the interactions of 6-Hydroxynicotinic acid with different cellular pathways. Understanding how this compound modulates various signaling pathways could provide insights into its mechanisms of action and therapeutic potential.
Exploration of the pharmacokinetics and pharmacodynamics of 6-Hydroxynicotinic acid is essential for assessing its safety and efficacy in clinical settings. Research could focus on optimizing dosage regimens and identifying potential drug-drug interactions.
Investigations into the synthesis and formulation of 6-Hydroxynicotinic acid analogs may open up new avenues for drug development. Structural modifications could enhance its bioavailability and target specificity, leading to improved treatment options for various medical conditions.
🧪 Related Compounds
One similar compound to 6-Hydroxynicotinic acid is Nicotinic acid, also known as niacin or vitamin B3. Nicotinic acid shares a similar molecular structure to 6-Hydroxynicotinic acid, with both compounds containing a pyridine ring. However, Nicotinic acid lacks the hydroxyl group present in the 6-Hydroxynicotinic acid molecule. Nicotinic acid is widely used as a dietary supplement due to its role in energy metabolism and maintenance of healthy skin.
Another compound similar to 6-Hydroxynicotinic acid is Nicotinamide, also known as niacinamide or vitamin B3. Nicotinamide is structurally related to Nicotinic acid, with both compounds containing the pyridine ring. However, Nicotinamide lacks the carboxylic acid group found in Nicotinic acid, making it less acidic than its counterpart. Nicotinamide is commonly used in skincare products for its anti-inflammatory and antioxidant properties.
A third compound similar to 6-Hydroxynicotinic acid is Isophthalic acid, a benzene-1,3-dicarboxylic acid. While Isophthalic acid does not contain a pyridine ring like 6-Hydroxynicotinic acid, it shares a similar molecular structure in terms of the arrangement of carboxylic acid groups. Isophthalic acid is commonly used in the production of polymers such as polyethylene terephthalate (PET) and as a precursor in the synthesis of pharmaceuticals and dyes.
