3-Fluoroaniline is a chemical compound that holds significance in everyday life due to its role in the production of various pharmaceuticals, agrochemicals, and dyes. This compound is commonly utilized in the synthesis of drugs such as lurasidone and rilpivirine, which are used in the treatment of mental health disorders and HIV, respectively. Additionally, 3-Fluoroaniline is employed in the manufacturing of plant protection products and pigments, making it a versatile component in several industries. Its presence in everyday products highlights the importance of this compound in modern society.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
3-Fluoroaniline, also known as m-fluoroaniline, is a derivative of aniline with the chemical formula C6H6FN. It finds commercial and industrial applications in the production of dyes, pharmaceuticals, and agrochemicals. Its ability to undergo various chemical reactions, such as diazotization and coupling reactions, makes it a valuable intermediate in organic synthesis.
In the pharmaceutical industry, 3-fluoroaniline is used as a building block in the synthesis of pharmaceutical drugs and medications. It plays a crucial role in the manufacture of certain antimalarial and antibacterial agents. Its versatile reactivity enables chemists to introduce the fluoro substituent into complex molecular structures, enhancing the desired biological activity of the final products.
The unique properties of 3-fluoroaniline make it a versatile compound with diverse applications in both commercial and industrial sectors. Its structural features and chemical reactivity have positioned it as a valuable tool in the development of various products, ranging from dyes and agrochemicals to pharmaceutical drugs and medications. The significance of 3-fluoroaniline in organic synthesis underscores its importance in advancing scientific research and technological innovations.
⚗️ Chemical & Physical Properties
3-Fluoroaniline appears as a colorless to pale yellow liquid with a strong odor that is similar to aniline. It is a derivative of aniline with a fluorine atom attached to the benzene ring.
The molar mass of 3-Fluoroaniline is approximately 111.1 g/mol, with a density of about 1.19 g/cm³. In comparison to common food items, 3-Fluoroaniline has a higher molar mass and density than water, salt, and sugar.
The melting point of 3-Fluoroaniline is around -6.7°C, while the boiling point is approximately 195°C. Compared to common food items such as butter, chocolate, and honey, 3-Fluoroaniline has a higher melting point and boiling point.
3-Fluoroaniline is sparingly soluble in water, but moderately soluble in organic solvents. It has a low viscosity, making it flow easily. In contrast, common food items like salt and sugar are highly soluble in water and have varying viscosities depending on their concentrations.
🏭 Production & Procurement
3-Fluoroaniline is produced through a process known as nucleophilic aromatic substitution. This involves the reaction of fluorobenzene with ammonia in the presence of a catalyst to yield 3-Fluoroaniline as the final product. The reaction typically takes place under heating conditions to facilitate the substitution process.
3-Fluoroaniline can be procured from chemical suppliers specializing in aromatic compounds. It is commonly available in various purities and quantities depending on the intended application. The compound is typically shipped in sealed containers to prevent exposure to moisture or other contaminants during transportation.
When transporting 3-Fluoroaniline, proper handling procedures must be followed to ensure safety and prevent spills. The compound is classified as a hazardous material due to its toxic and flammable nature. As such, regulations regarding the transport of hazardous chemicals must be strictly adhered to in order to mitigate the risk of accidents or exposure during transit.
⚠️ Safety Considerations
Safety considerations for 3-Fluoroaniline should be taken seriously due to its toxicity and potential health hazards. Exposure to this chemical can result in irritation of the skin, eyes, and respiratory system. It is also classified as a possible carcinogen, meaning it may cause cancer with prolonged or high levels of exposure. Proper personal protective equipment, such as gloves and goggles, should be worn when handling 3-Fluoroaniline to minimize the risk of exposure.
Hazard statements for 3-Fluoroaniline include “Causes skin irritation,” “Causes serious eye irritation,” and “May cause cancer.” These statements indicate the potential dangers associated with exposure to this chemical. It is important to handle 3-Fluoroaniline with caution and to follow proper safety protocols to minimize the risks of skin and eye irritation, as well as the potential long-term health effects such as cancer.
Precautionary statements for 3-Fluoroaniline include “Avoid breathing dust/fume/gas/mist/vapors/spray,” “Use personal protective equipment as required,” and “IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.” These statements emphasize the importance of avoiding inhalation of the chemical, using appropriate protective gear, and following proper procedures in case of accidental exposure. It is crucial to adhere to these precautions to ensure the safety of individuals working with 3-Fluoroaniline.
🔬 Potential Research Directions
Research on 3-Fluoroaniline could explore its potential applications in the field of pharmaceuticals, specifically investigating its role as a building block for the synthesis of complex molecules with biological activity.
Furthermore, studies could investigate the environmental impact of 3-Fluoroaniline, focusing on its persistence in the environment, potential toxicity to aquatic organisms, and the development of methods for its removal from contaminated water sources.
Additionally, research could be conducted to elucidate the mechanistic pathways of reactions involving 3-Fluoroaniline, aiming to deepen our understanding of its reactivity and potential for selective functionalization in organic synthesis.
🧪 Related Compounds
One similar compound to 3-Fluoroaniline is 2-Fluoroaniline, which contains a fluorine atom in the para position to the amino group. This compound is structurally similar to 3-Fluoroaniline, with the difference being the position of the fluorine atom on the benzene ring. 2-Fluoroaniline also exhibits similar chemical properties to 3-Fluoroaniline due to the presence of the fluorine substituent.
Another related compound is 4-Fluoroaniline, which features a fluorine atom in the meta position to the amino group. Like 3-Fluoroaniline, 4-Fluoroaniline is a derivative of aniline with a fluorine atom attached to the benzene ring. Both compounds share similar reactivity and potential applications in various chemical reactions.
Additionally, N-Methylaniline is a compound that bears resemblance to 3-Fluoroaniline due to the presence of an amino group attached to the benzene ring. However, N-Methylaniline contains a methyl group attached to the amino group instead of a fluorine atom. Despite this difference, both compounds share similarities in their chemical properties and potential uses in organic synthesis.
