4′-Nitroacetophenone is a chemical compound that holds significance in everyday life due to its applications in various industries. It is commonly used in the production of pharmaceuticals, fragrances, and dyes. Additionally, 4′-Nitroacetophenone is utilized in organic synthesis for the creation of new compounds with specific properties. Its versatility and importance in the manufacturing sector make it a relevant substance in our daily lives.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
4′-Nitroacetophenone is primarily utilized in commercial and industrial applications as a key intermediate in the synthesis of various pharmaceuticals, agrochemicals, and dyes. Its versatility and reactivity make it an important chemical building block for the production of a wide range of valuable compounds.
In the pharmaceutical industry, 4′-Nitroacetophenone is utilized in the synthesis of drugs such as antiviral agents, antibacterial agents, and anti-inflammatory drugs. Its unique chemical properties make it a valuable precursor for the development of potent and effective medications for various medical conditions.
Due to its ability to undergo diverse chemical reactions and form complex molecular structures, 4′-Nitroacetophenone plays a crucial role in the development of novel drug formulations and therapeutic agents. Its use in drug discovery and development highlights its importance in the pharmaceutical industry as a key chemical intermediate for the synthesis of life-saving medications.
⚗️ Chemical & Physical Properties
4′-Nitroacetophenone is a yellow crystalline powder with a faint odor. Its appearance is similar to that of powdered turmeric, and it has a slightly pungent smell that can be detected upon close inspection.
With a molar mass of 181.16 g/mol and a density of 1.32 g/cm³, 4′-Nitroacetophenone is heavier than common food items such as sugar (molar mass of 342.3 g/mol, density of 0.9 g/cm³) and salt (molar mass of 58.44 g/mol, density of 2.16 g/cm³).
4′-Nitroacetophenone has a melting point of approximately 75°C and a boiling point of around 292-294°C. These values are higher than those of common food items like butter (melting point of 32-35°C, boiling point of 130-150°C) and chocolate (melting point of 34-38°C, boiling point of 160-170°C).
In terms of solubility, 4′-Nitroacetophenone is slightly soluble in water and has a low viscosity. This differs from common food items like sugar and salt, which are highly soluble in water and have little to no viscosity when dissolved.
🏭 Production & Procurement
4′-Nitroacetophenone, also known as para-nitroacetophenone, is typically produced through a multi-step synthesis process. One common method involves the nitration of acetophenone using a mixture of nitric acid and sulfuric acid. The resulting product is then purified through recrystallization to obtain 4′-Nitroacetophenone in its solid form.
In terms of procurement and transportation, 4′-Nitroacetophenone can be purchased from chemical suppliers or manufacturers who specialize in producing fine chemicals. It is usually available in bulk quantities or smaller amounts for research purposes. When transporting 4′-Nitroacetophenone, it is important to adhere to proper safety measures and regulations due to its chemical properties.
Due to the potential hazards associated with handling 4′-Nitroacetophenone, it is important to ensure proper labeling and packaging when procuring and transporting the compound. It is recommended to store 4′-Nitroacetophenone in a cool, dry place away from direct sunlight and sources of heat. Additionally, it is advisable to use appropriate personal protective equipment when working with this compound to minimize the risk of exposure.
⚠️ Safety Considerations
Safety considerations for 4′-Nitroacetophenone include its potential to cause skin and eye irritation upon contact. It is also harmful if swallowed or inhaled, leading to respiratory irritation or even damage to internal organs. Proper personal protective equipment, such as gloves and goggles, should be worn when handling this compound to minimize the risk of exposure.
Hazard statements for 4′-Nitroacetophenone include “Causes skin and eye irritation” and “Harmful if swallowed or inhaled.” It is important to handle this compound with care to avoid any potential adverse effects on human health. Contaminated clothing should be removed immediately and washed before reuse to prevent further exposure.
Precautionary statements for 4′-Nitroacetophenone include “Wear protective gloves/eye protection/face protection” and “IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.” It is essential to follow proper safety protocols when working with this compound to minimize the risk of harm. In case of ingestion, seek medical advice immediately and provide the SDS or label to the healthcare professional.
🔬 Potential Research Directions
Potential research directions of 4′-Nitroacetophenone include investigating its potential as a building block in organic synthesis due to its versatile chemical properties. Researchers may also explore its potential applications in pharmaceuticals, agrochemicals, and material science. Additionally, studies focusing on the reaction mechanisms and catalytic processes involving 4′-Nitroacetophenone could lead to the development of novel chemical reactions and processes.
Another research direction could involve investigating the environmental impact of 4′-Nitroacetophenone and its derivatives, particularly in terms of toxicity and degradation pathways. Understanding how this compound interacts with the environment can aid in developing strategies for mitigating its potential harm. Furthermore, studies on the solubility, stability, and reactivity of 4′-Nitroacetophenone in various environmental conditions could provide valuable insights into its behavior in natural systems.
Researchers may also explore the bioactivity of 4′-Nitroacetophenone and its potential applications in medicinal chemistry. Investigations into its pharmacological properties, such as antimicrobial, anti-inflammatory, or anticancer activities, could lead to the development of new drug candidates. Additionally, studies on the structure-activity relationship of 4′-Nitroacetophenone analogs could help in optimizing its therapeutic potential and minimizing side effects.
Further research directions could involve exploring the synthesis of novel derivatives and analogs of 4′-Nitroacetophenone with tailored properties for specific applications. By modifying the chemical structure of 4′-Nitroacetophenone, researchers can fine-tune its reactivity, solubility, and bioactivity, leading to the development of new materials and compounds with enhanced properties. Additionally, studies on the properties of these derivatives could provide insights into structure-property relationships in organic chemistry.
🧪 Related Compounds
One similar compound to 4′-Nitroacetophenone is 4-Acetamidobenzaldehyde. This compound features a similar molecular structure with a substituted amide group instead of the nitro group found in 4′-Nitroacetophenone. The presence of the amide group provides different chemical properties and potential applications compared to 4′-Nitroacetophenone.
Another similar compound is 4′-Nitroacetophenone’s positional isomer, 2′-Nitroacetophenone. This compound shares the same molecular formula as 4′-Nitroacetophenone but with the nitro group located at a different position on the phenyl ring. Despite this difference in substitution position, 2′-Nitroacetophenone exhibits similar reactivity and properties to 4′-Nitroacetophenone due to the presence of the nitro group in the aromatic ring.
A further related compound is 4-Chloroacetophenone, which features a chlorine substituent instead of a nitro group. This compound maintains the acetophenone backbone but with a different halogen substitution. The presence of the chlorine group imparts distinct chemical properties and reactivity compared to 4′-Nitroacetophenone, leading to different potential applications in various chemical processes.
