4′-Hydroxyacetophenone, a compound commonly used in the pharmaceutical and cosmetic industries, holds significance in everyday life due to its various applications. As an ingredient in some over-the-counter medications, it plays a crucial role in providing relief from pain and inflammation. Additionally, 4′-Hydroxyacetophenone is utilized in skincare products for its antioxidant properties, helping to combat signs of aging and promote healthier skin. Overall, this compound’s presence in everyday products underscores its importance in enhancing health and well-being for consumers.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
4′-Hydroxyacetophenone, also known as p-hydroxyacetophenone, has various commercial and industrial applications due to its chemical properties. It is commonly used as a precursor in the synthesis of pharmaceuticals, perfumes, and agrochemicals. Additionally, it is utilized in the production of polymers, UV stabilizers, and antioxidants in the plastics industry.
In terms of drug and medication applications, 4′-Hydroxyacetophenone is often used as an intermediate in the synthesis of pharmaceutical compounds. It has been found to exhibit antioxidant and anti-inflammatory properties, making it a potential candidate for the development of novel drugs. Furthermore, this compound has shown promise in the treatment of neurological disorders and cancer due to its ability to modulate various cellular pathways.
⚗️ Chemical & Physical Properties
4′-Hydroxyacetophenone appears as a white crystalline solid with a slight odor. The odor is often described as faint and not overpowering, making it suitable for use in various applications.
The molar mass of 4′-Hydroxyacetophenone is approximately 136.15 g/mol, with a density of around 1.17 g/cm³. When compared to common food items, such as sugar or salt, 4′-Hydroxyacetophenone has a higher molar mass and slightly lower density.
4′-Hydroxyacetophenone has a melting point of around 114-117°C and a boiling point of approximately 302°C. These values differ significantly from common food items like butter or chocolate, which have lower melting and boiling points.
4′-Hydroxyacetophenone is sparingly soluble in water but highly soluble in organic solvents. It has a relatively low viscosity, making it easy to handle in liquid form. In comparison to common food items like flour or cornstarch, 4′-Hydroxyacetophenone exhibits lower solubility in water and a lower viscosity.
🏭 Production & Procurement
4′-Hydroxyacetophenone, a key intermediate in the synthesis of pharmaceuticals and other organic compounds, is typically produced through the Friedel-Crafts acylation reaction. In this process, acetophenone undergoes acylation with an acetylating agent in the presence of a Lewis acid catalyst to yield 4′-Hydroxyacetophenone. This method ensures high yields and purity of the final product.
Once produced, 4′-Hydroxyacetophenone can be procured from various chemical suppliers specializing in fine chemicals and intermediates for pharmaceutical applications. The compound is commonly available in both bulk quantities for industrial use and smaller quantities for research purposes. Suppliers often offer shipping options to transport 4′-Hydroxyacetophenone to customers worldwide, ensuring timely delivery and safe handling of the compound.
For transportation, 4′-Hydroxyacetophenone is typically packaged in suitable containers to prevent leakage and contamination during transit. Specialized chemical shipping companies may be utilized to transport the compound safely and efficiently, adhering to regulations governing the handling and transport of hazardous materials. Proper labeling and documentation are essential to ensure compliance with international protocols and regulations regarding the shipment of chemical substances.
⚠️ Safety Considerations
Safety considerations for 4′-Hydroxyacetophenone revolve around its potential hazards and risks associated with handling and storage. This chemical compound should be stored in a cool, dry, well-ventilated area away from heat, sparks, and open flames. Personal protective equipment, such as gloves, goggles, and lab coats, should be worn when handling 4′-Hydroxyacetophenone to minimize skin contact and inhalation of vapors. In case of accidental exposure, immediate first aid measures should be taken, and medical attention sought if necessary.
Hazard statements for 4′-Hydroxyacetophenone include “Causes skin irritation” and “Causes serious eye irritation.” These statements indicate the potential for skin and eye irritation upon contact with this chemical compound. It is important to handle 4′-Hydroxyacetophenone with caution and adhere to proper safety protocols to minimize the risk of skin and eye irritation.
Precautionary statements for 4′-Hydroxyacetophenone include “Wear protective gloves/eye protection” and “IF ON SKIN: Wash with plenty of soap and water.” These statements emphasize the importance of wearing appropriate personal protective equipment and practicing good hygiene when handling 4′-Hydroxyacetophenone to minimize the risk of skin and eye irritation. Adhering to these precautionary measures can help ensure safe handling and use of this chemical compound.
🔬 Potential Research Directions
One potential research direction for 4′-Hydroxyacetophenone is its use as a building block for the synthesis of complex organic molecules. This compound’s unique structure and reactivity make it a valuable starting material for the creation of new drug candidates or agrochemicals.
Another area of interest is exploring the biological activities of 4′-Hydroxyacetophenone and its derivatives. Studies have shown that this compound exhibits antioxidant properties and may have potential applications in the treatment of various diseases. Further research could uncover additional pharmacological activities and mechanisms of action.
Additionally, investigating the environmental fate and toxicity of 4′-Hydroxyacetophenone can provide valuable information for risk assessment and regulatory purposes. Understanding how this compound behaves in different environmental matrices and its potential impacts on ecosystems can guide decision-making in terms of its safe use and disposal.
Furthermore, exploring the potential industrial applications of 4′-Hydroxyacetophenone, such as its use as a flavoring agent or fragrance ingredient, could lead to the development of new products. The compound’s aromatic properties and chemical versatility make it a promising candidate for various applications in the cosmetic, food, and fragrance industries.
🧪 Related Compounds
One similar compound to 4′-Hydroxyacetophenone is 4′-Methoxyacetophenone. This compound has a similar molecular structure, with a methoxy group (-OCH3) in place of the hydroxy group (-OH) found in 4′-Hydroxyacetophenone. The presence of the methoxy group can lead to different chemical reactivity and biological properties compared to 4′-Hydroxyacetophenone.
Another similar compound is 4′-Nitroacetophenone. Like 4′-Hydroxyacetophenone, this compound contains a carbonyl group attached to a phenyl ring at the para position. However, in 4′-Nitroacetophenone, the hydroxy group is replaced with a nitro group (-NO2). This substitution can alter the compound’s physical and chemical properties, leading to differences in solubility, reactivity, and biological activities compared to 4′-Hydroxyacetophenone.
Additionally, 4′-Chloroacetophenone is another compound with a molecular structure similar to 4′-Hydroxyacetophenone. In this compound, the hydroxy group is substituted with a chlorine atom (-Cl). The presence of the chlorine atom can affect the compound’s reactivity and interactions with other molecules, resulting in differences in behavior compared to 4′-Hydroxyacetophenone.
