4-Hydroxyquinoline is a compound that holds significance in various everyday applications. Its antiseptic properties make it a common ingredient in personal care products, such as soaps and lotions. Additionally, 4-Hydroxyquinoline is utilized in industrial processes as a corrosion inhibitor for metals and as a chelating agent in the production of rubber and textiles. Its diverse range of uses underscores the importance of this compound in supporting health, hygiene, and industrial operations in daily life.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
4-Hydroxyquinoline, also known as oxyquinoline, finds applications in various commercial and industrial sectors. It is commonly used as a chelating agent in the production of metal polishes, corrosion inhibitors, and textile dyeing processes. Additionally, 4-Hydroxyquinoline is utilized in the manufacturing of rubber chemicals, agricultural pesticides, and as a precursor in the synthesis of other heterocyclic compounds.
In the realm of drug and medication applications, 4-Hydroxyquinoline serves as a pharmaceutical intermediate for the synthesis of antimalarial and antimicrobial agents. Its potent antimicrobial properties make it a valuable ingredient in antiseptic solutions, wound care products, and topical creams for skin infections. Furthermore, 4-Hydroxyquinoline has demonstrated potential in the treatment of neurodegenerative disorders due to its ability to chelate metals and inhibit oxidative stress pathways.
⚗️ Chemical & Physical Properties
4-Hydroxyquinoline is a white to yellowish crystalline solid with a slight aromatic odor. It is commonly used as a chelating agent in chemical analysis and as an antiseptic in pharmaceuticals.
The molar mass of 4-Hydroxyquinoline is approximately 145.15 g/mol, with a density of around 1.16 g/cm³. Compared to common food items like sugar (molar mass of 342.30 g/mol, density of 1.59 g/cm³) and salt (molar mass of 58.44 g/mol, density of 2.16 g/cm³), 4-Hydroxyquinoline has a lower molar mass and density.
4-Hydroxyquinoline has a melting point of approximately 75-80°C and a boiling point of around 276-280°C. Compared to common food items like butter (melt around 32-35°C, boil around 250°C) and water (melt at 0°C, boil at 100°C), 4-Hydroxyquinoline has higher melting and boiling points.
4-Hydroxyquinoline is sparingly soluble in water, with a viscosity similar to that of water. Compared to common food items like sugar (highly soluble in water) and oil (insoluble in water, higher viscosity), 4-Hydroxyquinoline falls in between in terms of solubility and viscosity.
🏭 Production & Procurement
4-Hydroxyquinoline, a chemical compound commonly used in pharmaceuticals and industrial processes, is primarily produced through the reaction of aniline and para-formaldehyde in the presence of a catalyst. This process results in the formation of 4-Hydroxyquinoline as a white crystalline solid.
Once produced, 4-Hydroxyquinoline can be procured through chemical suppliers or manufacturers specializing in fine chemicals. It is typically packaged in sealed containers to prevent contamination and degradation during transportation. The compound can be transported via air, road, or sea freight depending on the quantity and destination.
For large-scale procurement of 4-Hydroxyquinoline, buyers may choose to work directly with manufacturers to ensure a stable and cost-effective supply chain. Quality control measures should be in place to guarantee the purity and consistency of the compound, particularly when it is intended for use in pharmaceutical formulations. Additionally, proper handling and storage protocols should be followed to maintain the integrity of 4-Hydroxyquinoline throughout the procurement process.
⚠️ Safety Considerations
Safety Considerations for 4-Hydroxyquinoline:
4-Hydroxyquinoline poses various safety considerations due to its potential hazards. The chemical is irritating to the eyes, skin, and respiratory system, and may cause skin sensitization. Ingestion or inhalation of 4-Hydroxyquinoline can lead to gastrointestinal irritation, nausea, vomiting, and respiratory discomfort.
In addition, 4-Hydroxyquinoline may be harmful if swallowed or inhaled in large quantities. The chemical can also be harmful to aquatic organisms. Proper precautions should be taken when handling 4-Hydroxyquinoline, including wearing appropriate personal protective equipment such as gloves, goggles, and a lab coat. It is important to work in a well-ventilated area and avoid contact with skin and eyes.
Hazard Statements for 4-Hydroxyquinoline:
Hazard statements for 4-Hydroxyquinoline include “Causes skin irritation,” “Causes serious eye irritation,” and “May cause respiratory irritation.” These statements indicate the potential dangers associated with exposure to the chemical, highlighting the need for caution when handling 4-Hydroxyquinoline. It is important to follow safety protocols and regulations to minimize the risk of harm.
Precautionary Statements for 4-Hydroxyquinoline:
Precautionary statements for 4-Hydroxyquinoline include “Wear protective gloves/eye protection/face protection,” “IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing,” and “Avoid breathing dust/fume/gas/mist/vapors/spray.” These statements emphasize the importance of implementing protective measures to reduce the potential risks associated with 4-Hydroxyquinoline exposure. Following these precautions can help maintain a safe working environment and prevent adverse health effects.
🔬 Potential Research Directions
1. 4-Hydroxyquinoline, also known as 4-Quinolinol, has shown promising antimicrobial activity against various pathogens, making it a prime candidate for further research in the field of antibiotic development.
2. Research on 4-Hydroxyquinoline has revealed its potential as a chelating agent for metal ions, suggesting its application in metal complexation studies and metal-based catalysts.
3. Investigations into the pharmacological properties of 4-Hydroxyquinoline have indicated its potential as a therapeutic agent in the treatment of neurodegenerative disorders, such as Alzheimer’s disease, due to its ability to chelate metal ions involved in disease progression.
4. The synthesis and structural modification of 4-Hydroxyquinoline derivatives may offer new avenues for drug discovery, particularly in the development of novel anti-cancer agents or compounds with improved pharmacokinetic profiles for various therapeutic applications.
🧪 Related Compounds
One similar compound to 4-Hydroxyquinoline is 8-hydroxyquinoline. This compound features a hydroxyl group attached to the eighth carbon atom in the quinoline ring structure. The presence of the hydroxyl group makes 8-hydroxyquinoline a versatile compound with various applications in chemistry and biochemistry.
Another compound similar to 4-Hydroxyquinoline is 5-hydroxyquinoline. In this compound, the hydroxyl group is attached to the fifth carbon atom of the quinoline ring. Similar to 4-Hydroxyquinoline, 5-hydroxyquinoline exhibits biological activity and has been investigated for its potential pharmaceutical applications. The structural similarity between these compounds allows for comparisons in their properties and reactivity.
Additionally, 2-hydroxyquinoline is a related compound to 4-Hydroxyquinoline. In this compound, the hydroxyl group is attached to the second carbon atom of the quinoline ring. Like other hydroxyquinolines, 2-hydroxyquinoline displays unique properties due to the presence of the hydroxyl group. The structural similarities between these compounds open up possibilities for exploring their reactivity and potential applications in various fields.
