3,4-Dihydrocoumarin is a chemical compound commonly used in the fragrance industry due to its pleasant, sweet scent reminiscent of vanilla. This compound can be found in various perfumes, lotions, and other cosmetics, adding a luxurious and aromatic quality to everyday products. Additionally, 3,4-Dihydrocoumarin is used in the food industry as a flavoring agent, particularly in baked goods and confectionery items. Its widespread presence in consumer goods underscores its relevance to everyday life, enriching sensory experiences and enhancing the overall quality of products.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
In the realm of commercial and industrial applications, 3,4-Dihydrocoumarin is utilized as a fragrance ingredient in perfumes, cosmetics, and soaps. Its sweet, vanilla-like scent makes it a popular choice for adding a warm and comforting aroma to various products. Additionally, this compound is also employed in the food industry as a flavor enhancer, particularly in baked goods and beverages.
When it comes to drug and medication applications, 3,4-Dihydrocoumarin has been studied for its potential anti-inflammatory and antioxidant properties. Some research suggests that this compound may have therapeutic benefits in managing inflammation and oxidative stress-related conditions. Its ability to scavenge free radicals makes it a promising candidate for use in pharmaceutical formulations targeting various diseases.
⚗️ Chemical & Physical Properties
3,4-Dihydrocoumarin is a white crystalline solid that has a sweet, vanilla-like odor. It is commonly used in perfumes and flavorings due to its pleasant scent profile.
The molar mass of 3,4-Dihydrocoumarin is 146.14 g/mol, and its density is approximately 1.161 g/cm³. Compared to common household items, 3,4-Dihydrocoumarin is lighter in molar mass than salt (NaCl) but denser than water.
The melting point of 3,4-Dihydrocoumarin is around 113-116°C, while its boiling point is approximately 287-289°C. In comparison to common household items, 3,4-Dihydrocoumarin has a higher melting and boiling point than table sugar (sucrose) but lower than cooking oil.
3,4-Dihydrocoumarin is sparingly soluble in water and exhibits low viscosity. When compared to common household items, it is less soluble in water than salt (NaCl) and has lower viscosity than honey.
🏭 Production & Procurement
3,4-Dihydrocoumarin, a derivative of coumarin, can be produced through several methods. One common method involves the condensation of salicylaldehyde with ethyl or methyl acetoacetate, followed by intramolecular cyclization. Another method involves the reduction of coumarin with sodium in ethanol to yield 3,4-Dihydrocoumarin as a product.
Once synthesized, 3,4-Dihydrocoumarin can be procured from chemical suppliers, pharmaceutical companies, or research laboratories. It is typically transported in sealed containers to prevent degradation or contamination during transit. The compound is stable at room temperature but should be stored away from heat, light, and moisture to maintain its integrity.
For industrial purposes, large-scale production of 3,4-Dihydrocoumarin may involve the use of specialized equipment and procedures to ensure purity and yield. Quality control measures may be implemented to verify the identity and potency of the compound before distribution. Overall, the production and procurement of 3,4-Dihydrocoumarin require precision, attention to detail, and adherence to safety protocols.
⚠️ Safety Considerations
Safety considerations for 3,4-Dihydrocoumarin include potential skin and eye irritation upon contact. It is recommended to wear appropriate protective clothing, gloves, and goggles when handling this compound. In case of accidental ingestion, seek medical attention immediately and do not induce vomiting.
The pharmacology of 3,4-Dihydrocoumarin involves its ability to act as an anticoagulant and vasodilator. It has been studied for its potential therapeutic effects in cardiovascular diseases and as a possible treatment for thrombosis. However, more research is needed to fully understand its mechanism of action and potential side effects.
According to hazard statements, 3,4-Dihydrocoumarin may cause skin irritation and serious eye damage. It is also harmful if swallowed and may be toxic to aquatic life with long-lasting effects. It is important to handle this compound with care and avoid release into the environment to prevent negative impacts on both human health and the ecosystem.
Precautionary statements for 3,4-Dihydrocoumarin include avoiding breathing in dust/fume/gas/mist/vapors. In case of skin irritation, wash affected areas thoroughly with soap and water. If exposed to this compound, seek medical advice immediately and bring the product container or label for reference. Proper storage and disposal methods should also be followed to minimize risks associated with 3,4-Dihydrocoumarin.
🔬 Potential Research Directions
One potential research direction for 3,4-Dihydrocoumarin is its potential therapeutic applications, particularly in the field of medicine. Studies could investigate its potential use as a drug candidate for various diseases or conditions.
Another avenue for research on 3,4-Dihydrocoumarin could focus on its chemical properties and reactivity. Researchers could explore its potential as a building block for the synthesis of other compounds, or investigate its behavior under different conditions.
Furthermore, research on the biological activity of 3,4-Dihydrocoumarin could shed light on its potential as a bioactive compound. Studies could delve into its interactions with biological molecules or pathways, and its potential to modulate various cellular processes.
🧪 Related Compounds
3,4-Dihydrocoumarin is a compound with a molecular structure characterized by a benzene ring fused to a lactone ring. Similar compounds to 3,4-Dihydrocoumarin include benzopyrones such as 4-hydroxycoumarin, which differs in that it possesses a hydroxyl group in the 4-position rather than the 3-position. This substitution can lead to differences in biological activity and pharmacological properties.
Another compound related to 3,4-Dihydrocoumarin is Esculetin, which is a derivative of coumarin with a hydroxyl group in the 6-position. Esculetin has been found to exhibit antioxidant, anti-inflammatory, and anticancer properties. Its structural similarity to 3,4-Dihydrocoumarin allows for comparative studies of their respective biological activities and potential medicinal applications.
Additionally, Umbelliferone is another compound akin to 3,4-Dihydrocoumarin, possessing a benzene ring fused to a lactone ring. Umbelliferone is commonly found in certain plants and is known for its antioxidant and anti-inflammatory properties. Its structural resemblance to 3,4-Dihydrocoumarin highlights the importance of molecular structure in determining bioactivity and medicinal potential of compounds within the benzopyrone class.