4-Nitroquinoline-1-Oxide is a chemical compound that has been studied for its potential carcinogenic properties. Research on this substance is important in understanding the mechanisms of cancer development and identifying potential ways to prevent or treat the disease. While the average person may not come into direct contact with 4-Nitroquinoline-1-Oxide in their daily life, its study is crucial for public health and scientific advancement in the field of oncology.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
4-Nitroquinoline-1-Oxide, also known as 4-NQO, is widely used in commercial and industrial applications as a mutagen and carcinogen in genetic toxicology studies. It is commonly utilized in laboratories for testing the effects of various substances on DNA structure and function.
In addition to its commercial and industrial applications, 4-Nitroquinoline-1-Oxide has been used in drug and medication applications. This compound is often employed in research studies to induce tumors in animal models, aiding in the development of anti-cancer drugs and treatments. Its ability to cause DNA damage has made it a valuable tool in the study of cancer and genetic mutations.
Due to its mutagenic and carcinogenic properties, 4-Nitroquinoline-1-Oxide is not used directly in consumer products or medications intended for human use. However, its importance in scientific research cannot be understated, as it provides valuable insights into the mechanisms of cancer development and potential treatments. Researchers must handle this compound with care and adhere to strict safety protocols when utilizing it in laboratory settings.
⚗️ Chemical & Physical Properties
4-Nitroquinoline-1-Oxide is a pale yellow solid with a faint odor. It has a molecular formula of C9H7NO3 and a molar mass of 189.16 g/mol.
The density of 4-Nitroquinoline-1-Oxide is 1.419 g/cm3. This is higher than common household items such as water (1 g/cm3) and vegetable oil (0.92 g/cm3).
4-Nitroquinoline-1-Oxide has a melting point of 137-141°C and a boiling point of 381°C. These values are higher than common household items such as sugar (melting point of 186°C) and ethanol (boiling point of 78.37°C).
4-Nitroquinoline-1-Oxide is sparingly soluble in water and has a low viscosity. This differs from common household items such as salt (high solubility in water) and honey (high viscosity).
🏭 Production & Procurement
4-Nitroquinoline-1-Oxide, a potent mutagen and carcinogen, is typically produced through the oxidation of 4-nitroquinoline. This process involves the use of chemicals such as nitric acid and sulfuric acid, resulting in the formation of the desired compound.
To procure 4-Nitroquinoline-1-Oxide, one must seek out specialized chemical suppliers who have the capabilities to produce and supply the compound. Due to its hazardous nature, transport of 4-Nitroquinoline-1-Oxide requires careful handling and compliance with stringent safety regulations to ensure the safe delivery of the compound.
Upon procurement, 4-Nitroquinoline-1-Oxide is typically transported in secure, labeled containers to minimize the risk of exposure. The compound is often stored in controlled environments with proper ventilation and safety measures in place to prevent accidents and ensure the integrity of the product.
⚠️ Safety Considerations
Safety considerations for handling 4-Nitroquinoline-1-Oxide include the necessity of wearing appropriate personal protective equipment such as lab coats, safety glasses, and gloves to prevent skin contact and inhalation. It is crucial to work with this chemical in a well-ventilated area or under a fume hood to minimize exposure to its toxic fumes. Additionally, it is important to store 4-Nitroquinoline-1-Oxide in a tightly sealed container away from heat, sparks, and open flames to prevent the risk of fire or explosion.
The pharmacology of 4-Nitroquinoline-1-Oxide involves its ability to induce DNA damage and mutations in cells. This chemical is a potent mutagen and carcinogen, making it extremely hazardous to human health. Exposure to 4-Nitroquinoline-1-Oxide has been linked to an increased risk of cancer, particularly in the gastrointestinal tract. Therefore, strict safety measures should be followed when working with this compound to minimize the risk of adverse health effects.
Hazard statements for 4-Nitroquinoline-1-Oxide include “Causes skin irritation” and “May cause cancer.” This chemical is classified as a Category 2 carcinogen and should be handled with extreme caution to prevent harmful effects on human health. It is important to avoid direct contact with 4-Nitroquinoline-1-Oxide and to use appropriate protective measures to minimize exposure. In case of skin contact or ingestion, immediate medical attention should be sought to prevent further harm.
Precautionary statements for handling 4-Nitroquinoline-1-Oxide include “Avoid breathing dust/fume/gas/mist/vapors/spray” and “Wear protective gloves/protective clothing/eye protection/face protection.” It is essential to follow these precautions to reduce the risk of exposure to this hazardous chemical. Additionally, it is recommended to wash hands thoroughly after handling 4-Nitroquinoline-1-Oxide and to dispose of any contaminated clothing or equipment properly. Adherence to these precautionary measures is crucial to ensure the safety of individuals working with this compound.
🔬 Potential Research Directions
Potential research directions for 4-Nitroquinoline-1-Oxide include its role as a mutagen and carcinogen, particularly in studying its mechanisms of DNA damage and repair processes.
Further exploration into the pharmacological properties of 4-Nitroquinoline-1-Oxide may lead to the development of novel therapeutic interventions for cancer treatment.
Studies investigating the environmental impact and bioaccumulation potential of 4-Nitroquinoline-1-Oxide could provide valuable insights into its toxicity and persistence in ecosystems.
Future research could focus on the elucidation of the structure-activity relationships of 4-Nitroquinoline-1-Oxide analogues to optimize its biological activities and reduce its adverse effects.
🧪 Related Compounds
One similar compound to 4-Nitroquinoline-1-Oxide based upon molecular structure is 2-Nitroquinoline-1-Oxide. This compound differs from 4-Nitroquinoline-1-Oxide in the positioning of the nitro group on the quinoline ring. By having the nitro group at the 2-position instead of the 4-position, 2-Nitroquinoline-1-Oxide exhibits similar chemical properties and reactivity.
Another compound with a similar molecular structure to 4-Nitroquinoline-1-Oxide is 4-Nitroquinoline. This compound lacks the oxide functional group present in 4-Nitroquinoline-1-Oxide, but shares the same quinoline backbone with a nitro group attached at the 4-position. Both compounds are commonly used in research settings as mutagens and carcinogens, due to their ability to induce DNA damage.
Additionally, 4-Nitroquinoline is a closely related compound to 4-Nitroquinoline-1-Oxide. In this compound, the oxide functional group is replaced with a hydrogen atom, resulting in a simpler chemical structure. Like 4-Nitroquinoline-1-Oxide, 4-Nitroquinoline is known for its mutagenic and carcinogenic properties, making it a valuable tool in scientific studies related to DNA damage and repair mechanisms.
