6-Aminoquinoline is a chemical compound that has several practical applications in everyday life. It is frequently utilized in the pharmaceutical industry as a building block for the synthesis of various drugs, particularly antimalarial medications. Additionally, 6-Aminoquinoline is utilized in scientific research as a ligand for metal complexes, with potential applications in catalysis and materials science. The compound’s versatile properties make it a valuable asset in both the development of new drugs and advancements in chemical research.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
6-Aminoquinoline is a compound with various commercial and industrial applications. It is commonly used as a chemical intermediate in the synthesis of pharmaceuticals, dyes, and agrochemicals. Additionally, 6-Aminoquinoline is utilized in the manufacturing of corrosion inhibitors, antioxidants, and rubber additives.
In the realm of drug and medication applications, 6-Aminoquinoline plays a significant role in the pharmaceutical industry. It is a key precursor in the synthesis of antimalarial drugs, such as chloroquine and amodiaquine. These drugs are essential in the treatment and prevention of malaria, a disease that affects millions of people worldwide each year.
⚗️ Chemical & Physical Properties
6-Aminoquinoline is a white crystalline solid with no distinctive odor. It is commonly used in organic synthesis and pharmaceutical research due to its unique properties.
The molar mass of 6-Aminoquinoine is approximately 144.17 g/mol, with a density of 1.158 g/cm³. This puts it in the same range as common food items like table salt in terms of molar mass and density.
6-Aminoquinoline has a melting point of 61-65°C and a boiling point of 270-275°C. These values are much higher compared to most common food items, which typically have lower melting and boiling points.
6-Aminoquinoline is slightly soluble in water, with a viscosity similar to that of vegetable oil. This makes it less soluble in water and more viscous compared to most common food items like sugar or salt, which dissolve readily and have low viscosity.
🏭 Production & Procurement
6-Aminoquinoline is typically produced through the condensation of o-phenylenediamine with diethyl 2-chloromalonate. The resulting compound is then cyclized to form 6-Aminoquinoline, which can be further purified through crystallization or recrystallization methods.
6-Aminoquinoline can be procured through various chemical suppliers or pharmaceutical companies that specialize in manufacturing and distributing specialty chemicals. It is typically transported in sealed containers to prevent exposure to air or moisture, which can degrade the compound. Proper labeling and documentation are required for the safe handling and transportation of 6-Aminoquinoline.
Upon procurement, 6-Aminoquinoline should be stored in a cool, dry place away from direct sunlight and moisture to prevent degradation. It is important to follow all safety guidelines and regulations for handling and storing this compound, as it can be toxic if mishandled. Proper disposal methods should also be followed to prevent environmental contamination.
⚠️ Safety Considerations
Safety considerations for 6-Aminoquinoline must be carefully considered due to its potential hazards. This substance is known to cause skin and eye irritation upon contact, as well as respiratory irritation if inhaled. Ingestion or inhalation of 6-Aminoquinoline may cause harm to internal organs and pose a serious health risk. Therefore, proper personal protective equipment, such as gloves, goggles, and a respirator, should be worn when handling this chemical to minimize exposure.
Hazard statements for 6-Aminoquinoline include “causes skin and eye irritation” as well as “may cause damage to organs through prolonged or repeated exposure.” This substance is also labeled as harmful if swallowed or inhaled. It is important to minimize exposure to 6-Aminoquinoline and handle it with caution to prevent adverse health effects.
Precautionary statements for 6-Aminoquinoline include storing the chemical in a well-ventilated area away from heat sources and incompatible materials. It is essential to wear the appropriate personal protective equipment, such as gloves and goggles, when handling this substance to prevent skin and eye irritation. In case of accidental exposure, immediate medical attention and proper first aid measures should be taken to minimize health risks.
🔬 Potential Research Directions
One potential research direction for 6-Aminoquinoline is its use as an antimalarial agent, as this compound has shown promising activity against Plasmodium falciparum parasites in vitro.
Another area of interest could be investigating the cytotoxicity and anticancer properties of 6-Aminoquinoline, as some studies have suggested that it may have potential as a novel chemotherapeutic agent.
Furthermore, research could explore the potential of 6-Aminoquinoline in the field of photodynamic therapy, as its structure suggests that it may have photosensitizing properties that could be utilized in treating various diseases.
Additionally, studies could focus on the synthesis and modification of 6-Aminoquinoline derivatives to enhance its biological activity and drug-like properties, with the goal of developing more potent and selective compounds for therapeutic applications.
Further investigations could also delve into the mechanism of action of 6-Aminoquinoline, to elucidate how it interacts with its molecular targets and understand the pathways through which it exerts its pharmacological effects. This knowledge could inform the design of more effective drugs based on this compound.
🧪 Related Compounds
One similar compound to 6-Aminoquinoline is 7-Aminoquinoline, which differs by the position of the amino group on the quinoline ring. This compound exhibits similar chemical properties to 6-Aminoquinoline due to the presence of the amino group, allowing for hydrogen bonding and potential reactions with other molecules. 7-Aminoquinoline is commonly used in pharmaceutical research and organic synthesis due to its structural similarities with 6-Aminoquinoline.
Another related compound is 5-Aminoquinoline, which shares the quinoline ring structure with 6-Aminoquinoline but differs in the position of the amino group. This compound is also capable of forming hydrogen bonds and participating in various chemical reactions due to the presence of the amino group. 5-Aminoquinoline has been studied for its potential applications in medicinal chemistry and as a building block for the synthesis of biologically active molecules.
A third compound related to 6-Aminoquinoline is 8-Aminoquinoline, which possesses the quinoline ring structure and an amino group in a different position. Similar to the other aminoquinolines, 8-Aminoquinoline exhibits comparable chemical properties to 6-Aminoquinoline owing to the presence of the amino group. This compound has been investigated for its potential biological activities and as a precursor in the synthesis of novel compounds for pharmaceutical applications.
