3-Nitroanisole is a compound that has relevance to everyday life due to its utilization in the production of various consumer goods. This chemical substance is often employed in the manufacturing of perfumes, flavorings, and pharmaceuticals. Its presence in these products enhances their aroma and taste, making them more appealing to consumers. Additionally, 3-Nitroanisole has applications in the field of organic synthesis, playing a key role in the creation of important pharmaceutical drugs. Therefore, the significance of this compound extends beyond the realm of scientific research, impacting the quality and functionality of the products that individuals interact with on a daily basis.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
3-Nitroanisole, also known as m-anisidinenitrobenzene, has various commercial and industrial applications. This chemical compound is commonly used as an intermediate in the synthesis of pharmaceuticals, dyes, and agrochemicals. It is also employed as a precursor in the production of antioxidants and fragrances due to its versatile reactivity and functional groups.
In the pharmaceutical industry, 3-Nitroanisole is utilized as a building block in the synthesis of various drugs and medications. It serves as a key intermediate in the production of analgesics, antipyretics, and anti-inflammatory drugs. Additionally, this compound is an essential component in the creation of anticancer drugs and other therapeutic agents.
Furthermore, 3-Nitroanisole has been found to possess potential biological activities that make it a valuable compound in drug discovery and development. Its unique chemical properties make it a promising candidate for the design of novel pharmaceuticals with improved efficacy and reduced side effects. Researchers continue to explore the diverse applications of 3-Nitroanisole in the field of medicine and drug development.
⚗️ Chemical & Physical Properties
3-Nitroanisole is a pale yellow solid with a distinct odor. Its smell is described as sweet and floral, reminiscent of anise or licorice.
The molar mass of 3-Nitroanisole is approximately 153.13 g/mol, with a density of about 1.22 g/cm³. This places it in a similar range to common food items like sugar (molar mass of 342.3 g/mol, density of 1.59 g/cm³) and salt (molar mass of 58.44 g/mol, density of 2.165 g/cm³).
The melting point of 3-Nitroanisole is around 59-61°C, while the boiling point is approximately 285-287°C. These values are significantly higher than those of common food items like butter (melting point of 32-35°C) and water (boiling point of 100°C), indicating its more robust thermal properties.
3-Nitroanisole is sparingly soluble in water and exhibits a low viscosity. Compared to common food items like sugar (high solubility in water) and honey (high viscosity), 3-Nitroanisole offers contrasting characteristics in terms of solubility and viscosity.
🏭 Production & Procurement
3-Nitroanisole is produced through the nitration of anisole, which involves the reaction of anisole with a mixture of nitric acid and sulfuric acid at a controlled temperature. This process results in the substitution of a nitro group (-NO2) at the para position of the anisole molecule, yielding 3-Nitroanisole as the final product.
3-Nitroanisole can be procured from chemical suppliers that specialize in aromatic compounds and intermediates. It is typically available in the form of a solid or liquid, depending on the specific manufacturing process used by the supplier. Transportation of 3-Nitroanisole is conducted in accordance with regulations governing the handling of hazardous chemicals, utilizing appropriate packaging and labeling to ensure safe delivery.
Upon procurement, 3-Nitroanisole may be shipped in various quantities, ranging from small vials to larger drums or containers, depending on the intended applications of the compound. Transportation methods for 3-Nitroanisole include ground shipping, air freight, or sea transport, with consideration given to factors such as stability, temperature sensitivity, and regulatory requirements for hazardous materials.
⚠️ Safety Considerations
Safety considerations for 3-Nitroanisole include its potential to cause skin and eye irritation upon contact. When handling this chemical, it is important to wear appropriate personal protective equipment such as gloves, safety goggles, and a lab coat to minimize the risk of exposure. Additionally, proper ventilation should be maintained in the work area to prevent inhalation of vapors or dust particles.
It is advisable to store 3-Nitroanisole in a cool, dry, well-ventilated area away from incompatible materials such as strong oxidizing agents. Care should be taken to prevent spills or leaks, as the chemical may pose a fire hazard. In the event of a spill, absorbent material should be used to contain and clean up the substance, while contaminated clothing should be removed immediately and washed before reuse. Proper waste disposal procedures should be followed to prevent environmental contamination.
The hazard statements for 3-Nitroanisole include “Causes skin irritation” and “Causes serious eye irritation.” These statements indicate the potential for the chemical to cause harm upon contact with the skin or eyes. It is important to take appropriate precautions when handling 3-Nitroanisole to minimize the risk of skin or eye irritation, such as wearing protective gloves and safety goggles.
Precautionary statements for 3-Nitroanisole include “Wear protective gloves/eye protection” and “IF ON SKIN: Wash with plenty of soap and water.” These statements advise individuals on the necessary precautions to take when working with the chemical to ensure their safety. By following these precautionary measures, the risk of exposure to 3-Nitroanisole can be minimized, reducing the likelihood of adverse health effects.
🔬 Potential Research Directions
One potential research direction for 3-Nitroanisole lies in exploring its use as a precursor in the synthesis of various organic compounds, particularly in the pharmaceutical and agrochemical industries. By investigating its reactivity with different functional groups, researchers can uncover new pathways for the efficient production of valuable molecules.
Another avenue of study could involve investigating the environmental impact of 3-Nitroanisole, particularly its potential for bioaccumulation in ecosystems. Understanding the fate and behavior of this compound in soil, water, and air could provide important insights into its potential risks to human health and the environment.
Furthermore, research on the toxicological effects of 3-Nitroanisole on living organisms could lead to valuable information on its potential hazards and risks. By conducting studies on its mutagenicity, carcinogenicity, and other toxic properties, researchers can provide valuable data for regulatory agencies and industry stakeholders to make informed decisions on its safe handling and disposal.
🧪 Related Compounds
One similar compound to 3-Nitroanisole based upon molecular structure is 4-Nitroanisole. This compound also contains a nitro group attached to an anisole structure, but in this case the nitro group is positioned at the para position relative to the methoxy group. This subtle difference results in distinct chemical properties and reactivity compared to 3-Nitroanisole.
Another analogous compound is 2-Nitroanisole, which features a nitro group attached to an anisole structure at the ortho position relative to the methoxy group. This positioning of the nitro group alters the steric and electronic effects on the molecule, leading to differences in its physical and chemical properties compared to 3-Nitroanisole. The varying positions of the nitro group in these compounds demonstrate the structural diversity within the nitroanisole family.
Additionally, 3-Nitrophenol is a compound similar to 3-Nitroanisole in terms of molecular structure. Both molecules contain a nitro group attached to a phenolic ring, but 3-Nitrophenol lacks the methoxy substituent present in 3-Nitroanisole. This structural variance results in differing chemical reactivity and properties between the two compounds, highlighting the importance of subtle structural modifications in determining compound behavior.
