3-Hydroxyphenylacetic acid, a compound known for its antimicrobial properties, has relevance in everyday life due to its potential applications in various industries. This compound has been studied for its potential use in pharmaceuticals, cosmetics, and food products as a natural preservative. Additionally, research has shown that 3-Hydroxyphenylacetic acid may have anti-inflammatory and antioxidant properties, making it a valuable ingredient in health and wellness products. Its diverse range of potential uses highlights its importance in everyday life and ongoing research into its various benefits.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
3-Hydroxyphenylacetic acid, also known as m-Hydroxyphenylacetic acid, has several commercial and industrial applications. It is commonly used as a precursor in the synthesis of various pharmaceuticals, agrochemicals, and dyes due to its versatile chemical properties. Additionally, it is utilized in the production of fragrances and flavoring agents in the food and beverage industry.
In the field of drug development and medication, 3-Hydroxyphenylacetic acid plays a crucial role as a building block in the synthesis of drug molecules with therapeutic properties. It is often incorporated into the structure of pharmaceuticals to enhance their bioavailability and efficacy. Moreover, this compound has shown potential as a chiral auxiliary in asymmetric synthesis, making it valuable in the production of enantiopure drugs with improved pharmacological profiles.
Overall, the commercial and industrial applications of 3-Hydroxyphenylacetic acid are diverse and significant in various sectors. Its role as a key intermediate in the synthesis of pharmaceuticals, agrochemicals, dyes, fragrances, and flavoring agents underscores its importance in modern chemical and pharmaceutical industries. Additionally, its utility in drug development and medication highlights its potential for contributing to advances in healthcare and medicine.
⚗️ Chemical & Physical Properties
3-Hydroxyphenylacetic acid appears as a white crystalline solid with a faint odor. It is usually found in a powdered form.
The molar mass of 3-Hydroxyphenylacetic acid is approximately 152.15 g/mol, with a density of around 1.344 g/cm³. This molar mass is comparable to common household items such as baking soda, while the density is similar to that of table salt.
The melting point of 3-Hydroxyphenylacetic acid is around 158-160°C, while the boiling point is approximately 350-352°C. These values are higher than those of common household items like sugar and butter.
3-Hydroxyphenylacetic acid is slightly soluble in water and has a relatively low viscosity. Its solubility in water is comparable to that of Epsom salt, while the viscosity is similar to that of vinegar.
🏭 Production & Procurement
3-Hydroxyphenylacetic acid is commonly produced through a chemical reaction involving the hydrolysis of 3-chloro-4-hydroxyphenylacetic acid. This reaction typically occurs in the presence of a strong base and results in the formation of 3-Hydroxyphenylacetic acid as a crystalline solid.
The procurement of 3-Hydroxyphenylacetic acid can be achieved through various means, including direct purchase from chemical suppliers or synthesis in a laboratory setting. Once procured, the compound can be transported in solid form in sealed containers to ensure its stability and prevent contamination during transit.
It is important to note that proper handling and storage of 3-Hydroxyphenylacetic acid is essential to maintain its integrity and purity. Special care should be taken to protect the compound from exposure to light, moisture, and extreme temperatures in order to preserve its chemical properties.
⚠️ Safety Considerations
Safety considerations for 3-Hydroxyphenylacetic acid include proper storage and handling to prevent potential hazards. It is important to store the chemical in a cool, dry place away from direct sunlight and moisture. When handling 3-Hydroxyphenylacetic acid, it is recommended to wear appropriate personal protective equipment, such as gloves and safety goggles, to avoid skin contact and inhalation of vapors.
In terms of pharmacology, 3-Hydroxyphenylacetic acid is known to act as a metabolite of dopamine and norepinephrine in the brain. It plays a role in the regulation of neurotransmitter levels and is involved in various physiological processes, including mood regulation and stress response. The compound has been studied for its potential therapeutic effects on mood disorders and neurological conditions.
Hazard statements for 3-Hydroxyphenylacetic acid include its potential to cause skin irritation, eye irritation, and respiratory irritation upon contact or inhalation. It is also classified as harmful if swallowed or inhaled, and may cause damage to organs through prolonged or repeated exposure. In case of exposure, immediate medical attention is advised, and contaminated clothing should be removed and washed before reuse.
Precautionary statements for 3-Hydroxyphenylacetic acid include avoiding direct contact with skin, eyes, and clothing, as well as avoiding inhalation of vapors or dust. It is important to work with the compound in a well-ventilated area or under a fume hood to minimize exposure. In case of accidental exposure, it is recommended to rinse affected areas with water and seek medical advice if irritation persists. Additionally, proper disposal methods should be followed to prevent environmental contamination.
🔬 Potential Research Directions
One potential research direction for 3-Hydroxyphenylacetic acid is its role as a precursor in the biosynthesis of key molecules such as catecholamines and thyroid hormones. Understanding the exact mechanisms by which this compound contributes to these pathways could provide insights into various physiological processes.
Another area of interest is the potential pharmacological properties of 3-Hydroxyphenylacetic acid, particularly its antioxidant and anti-inflammatory effects. Exploring the bioactivity of this compound could lead to the development of novel therapeutic agents for conditions characterized by oxidative stress and inflammation.
Furthermore, studies investigating the metabolism and excretion of 3-Hydroxyphenylacetic acid could provide valuable information on its pharmacokinetics and potential toxicological implications. Determining the fate of this compound in the body could help in assessing its safety profile and optimizing dosing regimens for potential therapeutic applications.
🧪 Related Compounds
One similar compound to 3-Hydroxyphenylacetic acid is 3-Hydroxybenzoic acid. This compound has a similar molecular structure, with a hydroxyl group attached to a benzene ring at the 3-position. Additionally, both compounds belong to the class of phenolic acids, which are widely found in various natural sources such as plants, fruits, and vegetables.
Another related compound is 4-Hydroxyphenylacetic acid. In this compound, the hydroxyl group is attached to the benzene ring at the 4-position instead of the 3-position as in 3-Hydroxyphenylacetic acid. Despite this difference in positioning, both compounds share similar chemical properties due to the presence of the hydroxyl group attached to the aromatic ring.
Furthermore, Vanillic acid is another compound that bears similarities to 3-Hydroxyphenylacetic acid. Vanillic acid is a derivative of vanillin, a common flavoring agent used in foods and beverages. Like 3-Hydroxyphenylacetic acid, Vanillic acid contains a hydroxyl group attached to a benzene ring, albeit with an additional methoxy group attached to the para position. This structural similarity allows for similar interactions and reactivities in various chemical and biological processes.
