3,4-dihydro-2H-pyran, also known as tetrahydropyran, is a compound that is commonly used in the field of organic chemistry. It serves as a building block for the synthesis of various important molecules, including pharmaceuticals, agrochemicals, and fragrances. In everyday life, these molecules play an essential role in the development of new medications, crop protection products, and perfumes that are widely used and valued by consumers. Therefore, the relevance of 3,4-dihydro-2H-pyran extends beyond the laboratory, as it contributes to the improvement of daily quality of life through its applications in various products and industries.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
3,4-dihydro-2H-pyran, a versatile compound, finds various commercial and industrial applications. It is commonly used as a flavoring agent in the food industry due to its sweet, fruity aroma. Additionally, it is utilized as a solvent in the production of adhesives, fragrances, and pharmaceuticals.
In terms of drug and medication applications, 3,4-dihydro-2H-pyran exhibits potential as a pharmaceutical intermediate in the synthesis of various drugs. It can be employed in the preparation of anti-inflammatory, antibacterial, and antifungal agents. Furthermore, it is studied for its potential use in the development of novel drug delivery systems.
Overall, 3,4-dihydro-2H-pyran demonstrates a wide range of practical applications in both commercial and industrial sectors, making it a valuable compound with numerous potential uses. Its versatility and unique properties continue to attract interest from researchers and industries seeking to explore its full potential.
⚗️ Chemical & Physical Properties
3,4-dihydro-2H-pyran is a colorless liquid with a pleasant, fruity odor. It has a molecular formula of C5H8O.
The molar mass of 3,4-dihydro-2H-pyran is approximately 84.12 g/mol, and its density is around 0.959 g/cm³. Compared to common food items such as sugar (molar mass around 342.3 g/mol) and water (density of 1 g/cm³), 3,4-dihydro-2H-pyran has a lower molar mass and density.
The melting point of 3,4-dihydro-2H-pyran is approximately -57°C, while the boiling point is around 88°C. In comparison, common food items like sugar have a much higher melting point (around 186°C) and water has a higher boiling point (100°C).
3,4-dihydro-2H-pyran is soluble in water and has a low viscosity. This makes it similar to common food items like salt and sugar, which are also water-soluble, but different from oils and fats, which have a higher viscosity and are not soluble in water.
🏭 Production & Procurement
3,4-dihydro-2H-pyran is primarily produced through the catalytic hydrogenation of 2,4-hexadienal. This reaction typically takes place in the presence of a hydrogenation catalyst such as palladium on carbon at elevated temperatures and pressures. The resulting product is then purified through various distillation and extraction methods to obtain high purity 3,4-dihydro-2H-pyran.
The procurement of 3,4-dihydro-2H-pyran can be achieved through a variety of commercial chemical suppliers. Large quantities of the compound are often shipped in sealed containers to prevent contamination or degradation during transport. Due to the compound’s flammability and potential reactivity, proper safety precautions must be taken when procuring and handling 3,4-dihydro-2H-pyran.
After procurement, 3,4-dihydro-2H-pyran can be stored in a cool, dry place away from direct sunlight and heat sources. Proper labeling and handling instructions should be followed to ensure the compound’s stability and integrity. When transporting 3,4-dihydro-2H-pyran, it is important to comply with all relevant regulations and guidelines to prevent any accidental spills or leaks that could pose a risk to human health and the environment.
⚠️ Safety Considerations
Safety considerations for handling 3,4-dihydro-2H-pyran include its flammable nature, presenting a fire hazard in the presence of ignition sources. It should be stored in a cool, well-ventilated area away from heat, sparks, and flames. Personal protective equipment such as gloves, goggles, and lab coats should be worn when handling this chemical to prevent skin contact and inhalation of vapors.
Hazard statements associated with 3,4-dihydro-2H-pyran include “Highly flammable liquid and vapor,” “Causes skin irritation,” and “Causes serious eye irritation.” It is also noted as potentially harmful if swallowed or inhaled. These hazard statements underline the importance of proper precautions when working with this compound to avoid adverse health effects.
Precautionary statements for handling 3,4-dihydro-2H-pyran include avoiding breathing vapors, wearing protective gloves and eye/face protection, and keeping away from heat, sparks, and open flames. It is advised to use explosion-proof equipment and ensure adequate ventilation when working with this chemical. In case of skin contact, it is recommended to wash thoroughly with soap and water, and in case of eye contact, to rinse cautiously with water for several minutes while removing contact lenses.
🔬 Potential Research Directions
One potential research direction for 3,4-dihydro-2H-pyran is its use as a building block in organic synthesis. This compound’s unique structure and reactivity make it a valuable starting material for the synthesis of various biologically active molecules and natural products.
Another promising avenue of research involves exploring the biological activities of 3,4-dihydro-2H-pyran and its derivatives. Investigating the potential pharmacological properties of this compound could lead to the development of new drug candidates for various diseases, such as cancer, infectious diseases, and neurological disorders.
Furthermore, studies on the environmental fate and toxicity of 3,4-dihydro-2H-pyran are essential for understanding its impact on ecosystems and human health. Conducting research on the environmental behavior of this compound can help in designing safer and more sustainable chemical processes and products.
🧪 Related Compounds
One similar compound to 3,4-dihydro-2H-pyran is tetrahydropyran. Tetrahydropyran shares a similar molecular structure with 3,4-dihydro-2H-pyran, as it is a cyclic ether with four carbon atoms and one oxygen atom. However, tetrahydropyran differs in the position of the double bond and the presence of an additional hydrogen atom in the ring.
Another similar compound to 3,4-dihydro-2H-pyran is furan. Furan is a heterocyclic compound with a five-membered ring containing four carbon atoms and one oxygen atom. Like 3,4-dihydro-2H-pyran, furan is a cyclic ether with a double bond between two carbon atoms. However, furan differs in its ring size and structure, making it a related but distinct compound.
One more related compound to 3,4-dihydro-2H-pyran is dihydropyran. Dihydropyran is a six-membered cyclic ether with five carbon atoms and one oxygen atom. It shares similarities with 3,4-dihydro-2H-pyran in terms of the presence of a double bond and the cyclic nature of the molecule. However, dihydropyran differs in its ring size and substitution pattern, making it a closely related compound with some structural differences.
