5-Aminoquinoline, a chemical compound derived from quinoline, plays a crucial role in modern society. This versatile compound is widely used in the pharmaceutical industry for the synthesis of various drugs, including antimalarials such as chloroquine and primaquine. These drugs have been instrumental in the treatment and prevention of malaria, a life-threatening disease that affects millions of people worldwide. Additionally, 5-Aminoquinoline is utilized in research laboratories as a key building block for the development of new therapeutic agents. Its significance in everyday life lies in its contribution to advancing healthcare and potentially saving lives.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
5-Aminoquinoline, also commonly referred to as 5AQ, has various commercial and industrial applications. It is often used as a building block in the synthesis of pharmaceuticals, agrochemicals, and dyes. Additionally, it is utilized in the manufacturing of corrosion inhibitors, rubber accelerators, and photographic chemicals due to its chemical properties.
In the realm of drug and medication applications, 5-Aminoquinoline plays a crucial role in the synthesis of antimalarial drugs such as chloroquine and primaquine. These drugs are essential in the treatment and prevention of malaria, a life-threatening disease caused by parasites transmitted through mosquito bites. The unique structure of 5-Aminoquinoline enables it to effectively combat the malaria parasite within the human body.
Furthermore, 5-Aminoquinoline has shown promise in recent research for its potential anti-cancer properties. Studies have indicated that this compound may have the ability to inhibit the growth of certain types of cancer cells, making it a subject of interest in the development of new cancer treatments. Its versatility and effectiveness in both commercial and medical applications have solidified its importance in various industries.
⚗️ Chemical & Physical Properties
5-Aminoquinoline is a solid compound with a white to yellowish color and a faint odor. It is commonly used in the synthesis of pharmaceuticals and dyes due to its unique chemical properties.
The molar mass of 5-Aminoquinoline is approximately 144.17 g/mol, and its density is around 1.08 g/cm³. Compared to common food items such as sugar (molar mass of 342.30 g/mol, density of 1.59 g/cm³), 5-Aminoquinoline has a lower molar mass and density.
5-Aminoquinoline has a melting point of around 82-85°C and a boiling point of approximately 206-208°C. Compared to common food items like butter (melting point of 32-35°C, boiling point of 150-220°C), 5-Aminoquinoline has a higher melting and boiling point.
5-Aminoquinoline is sparingly soluble in water and has a low viscosity. Compared to common food items like salt (high solubility in water, low viscosity) 5-Aminoquinoline has low solubility and viscosity in water.
🏭 Production & Procurement
5-Aminoquinoline, also known as 5AQ, is primarily produced through a synthetic process involving the reaction of 4,7-dichloroquinoline with ammonia. This reaction results in the formation of 5-Aminoquinoline, which is then purified through various methods such as crystallization or chromatography.
The procurement of 5-Aminoquinoline typically involves sourcing the compound from chemical suppliers or manufacturers. Due to its specialized production process, 5-Aminoquinoline may not be readily available in all regions, and thus specialized suppliers may need to be contacted for procurement. Once obtained, 5-Aminoquinoline can be transported using standard chemical transport methods, ensuring proper handling and storage to maintain its stability.
In the context of research or industrial applications, 5-Aminoquinoline may be procured in bulk quantities to meet specific needs. This may involve custom orders from manufacturers or suppliers with the capacity to produce and supply larger quantities of the compound. Transportation of bulk quantities of 5-Aminoquinoline may require specialized packaging and handling procedures to ensure safety and compliance with regulations.
⚠️ Safety Considerations
Safety considerations for 5-Aminoquinoline should be taken with utmost seriousness due to its potential hazards. As with most chemicals, exposure to 5-Aminoquinoline should be limited through the use of appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It is also important to handle this substance in a well-ventilated area to prevent inhalation of toxic fumes. Additionally, proper storage and labeling of 5-Aminoquinoline are crucial to avoid accidental ingestion or misuse.
Hazard statements for 5-Aminoquinoline include its ability to cause skin and eye irritation upon contact, as well as respiratory irritation if inhaled. It is also classified as a possible skin sensitizer, meaning repeated exposure may lead to allergic reactions. Furthermore, 5-Aminoquinoline is considered harmful if swallowed and can cause serious health effects if not handled properly. It is essential to be aware of these hazards and take necessary precautions when working with this chemical.
Precautionary statements for 5-Aminoquinoline include the recommendation to wear appropriate PPE at all times when handling the substance. This includes gloves, goggles, and a lab coat to protect the skin, eyes, and clothing from potential exposure. It is also important to work in a well-ventilated area to prevent inhalation of fumes and to avoid ingestion of the chemical. Furthermore, proper storage of 5-Aminoquinoline in a tightly sealed container away from incompatible materials is crucial to prevent accidents and spills. Taking these precautionary measures can help ensure the safety of individuals working with this chemical.
🔬 Potential Research Directions
Potential research directions for 5-Aminoquinoline include its application in the development of antimalarial drugs, due to its known efficacy in treating malaria. Research may focus on investigating the underlying mechanisms of action by which 5-Aminoquinoline exhibits antimalarial activity, to further optimize its therapeutic potential.
Furthermore, studies may explore the potential of 5-Aminoquinoline in the treatment of other parasitic diseases, such as amoebiasis and babesiosis. Research could investigate the effectiveness of 5-Aminoquinoline against various parasites, and elucidate its mode of action against different parasitic organisms.
Additionally, researchers may investigate the potential use of 5-Aminoquinoline as an anti-inflammatory agent, due to its reported anti-inflammatory properties. Studies could explore the impact of 5-Aminoquinoline on inflammatory pathways and its potential therapeutic benefits in diseases characterized by inflammation, such as rheumatoid arthritis and inflammatory bowel disease.
Moreover, research could focus on the development of novel derivatives or formulations of 5-Aminoquinoline to enhance its pharmacokinetic properties and improve its efficacy. Investigations may involve the synthesis of analogs with improved stability, solubility, and bioavailability, to overcome limitations associated with the current formulation of 5-Aminoquinoline.
Lastly, studies may investigate the potential neuroprotective effects of 5-Aminoquinoline, given its reported antioxidant properties. Research could explore the impact of 5-Aminoquinoline on cellular processes involved in neurodegeneration, and its potential therapeutic role in neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease.
🧪 Related Compounds
One similar compound to 5-Aminoquinoline is Chloroquine, which is also a synthetic derivative of quinoline. Chloroquine is commonly used as an antimalarial medication due to its ability to inhibit the growth of Plasmodium parasites in the blood. The molecular structure of Chloroquine is closely related to 5-Aminoquinoline, with a quinoline core and an amino group.
Another compound similar to 5-Aminoquinoline is Amodiaquine, which is also an antimalarial medication. Amodiaquine is structurally related to Chloroquine and 5-Aminoquinoline, with a quinoline core and an amino group. Amodiaquine works by interfering with the growth of Plasmodium parasites in the blood, similar to Chloroquine.
One more compound similar to 5-Aminoquinoline is Primaquine, which is used for the treatment and prevention of malaria. Primaquine is a synthetic derivative of quinoline, like 5-Aminoquinoline, and has a similar molecular structure. Primaquine works by killing the dormant liver forms of the malaria parasite, Plasmodium vivax, making it an essential component of malaria treatment regimens.
