4-Amino-5-Hydroxymethyl-2-Methylpyrimidine, commonly known as AHPM, is a vital component in the production of thiamine, also known as vitamin B1. Thiamine plays a crucial role in converting the food we eat into the energy our bodies need to function properly. Without an adequate intake of thiamine, individuals may experience symptoms such as fatigue, muscle weakness, and nerve damage. Therefore, the availability of AHPM is essential for ensuring the proper functioning of our bodies and maintaining overall health and well-being.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
4-Amino-5-Hydroxymethyl-2-Methylpyrimidine, a compound primarily used in the pharmaceutical industry, has limited commercial and industrial applications outside of this sector. In pharmaceuticals, it serves as an intermediate in the synthesis of various drugs and medications, contributing to the development of important therapeutic agents.
With its unique chemical properties, 4-Amino-5-Hydroxymethyl-2-Methylpyrimidine plays a crucial role in the production of certain antiviral medications and antibiotics. This compound is utilized in the synthesis of key pharmaceutical ingredients, enabling the creation of effective treatments for a variety of medical conditions.
In the realm of drug development, 4-Amino-5-Hydroxymethyl-2-Methylpyrimidine is essential for the production of antifungal agents and medications targeting bacterial infections. Its chemical structure allows for the modification and enhancement of drug molecules, leading to the creation of potent pharmaceutical compounds with significant therapeutic benefits.
⚗️ Chemical & Physical Properties
4-Amino-5-Hydroxymethyl-2-Methylpyrimidine is a white crystalline powder that is odorless. Its appearance is similar to common household sugar or salt, but with a distinct chemical structure.
This compound has a molar mass of approximately 167.18 g/mol and a density of about 1.33 g/cm³. In comparison, common household items like table salt (NaCl) have molar mass of approximately 58.44 g/mol and a density of about 2.16 g/cm³, making 4-Amino-5-Hydroxymethyl-2-Methylpyrimidine denser.
The melting point of 4-Amino-5-Hydroxymethyl-2-Methylpyrimidine is around 202-204°C, while its boiling point is approximately 406.6°C at atmospheric pressure. These values are significantly higher than those of common household substances like sugar or salt, which have lower melting and boiling points.
4-Amino-5-Hydroxymethyl-2-Methylpyrimidine is sparingly soluble in water and exhibits low viscosity. This contrasts with common household items like sugar, which are highly soluble in water, and honey, which has a higher viscosity.
🏭 Production & Procurement
4-Amino-5-Hydroxymethyl-2-Methylpyrimidine is typically produced through a multistep synthesis method involving the reaction of starting materials such as 3-amino-2-chloropyridine and glyoxal with appropriate catalysts. This process may also involve various purification steps to obtain the final product in high purity.
The procurement of 4-Amino-5-Hydroxymethyl-2-Methylpyrimidine can be carried out through chemical suppliers who specialize in providing fine chemicals and intermediates to industries such as pharmaceuticals and agrochemicals. Upon procurement, the compound can be transported in sealed containers under controlled conditions to maintain its stability and purity.
Alternatively, some companies may choose to produce 4-Amino-5-Hydroxymethyl-2-Methylpyrimidine in-house using dedicated facilities equipped for the synthesis, purification, and handling of such chemical compounds. This approach allows for greater control over the production process and ensures consistent quality of the final product.
⚠️ Safety Considerations
Safety Considerations for 4-Amino-5-Hydroxymethyl-2-Methylpyrimidine:
When handling 4-Amino-5-Hydroxymethyl-2-Methylpyrimidine, it is essential to wear appropriate personal protective equipment such as gloves, goggles, and a lab coat to prevent skin and eye contact. In addition, this compound should be used in a well-ventilated area to minimize inhalation exposure. Proper storage in a tightly sealed container away from heat, sparks, and flames is also crucial to prevent fire hazards.
Pharmacology of 4-Amino-5-Hydroxymethyl-2-Methylpyrimidine:
4-Amino-5-Hydroxymethyl-2-Methylpyrimidine is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It acts as a precursor in the production of certain antiviral and antibacterial medications. This compound exhibits bioactivity by participating in key chemical reactions that lead to the formation of biologically active substances essential for therapeutic purposes.
Hazard Statements for 4-Amino-5-Hydroxymethyl-2-Methylpyrimidine:
The hazard statements associated with 4-Amino-5-Hydroxymethyl-2-Methylpyrimidine include “Causes skin irritation” and “May cause respiratory irritation.” These warnings indicate the potential for skin and respiratory tract discomfort upon exposure to this chemical. It is important to handle this compound with care and take necessary precautions to avoid direct contact with the skin or inhalation of vapors.
Precautionary Statements for 4-Amino-5-Hydroxymethyl-2-Methylpyrimidine:
To ensure safe handling of 4-Amino-5-Hydroxymethyl-2-Methylpyrimidine, it is recommended to wear protective gloves, clothing, eye protection, and respiratory mask. Avoid breathing in vapors and ensure adequate ventilation in the working area. In case of skin contact, immediately wash with soap and water, and seek medical attention if irritation persists. Proper disposal methods should be followed to prevent environmental contamination.
🔬 Potential Research Directions
Research on 4-Amino-5-Hydroxymethyl-2-Methylpyrimidine could focus on its potential pharmacological properties and therapeutic applications in various diseases, such as cancer and neurological disorders.
Exploration of the chemical synthesis and modification of 4-Amino-5-Hydroxymethyl-2-Methylpyrimidine could lead to the development of novel drug candidates with improved efficacy and reduced side effects.
Investigation into the molecular mechanisms underlying the biological activities of 4-Amino-5-Hydroxymethyl-2-Methylpyrimidine may provide valuable insights into its potential targets and pathways for drug development.
Studies on the pharmacokinetics and pharmacodynamics of 4-Amino-5-Hydroxymethyl-2-Methylpyrimidine could help optimize dosing regimens and improve therapeutic outcomes in clinical settings.
🧪 Related Compounds
One similar compound to 4-Amino-5-Hydroxymethyl-2-Methylpyrimidine is 4-Amino-5-Methyl-2-Hydroxymethylpyrimidine. This compound differs in the positioning of the methyl and hydroxymethyl groups on the pyrimidine ring, resulting in a variation in its properties and potential biological activities.
Another compound with a molecular structure akin to 4-Amino-5-Hydroxymethyl-2-Methylpyrimidine is 2-Methyl-4-Amino-5-Aminoxyacetylpyrimidine. In this compound, an Aminoxyacetyl group replaces the Hydroxymethyl group, leading to differences in its chemical reactivity and potential applications in medicinal chemistry.
Yet another compound sharing structural similarities with 4-Amino-5-Hydroxymethyl-2-Methylpyrimidine is 2,4-Diamino-5-Methylpyrimidine. This compound lacks the Hydroxymethyl group but retains the basic pyrimidine structure with amino and methyl substituents. Such structural analogs provide versatility in designing new molecules with varying biological activities.
