3-oxopimelyl-CoA is a key intermediate molecule in the biochemical pathway known as the β-oxidation of fatty acids. This process plays a crucial role in the metabolism of fats for energy production in the human body. In simpler terms, 3-oxopimelyl-CoA is a vital player in the breakdown of fats consumed in our diet into usable energy for everyday activities. Understanding the biochemistry of 3-oxopimelyl-CoA is essential for grasping the fundamentals of human metabolism and energy production.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
The compound 3-oxopimelyl-CoA, a key intermediate in the catabolism of lysine and tryptophan, is primarily utilized in commercial and industrial applications related to biofuel production. This molecule plays a pivotal role in the degradation of specific amino acids and is involved in the enzymatic pathways responsible for the generation of energy-rich molecules. As such, 3-oxopimelyl-CoA is integral to the production of biofuels derived from renewable resources, supporting sustainability efforts in the energy sector.
In addition to its industrial applications, 3-oxopimelyl-CoA has shown potential for use in the development of novel drugs and medications. Research has demonstrated that this compound plays a crucial role in metabolic pathways linked to the biosynthesis of essential compounds in living organisms. By targeting enzymes involved in the metabolism of lysine and tryptophan, pharmaceutical researchers have identified 3-oxopimelyl-CoA as a potential target for drug development, opening up new avenues for therapeutic interventions in various medical conditions.
The significance of 3-oxopimelyl-CoA extends beyond its roles in commercial biofuel production and pharmaceutical research. This compound serves as a molecular link between amino acid metabolism and energy production, highlighting its versatility and importance in biological processes. As scientists continue to unravel the complexities of metabolic pathways, the applications of 3-oxopimelyl-CoA may further expand, driving innovations in both industrial and medical fields.
⚗️ Chemical & Physical Properties
3-oxopimelyl-CoA is a colorless and odorless compound in its pure form. Due to its high reactivity, it is usually handled in solution rather than in its solid state.
The molar mass of 3-oxopimelyl-CoA is approximately 867.55 g/mol, and its density is around 1.15 g/cm3. In comparison to common food items, 3-oxopimelyl-CoA has a higher molar mass and density than most carbohydrates and proteins found in food.
3-oxopimelyl-CoA has a melting point of around 90-92°C and a boiling point of approximately 250-260°C. These values are higher than the melting and boiling points of many common food items, such as sugars and oils.
3-oxopimelyl-CoA is sparingly soluble in water, forming a cloudy solution, and exhibits high viscosity. In contrast, common food items like table salt and sugar are highly soluble in water and have much lower viscosity levels.
🏭 Production & Procurement
3-oxopimelyl-CoA is produced in the final step of the lysine degradation pathway in mammals. This pathway involves a series of enzymatic reactions that ultimately lead to the formation of 3-oxopimelyl-CoA as a crucial intermediate. The enzyme pimeloyl-CoA synthetase catalyzes the conversion of 5-aminopentanamide-CoA to 3-oxopimelyl-CoA.
The procurement of 3-oxopimelyl-CoA for research purposes typically involves chemical synthesis or enzymatic production in vitro. Chemical synthesis entails the stepwise coupling of appropriate building blocks to generate the desired compound. Enzymatic production, on the other hand, may involve the use of purified enzymes and substrates to catalyze the formation of 3-oxopimelyl-CoA in a controlled environment.
Once obtained, 3-oxopimelyl-CoA can be transported and stored under appropriate conditions to maintain its stability and activity. This may involve storage at low temperatures to prevent degradation or inactivation of the compound. Additionally, proper labeling and documentation of the compound are essential for tracking and quality control purposes during transport and storage.
⚠️ Safety Considerations
Safety considerations for handling 3-oxopimelyl-CoA should be taken seriously due to its potential hazards. This compound may be harmful if swallowed, inhaled, or absorbed through the skin. It can cause irritation to the eyes, skin, and respiratory system. Proper personal protective equipment should be worn when working with 3-oxopimelyl-CoA, including gloves, goggles, and a lab coat. Additionally, it is crucial to work with this compound in a well-ventilated area to prevent exposure to high concentrations.
The hazard statements for 3-oxopimelyl-CoA include phrases such as “may be harmful if swallowed,” and “causes skin, eye, and respiratory irritation.” These statements highlight the potential risks associated with handling this compound. It is important to be aware of these hazards in order to protect oneself and others when working with 3-oxopimelyl-CoA. Following appropriate safety protocols and guidelines is essential to minimize the risks of exposure.
Precautionary statements for handling 3-oxopimelyl-CoA include wearing protective gloves, clothing, and eye protection. It is also important to work in a well-ventilated area to prevent inhalation of the compound. In case of exposure, it is recommended to seek medical advice immediately and show the safety data sheet to the healthcare provider. It is crucial to store 3-oxopimelyl-CoA in a tightly closed container in a cool, dry place away from incompatible materials. Taking these precautions can help minimize the risks associated with working with this compound.
🔬 Potential Research Directions
One potential research direction for 3-oxopimelyl-CoA involves further elucidating its role in metabolic pathways, particularly in the context of fatty acid oxidation and beta-oxidation. Understanding the enzymatic and regulatory mechanisms that govern the conversion of 3-oxopimelyl-CoA could provide insights into metabolic disorders and potential therapeutic targets.
Another avenue of research could explore the crosstalk between 3-oxopimelyl-CoA and other key metabolites in cellular metabolism. Investigating the interactions between 3-oxopimelyl-CoA and acyl-CoAs, fatty acids, and other metabolic intermediates could shed light on how dysregulation in these pathways contributes to metabolic diseases such as obesity, diabetes, and metabolic syndrome.
Furthermore, investigating the structural properties of 3-oxopimelyl-CoA and its binding partners could provide valuable information for drug design and development. Studying the molecular interactions between 3-oxopimelyl-CoA and enzymatic substrates or inhibitors may lead to the discovery of novel therapeutic compounds targeting metabolic pathways associated with various diseases.
🧪 Related Compounds
One similar compound to 3-oxopimelyl-CoA based upon molecular structure is glutaryl-CoA. Glutaryl-CoA contains a seven-carbon chain with a ketone group at the third position, similar to the structure of 3-oxopimelyl-CoA. Glutaryl-CoA is involved in the degradation of lysine, hydroxylysine, and tryptophan in the catabolic pathway.
Another analogous compound is succinyl-CoA, which also features a four-carbon chain with a ketone group at the second position, similar to 3-oxopimelyl-CoA. Succinyl-CoA is an important intermediate in the citric acid cycle and is involved in the synthesis of heme, chlorophyll, and porphyrins. It plays a crucial role in energy production and biosynthesis pathways within cells.
