4-Aminophenylacetic acid, commonly known as PAA, is a chemical compound with various practical applications in everyday life. It is widely used in the pharmaceutical industry as a precursor to the production of medicines, such as certain antibiotics and analgesics. Additionally, PAA is utilized in the synthesis of dyes, perfumes, and other chemical products. Its presence in these diverse industries underscores its significance in modern society and highlights the compound’s relevance to everyday activities and products utilized by individuals worldwide.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
4-Aminophenylacetic acid, also known as APAA, has various commercial and industrial applications. It is commonly used as a precursor in the synthesis of pharmaceuticals, agrochemicals, and dyes. APAA is also used in the production of antioxidants, UV stabilizers, and corrosion inhibitors in the chemical industry.
In the realm of drug and medication applications, 4-Aminophenylacetic acid plays a crucial role. It is utilized as an intermediate in the synthesis of drugs such as non-steroidal anti-inflammatory drugs (NSAIDs) and histamine receptor antagonists. APAA is also incorporated into medications for the treatment of cardiovascular diseases and neurological disorders.
Moreover, in the pharmaceutical industry, 4-Aminophenylacetic acid is employed in the formation of peptides and chiral compounds. Its versatility and reactivity make it a valuable building block for the synthesis of various pharmaceutical products. Additionally, APAA is utilized in the preparation of chemical reagents and as a component in research and development activities for novel drug formulations.
⚗️ Chemical & Physical Properties
4-Aminophenylacetic acid, also known as para-aminophenylacetic acid, is a white crystalline solid with no distinctive odor.
With a molar mass of approximately 151.17 g/mol and a density of approximately 1.35 g/cm³, 4-Aminophenylacetic acid is heavier than most common food items, such as fruits and vegetables, which have lower molar masses and densities.
The melting point of 4-Aminophenylacetic acid is around 146°C, while its boiling point is around 345°C. These values are significantly higher than those of common food items, making 4-Aminophenylacetic acid more stable at higher temperatures.
4-Aminophenylacetic acid is moderately soluble in water and has a low viscosity. Compared to common food items, it has higher solubility and lower viscosity, making it easier to dissolve in water and less thick in consistency.
🏭 Production & Procurement
4-Aminophenylacetic acid, also known as APAA, is commonly produced through a multi-step chemical synthesis process. The first step involves the nitration of phenylacetic acid to form 4-nitrophenylacetic acid. The nitro group is then reduced to an amino group using reducing agents such as iron or hydrogen under specific conditions. Finally, the resulting product is purified through crystallization or chromatography to obtain pure APAA.
Procurement of 4-Aminophenylacetic acid can be done through various chemical suppliers or pharmaceutical companies that produce this compound. It is typically sold in bulk quantities or as a pure substance in solid form. The transportation of APAA is usually done in sealed containers to prevent any contamination or degradation during transit. Proper labeling and handling procedures are necessary to ensure the safe and secure delivery of the compound.
Different industries, including pharmaceutical, agricultural, and research sectors, use 4-Aminophenylacetic acid for various applications. The compound’s availability in the market allows for easy procurement by companies involved in the production of pharmaceuticals, agrochemicals, or research materials. Regulatory compliance and quality control measures are essential to guarantee the purity and consistency of the APAA obtained from suppliers.
⚠️ Safety Considerations
Safety Considerations for 4-Aminophenylacetic Acid:
4-Aminophenylacetic acid should be handled with caution as it is considered harmful if swallowed, inhaled, or in contact with skin. It may cause irritation to the respiratory system, skin, and eyes. Proper personal protective equipment, such as gloves and goggles, should be worn when handling this chemical. It should be stored in a cool, dry, well-ventilated area away from sources of heat or ignition to prevent accidental fires or explosions.
Hazard Statements for 4-Aminophenylacetic Acid:
Hazard statements associated with 4-Aminophenylacetic acid include “Causes skin irritation,” “Causes serious eye irritation,” and “May cause respiratory irritation.” In addition, it is stated that this chemical is harmful if swallowed, inhaled, or in contact with skin. These hazard statements highlight the potential dangers of exposure to 4-Aminophenylacetic acid and emphasize the need for proper precautions when handling it.
Precautionary Statements for 4-Aminophenylacetic Acid:
Precautionary statements for 4-Aminophenylacetic acid include “Wear protective gloves/protective clothing/eye protection/face protection” and “Wash hands thoroughly after handling.” It is also recommended to avoid breathing dust/fume/gas/mist/vapors/spray of this chemical. In case of skin irritation or rash, medical attention should be sought immediately. These precautionary statements aim to minimize the risks associated with 4-Aminophenylacetic acid exposure and protect the health and safety of individuals working with this chemical.
🔬 Potential Research Directions
One potential research direction for 4-Aminophenylacetic acid is its role in the synthesis of pharmaceutical compounds, as it has been identified as a precursor in the production of certain drugs. Further investigation into its chemical properties and reactions could contribute to the development of new therapeutic agents.
Another avenue of research could focus on the biological activities of 4-Aminophenylacetic acid, such as its potential as an anti-inflammatory or antioxidant agent. Studies exploring its effects on cellular processes and molecular pathways may uncover its therapeutic potential in treating various diseases.
Furthermore, investigations into the stability and degradation pathways of 4-Aminophenylacetic acid under different environmental conditions could provide insights into its storage and handling requirements in industrial settings. Understanding its chemical behavior could help optimize production processes and ensure the quality of end products.
Lastly, research into the environmental fate of 4-Aminophenylacetic acid, including its potential for bioaccumulation and ecological impact, could inform regulatory agencies on its safe use and disposal. Studies on its toxicity to aquatic organisms and its persistence in soil and water systems are important for assessing its environmental risks.
🧪 Related Compounds
One similar compound to 4-Aminophenylacetic acid based on molecular structure is 4-Aminophenylbutyric acid. In this compound, the phenyl group is attached to a butyric acid chain rather than an acetic acid chain. This variation in the side chain can lead to differences in solubility, reactivity, and biological activity compared to 4-Aminophenylacetic acid.
Another similar compound is 4-Aminophenylpropionic acid, where the phenyl group is attached to a propionic acid chain. This compound shares the same amino group on the phenyl ring as 4-Aminophenylacetic acid but has a longer carbon chain in its side chain. As a result, 4-Aminophenylpropionic acid may exhibit different chemical properties and biological activities compared to 4-Aminophenylacetic acid.
Additionally, 4-Aminophenylacetic acid can be compared to 4-Aminophenylmalonic acid, which has a malonic acid chain attached to the phenyl group. The presence of the malonic acid moiety can impact the acidity, stability, and binding properties of this compound in comparison to 4-Aminophenylacetic acid. These variations demonstrate the diversity of compounds that can be synthesized based on the molecular structure of 4-Aminophenylacetic acid.
